Search results for " DOM"
showing 10 items of 2750 documents
The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development
2014
Summary CD8αα + intraepithelial lymphocytes (IELs) are instrumental in maintaining the epithelial barrier in the intestine. Similar to natural killer cells and other innate lymphoid cells, CD8αα + IELs constitutively express the T-box transcription factor T-bet. However, the precise role of T-bet for the differentiation or function of IELs is unknown. Here we show that mice genetically deficient for T-bet lacked both TCRαβ + and TCRγδ + CD8αα + IELs and thus are more susceptible to chemically induced colitis. Although T-bet was induced in thymic IEL precursors (IELPs) as a result of agonist selection and interleukin-15 (IL-15) receptor signaling, it was dispensable for the generation of IEL…
Low-dose dopamine agonist administration blocks vascular endothelial growth factor (VEGF)-mediated vascular hyperpermeability without altering VEGF r…
2006
No specific treatment is available for ovarian hyperstimulation syndrome (OHSS), the most important complication in infertile women treated with gonadotropins. OHSS is caused by increased vascular permeability (VP) through ovarian hypersecretion of vascular endothelial growth factor (VEGF)activating VEGF receptor 2 (VEGFR-2). We previously demonstrated in an OHSS rodent model that increased VP was prevented by inactivating VEGFR-2 with a receptor antagonist(SU5416).However,duetoitstoxicity(thromboembolism) and disruption of VEGFR-2-dependent angiogenic processes critical for pregnancy, this kind of compound cannot be used clinically to prevent OHSS. Dopamine receptor 2 (Dp-r2) agonists, use…
Shared midgut binding sites for Cry1A.105, Cry1Aa, Cry1Ab, Cry1Ac and Cry1Fa proteins from Bacillus thuringiensis in two important corn pests, Ostrin…
2013
First generation of insect-protected transgenic corn (Bt-corn) was based on the expression of Cry1Ab or Cry1Fa proteins. Currently, the trend is the combination of two or more genes expressing proteins that bind to different targets. In addition to broadening the spectrum of action, this strategy helps to delay the evolution of resistance in exposed insect populations. One of such examples is the combination of Cry1A.105 with Cry1Fa and Cry2Ab to control O. nubilalis and S. frugiperda. Cry1A.105 is a chimeric protein with domains I and II and the C-terminal half of the protein from Cry1Ac, and domain III almost identical to Cry1Fa. The aim of the present study was to determine whether the c…
Reconstructing Bronze Age diets and farming strategies at the early Bronze Age sites of La Bastida and Gatas (southeast Iberia) using stable isotope …
2020
The El Argar society of the Bronze Age in the southeast of the Iberian Peninsula (2200–1550 cal BCE) was among the first complex societies in Europe. Its economy was based on cereal cultivation and metallurgy, it was organized hierarchically, and successively expanded its territory. Most of the monumentally fortified settlements lay on steeply sloped mountains, separated by fertile plains, and allowed optimal control of the area. Here, we explore El Argar human diets, animal husbandry strategies, and food webs using stable carbon and nitrogen isotope analysis of charred cereal grains as well as human and animal bone collagen. The sample comprised 75 human individuals from the sites of La Ba…
Per una lettura socio-economica dei contesti abitativi: L’insula I del Quartiere ellenistico-romano di Agrigento. La domus I A – I B
2021
In linea con le ultime ricerche organizzate dal Parco Archeologico Regionale Valle dei Templi di Agrigento, il cui scopo è la conoscenza dell'antica città di Akragas/Agrigentum come sistema integrato e unitario, si è dedicata nuova attenzione alle forme dell'abitare, in particolare nell'area del cosiddetto "Quartiere ellenistico-romano". Quest'area fu scavata negli anni '50 e '60 del secolo scorso, ma è con la pubblicazione di E. De Miro, avvenuta solo nel 2009, che è stato possibile conoscere i risultati delle indagini. In questo contributo ci si vuole concentrare sull'isolato I del Quartiere, contraddistinto da due grandi abitazioni (I A/B e I E/F) che dominano l'area pubblica dell'agorà.…
La Casa II A o Casa del mosaico a rombi
2019
Una breve descrizione della Casa II A del quartiere ellenistico-romano di Agrigento A short description of the House II A of the Hellenistic-Roman Quartier in Agrigento
Unlocking Plum Genetic Potential: Where Are We At?
2022
Plums are a large group of closely related stone fruit species and hybrids of worldwide economic importance and diffusion. This review deals with the main aspects concerning plum agrobiodiversity and its relationship with current and potential contributions offered by breeding in enhancing plum varieties. The most recent breeding achievements are revised according to updated information proceeding from relevant scientific reports and official inventories of plum genetic resources. A special emphasis has been given to the potential sources of genetic traits of interest for breeding programs as well as to the need for efficient and coordinated efforts aimed at efficaciously preserving the ric…
Omnibus literatis et cum primis Gymnasii nostri civibus
1641
Rīgas Domskolas konrektora Kristofs Šallera dzejā sarakstītais Encomium Rigae totius Livoniae metropoleos celeberrimae: Slavinājums Rīgai visas Livonijas metropolei (1640). Izdevumā arī pilsētas skolu inspektora un Rīgas mācītāja H. samsona "Omnibus literatis et cum primis Gymnasii nostri civibus" un K. Šallera "Oratio auguralis de iuvenilis institutionis praestantia"
An Epidemiological Study to Investigate Links between Atmospheric Pollution from Farming and SARS-CoV-2 Mortality.
2022
Exposure to atmospheric particulate matter and nitrogen dioxide has been linked to SARS-CoV-2 infection and death. We hypothesized that long-term exposure to farming-related air pollutants might predispose to an increased risk of COVID-19-related death. To test this hypothesis, we performed an ecological study of five Italian Regions (Piedmont, Lombardy, Veneto, Emilia-Romagna and Sicily), linking all-cause mortality by province (administrative entities within regions) to data on atmospheric concentrations of particulate matter (PM2.5 and PM10) and ammonia (NH3), which are mainly produced by agricultural activities. The study outcome was change in all-cause mortality during March–Apri…
Explicit Kutta Condition for Unsteady Two-Dimensional High-Order Potential Boundary Element Method
1997
An explicit unsteady pressure Kutta condition is discribed that was directly and efficiently implemented in a time domain high-order potential panel method so as to ensure the pressure equality on the upper and lower surfaces at the trailing edge of the airfoil at each time step.