Search results for " DOC"
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La Méthode como hermenéutica musical Homenaje a Edgar Morin por su 100º cumpleaños
2021
The present work addresses the principles and properties of the complex thought formulated by the French thinker Edgar Morin and the way in which he was able me to articulate his conception of organizational complexity with one of the most important theories of musical analysis, which emerged at the beginning of the 20th century: the schenkerian analysis. It is a review and extension of a few pages of my doctoral thesis, which are intended to pay tribute to who has been, in addition to my teacher, Honorary President of Itamar since its first issue. His teachings and support has always been the engine for my quest for musical organization. On July 21, 2021, Morin celebrated his 100th birthda…
Elemental geochemistry of soils from the volcanic island of Pantelleria, Sicily: implications for Moscato wine production.
2006
The volcanic island of Pantelleria produces a naturally sweet wine Moscato di Pantelleria DOC obtained from the «Moscato d'Alessandria» (or «Zibibbo»), a grape favoured by hot climate. Geochemical and mineralogical investigations performed on soil profiles devoloped on rocks representative of the major outcropping lithologies (pantellerite, trachyte and alkalic basalt) show that the soils have preserved the parent material imprint. Consistently, values of the chemical index of alteration (CIA) indicate a low to moderate weathering degree for the rocks exposed in the Pantelleria area and consequently a low to moderate soil evolution. Soil-solution chemical analyses highlight that macro- and …
Lipid profiling following intake of the Omega 3 fatty acid DHA identifies the peroxidized metabolites F-4-Neuroprostanes as the best predictors of at…
2014
International audience; The anti-atherogenic effects of omega 3 fatty acids, namely eicosapentaenoic (EPA) and docosahexaenoic acids (DHA) are well recognized but the impact of dietary intake on bioactive lipid mediat or profiles remains unclear. Such a profiling effort may offer novel targets for future studies into the mechanism of action of omega 3 fatty acids. The present study aimed to determine the impact of DHA supplementation on the profiles of polyunsaturated fatty acids (PUFA) oxygenated metabolites and to investigate their contribution to therosclerosis prevention. A special emphasis was given to the non-enzymatic metabolites knowing the high susceptibility of DHA to free radical…
New potent antibacterials against Gram-positive multiresistant pathogens: effects of side chain modification and chirality in linezolid-like 1,2,4-ox…
2014
The effects of side chain modification and chirality in linezolid-like 1,2,4-oxadiazoles have been studied to design new potent antibacterials against Gram-positive multidrug-resistant pathogens. The adopted strategy involved a molecular modelling approach, the synthesis and biological evaluation of new designed compounds, enantiomers separation and absolute configuration assignment. Experimental determination of the antibacterial activity of the designed (S)-1-((3-(4-(3-methyl-1,2,4-oxadiazol-5- yl)phenyl)-oxazolidin-2-one-5-yl)methyl)-3-methylthiourea and (S)-1-((3-(3-fluoro-4-(3-methyl-1,2,4- oxadiazol-5-yl)phenyl)-oxazolidin-2-one-5-yl)methyl)-3-methylthiourea against multidrug resistan…
LifeRescue Software Prototype for Supporting Emergency Responders During Fire Emergency Response: A Usability and User Requirements Evaluation
2017
For an efficient emergency response, emergency responders (ERs) should exchange information with one another to obtain an adequate understanding and common operational picture of the emergency situation. Despite the current developments on information systems, many ERs are unable to get access to the relevant information as the data is heterogeneous and distributed at different places and due to security and privacy barriers. As a result, ERs are unable to coordinate well and to make good decisions. Therefore, to overcome these difficulties, a web-based application called LifeRescue was developed for supporting easy information access during emergency search and rescue operation. The goal o…
The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B
2021
Meprin β (Mβ) is a multidomain type-I membrane metallopeptidase that sheds membrane-anchored substrates, releasing their soluble forms. Fetuin-B (FB) is its only known endogenous protein inhibitor. Herein, we analyzed the interaction between the ectodomain of Mβ (MβΔC) and FB, which stabilizes the enzyme and inhibits it with subnanomolar affinity. The MβΔC:FB crystal structure reveals a ∼250-kDa, ∼160-Å polyglycosylated heterotetrameric particle with a remarkable glycan structure. Two FB moieties insert like wedges through a “CPDCP trunk” and two hairpins into the respective peptidase catalytic domains, blocking the catalytic zinc ions through an “aspartate switch” mechanism. Uniquely, the …
Data Banks and Multivariate Statistics in Physical Anthropology
1984
In recent decades, the fields of administration and economy, the press and - last but not least - the sciences have been characterized by an “explosion of knowledge”, and, as a consequence, by the problem of managing the rapidly increasing mass of information. It has been estimated that knowledge doubles each five years, and even that the interval of doubling seems to decrease. The main response to this challenge are computerized and structured data collections called data banks. “Data banks are systems of data collections which are organized according to logical and/or formal criteria; they should make it possible to reproduce the data of the total collection arranged according to differen…
Los museos etnológicos como instrumentos de formación ciudadana para hacer frente a los problemas que la humanidad tiene planteados
2017
Desde hace algunas décadas se viene llamando la atención desde diferentes ámbitos acerca de la insostenible situación de auténtica emergencia socioambiental planetaria en la que estamos inmersos y de la necesidad de contribuir a la formación de una ciudadanía consciente de dicha situación y preparada para participar en la toma de decisiones fundamentadas para hacer frente a la misma. Esta investigación responde a los llamamientos por Naciones Unidas a los educadores de todos los niveles, áreas y contextos, tanto de la educación formal como de la no reglada, con ese propósito de convertir la educación para la Sostenibilidad en una componente fundamental de la formación ciudadana. El objeto d…
ON NEW ROLES IN DIGITAL ENVIRONMENTS: E-DOCTORS AND E-PATIENTS
2014
Medical communication can be both a dialogue between expert-to-expert or expert-to-laymen (Cordella, 2004; Bowles, 2006; Candlin, 2006; Maynard and Hudak 2008; Lutfey and Maynard 1998; Heritage 2010; Heritage and Clayman, 2010 among others). In this last exchange, the doctor treats the patient as an ‘understanding recipient of medical reasoning’ (Peräkylä 1997) and language is simplified for communicative reasons (Koch-Weser et al., 2009). Patients are assumed as having little medical knowledge, which affects their understanding of medical terms and eventually leads to poor communication and to patients’ dissatisfaction (Candlin, Bruton and Leather, 1974; Coulthard and Ashby, 1975; Todd and…
De independencias, guerras, pueblos e Hispanidad : ecos del NO-DO
2012
El tratamiento que NO-DO da de estos dos acontecimientos -la Guerra de la Independencia y las independencias de las colonias latinoamericanas- es desigual, travestido e interesado. Ambos se envuelven en una retórica ritualista y ceremonial que sella las fechas a todo aire histórico y las entrega a la monótona repetición de una liturgia. Sin embargo, mientras la primera, a pesar de su inscripción en una retórica nacionalista, heroica y eterna, resulta incómoda al noticiario, probablemente por su asociación con el liberalismo, la modernidad y la escisión de España, la segunda es tan recurrente como mistificada. Las antiguas colonias del Nuevo Mundo serán tratadas desde el estrecho prisma de l…