Search results for " DOM"
showing 10 items of 2750 documents
Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs
2021
Class I SH3 domain-binding motifs generally comply with the consensus sequence [R/K]x0PxxP, the hydrophobic residue 0 being proline or leucine. We have studied the unusual 0 = Ala-specificity of SNX9 SH3 by determining its complex structure with a peptide present in eastern equine encephalitis virus (EEEV) nsP3. The structure revealed the length and composition of the n-Src loop as important factors determining specificity. We also compared the affinities of EEEV nsP3 peptide, its mutants, and cellular ligands to SNX9 SH3. These data suggest that nsP3 has evolved to minimize reduction of conformational entropy upon binding, hence acquiring stronger affinity, enabling takeover of SNX9. The R…
Limit on the production of a light vector gauge boson in $\phi $ mesondecays with the KLOE detector
2012
We present a new limit on the production of a light dark-force mediator with the KLOE detector at DAPHNE. This boson, called U, has been searched for in the decay phi --> eta U, U --> e+ e-, analyzing the decay eta --> pi0 pi0 pi0 in a data sample of 1.7 fb-1. No structures are observed in the e+e- invariant mass distribution over the background. This search is combined with a previous result obtained from the decay eta --> pi+ pi- pi0, increasing the sensitivity. We set an upper limit at 90% C.L. on the ratio between the U boson coupling constant and the fine structure constant of alpha'/alpha < 1.7x10^-5 for 30<M_U<400 MeV and alpha'/alpha < 8x10^-6 for the sub-region 50<M_U<210 MeV. This…
Medical Data Processing and Analysis for Remote Health and Activities Monitoring
2019
Recent developments in sensor technology, wearable computing, Internet of Things (IoT), and wireless communication have given rise to research in ubiquitous healthcare and remote monitoring of human’s health and activities. Health monitoring systems involve processing and analysis of data retrieved from smartphones, smart watches, smart bracelets, as well as various sensors and wearable devices. Such systems enable continuous monitoring of patients psychological and health conditions by sensing and transmitting measurements such as heart rate, electrocardiogram, body temperature, respiratory rate, chest sounds, or blood pressure. Pervasive healthcare, as a relevant application domain in thi…
Detection, characterization and sizing of hydrogen induced cracking in pressure vessels using phased array ultrasonic data processing
2016
Abstract Pressure vessels operating in sour service conditions in refinery environments can be subject to the risk of H₂S cracking resulting from the hydrogen entering into the material. This risk, which is related to the specific working conditions and to the quality of the steel used, shall be properly managed in order to maintain the highest safety at a cost-effective level. Nowadays the typical management strategy is based on a risk based inspection (RBI) evaluation to define the inspection plan used in conjunction with a fitness for service (FFS) approach in defining if the vessel, although presenting dangerous defects such as cracks, can still be considered “fit for purpose” for a giv…
A Little Bird Told Me: Discovering KPIs from Twitter Data
2020
The goal of our research and experiments is to find the definitions and values of key performance indicators (KPIs) in unstructured text. The direct access to opinions of customers served as a motivating factor for us to choose Twitter data for our experiments. For our case study, we have chosen the restaurant business domain. As in the other business domains, KPIs often serve as a solution for identification of current problems. Therefore, it is essential to learn which criteria are important to restaurant guests. The mission of our Proof-of-Concept KPI discovery tool presented in this paper is to facilitate the explorative analysis taking Twitter user posts as a data source. After process…
Effectively and efficiently supporting crowd-enabled databases via NoSQL paradigms
2013
In this paper we provide an overview of the Hints From the Crowd (HFC) project, whose main goal is to build a NoSQL database system for large collections of product reviews; the database is queried by expressing a natural language sentence; the result is a list of products ranked based on the relevance of reviews w.r.t. the natural language sentence. The best ranked products in the result list can be seen as the best hints for the user based on crowd opinions (the reviews). The HFC prototype has been developed as a web application, independent of the particular application domain of the collected product reviews. Queries are performed by evaluating a text-based ranking metric for sets of re…
Comprehensive System for Systematic Case-Driven Software Reuse
2010
Reuse of software artifacts (blueprints and code) is normally associated with organising a systematic reuse framework most often constructed for a specific problem domain. In this paper we present a system (language, tool, reuse process) where software reuse is based on building and retrieving of so-called software cases (large compound artifacts) that can be reused between domains. The system is opportunistic in that software cases result from usual (non-reuse oriented) activities where also semantic information is added. This information is used to support regular development but may serve later to retrieve software cases. Having this common semantic basis, we can organise a systematic cr…
Mājas daudzfunkcionālais serveris
2015
21.gadsimta mājās nekāds retums vairs nav viens vai divi datori. Katram ģimenes loceklim ir savs, vai pat divi datori, kas kalpo ikdienas darbu veikšanai, taču to savstarpējā komunicēšana un uzturēšana nevienmēr ir tas vieglākais darbs un var radīt pavisam lielas galvas sāpes mājas iedzīvotājiem, problēmu gadījumā. Pateicoties iespējai izveidot mājas serveri, ir iespējams nodrošināt vienu kopēju vietu iemītnieku datņu glabāšanai, kas paredz iespēju koplietot izvēlētos datus starp tiem savstarpēji, kā arī izveidot automatizācijas procesu datoru uzstādīšanai, lai pēc iespējas vairāk samazinātu patērēto laiku, sistēmu konfigurēšanai un uzturēšanai. Darba gaitā tiek izveidots multifunkcionāls m…
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL…
2009
Abstract This paper shows that the histone deacetylase inhibitor SAHA sensitised at sub-toxic doses human hepatocellular carcinoma cells (HepG2, Hep3B and SK-Hep1) to TRAIL-induced apoptosis, while it was ineffective in primary human hepatocytes (PHHs). In particular in HCC cells SAHA increased the expression of death receptor 5 (DR5) and caused a decrement of c-Flip. These two modifications provoked in the presence of TRAIL the rapid production of TRAIL-DISC and the activation of caspase-8. Consequently SAHA/TRAIL combination induced many apoptotic events, such as a cleavage of Bid into tBid, dissipation of mitochondrial membrane potential, activation of caspase-3 with the consequent cleav…
CD95 death-inducing signaling complex formation and internalization occur in lipid rafts of type I and type II cells
2004
We investigated the membrane localization of CD95 in type I and type II cells, which differ in their ability to recruit and activate caspase-8. We found that CD95 was preferentially located in lipid rafts of type I cells, while it was present both in raft and non-raft plasma membrane sub-domains of type II cells. After stimulation, CD95 located in phospholipid-rich plasma membrane was recruited to lipid rafts in both types of cells. Similarly, CD95 cross-linking resulted in caspase-independent translocation of FADD/MORT1 and caspase-8 to the lipid rafts, which was prevented by a death domain-defective receptor. CD95 internalization was then rapid in type I and delayed in type II cells and s…