Search results for " DOP"
showing 10 items of 770 documents
Synthesis and Dopamine Receptor Selectivity of the Benzyltetrahydroisoquinoline, (R)-(+)-nor-Roefractine
1998
(R)-(+)-nor-Roefractine (1) was synthesized by the Bischler-Napieralski route, using asymmetric reduction of the 1, 2-didehydro precursor imine with sodium (S)-N-CBZ-prolinyloxyborohydride. Compound 1 was able to displace [3H]-raclopride (a D2 dopamine receptor-selective ligand) from its specific binding sites in rat striatum with selectivity vs [3H]-SCH23390 (D1 dopamine receptor-selective ligand).
US-Elastography for Breast Lesion Characterization: Prospective Comparison of US BIRADS, Strain Elastography and Shear wave Elastography
2020
To evaluate the diagnostic performance of strain elastography (SE) and 2 D shear wave elastography (SWE) and SE/SWE combination in comparison with conventional multiparametric ultrasound (US) with respect to improving BI-RADS classification results and differentiating benign and malignant breast lesions using a qualitative and quantitative assessment. In this prospective study, 130 histologically proven breast masses were evaluated with baseline US, color Doppler ultrasound (CDUS), SE and SWE (Toshiba Aplio 500 with a 7-15 MHz wide-band linear transducer). Each lesion was classified according to the BIRADS lexicon by evaluating the size, the B-mode and color Doppler features, the SE qualit…
Das kompositorische Verfahren in Jean Moutons Quadrupelkanon Nesciens mater virgo virum
2012
Anhand der kompositorischen Probleme, die sich bei der Konzeption mehr als zweistimmiger Kanons ergeben, wird der Frage nachgegangen, wie der konkrete Kompositionsprozess um 1500 ausgesehen haben konnte. Eine Analyse von Jean Moutons Motette Nesciens mater zeigt, dass die Wechselwirkungen zwischen Kanonkonzeption, Klangfolge und melodischer Gestaltung eine simultane Kompositionsweise voraussetzen, in der die Klangfolge wechselnde Verhaltnisbestimmungen als Resultat und Voraussetzung der kontrapunktischen Konfiguration erfahrt: Der Wechsel von der Sukzessiv- zur Simultankonzeption erscheint in Bezug auf komplexe Kanonbildungen als ein verfahrenstechnisches Erfordernis.
30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed into the Developmental Risk Factor Model of Psychosis
2017
At its re-birth 30 years ago, the neurodevelopment hypothesis of schizophrenia focussed on aberrant genes and early neural hazards, but then it grew to include ideas concerning aberrant synaptic pruning in adolescence. The hypothesis had its own stormy development and it endured some difficult teenage years when a resurgence of interest in neurodegeneration threatened its survival. In early adult life, it over-reached itself with some reductionists claiming that schizophrenia was simply a neurodevelopmental disease. However, by age 30, the hypothesis has matured sufficiently to incorporated childhood and adult adversity, urban living and migration, as well as heavy cannabis use, as importan…
Stimulant-induced adaptations in neostriatal matrix and striosome systems: Transiting from instrumental responding to habitual behavior in drug addic…
2005
Abstract Converging evidence indicates that repeated exposure to motor stimulants such as cocaine and amphetamine produces marked alterations in network responsiveness of striatal neurons to subsequent challenge with the same stimulant drug. Such alterations, which correlate with persistent patterns of repetitive behavior, associate with distinct compartmental changes in the neostriatum. Striatal matrix system neurons undergo “silencing” following repeated drug challenges, allowing striosome system neurons to exhibit preferential activation. Matrix neurons are innervated by sensory and motor areas of neocortex and are activated in the course of on-going, adaptive behavior. Inactivation of m…
Use of middle cerebral velocity and blood pressure for the analysis of cerebral autoregulation at various frequencies: The coherence index
1998
A common component in many protocols for the evaluation of cerebral autoregulation is the comparison of transcranial Doppler ultrasound (TCD) velocities with blood pressure recordings, in which correlations between these two signals correspond to impaired autoregulation. With long data sets and complicated paradigms, however, visual inspection alone cannot adequately distinguish random coincidence from consistent correlation in a statistically valid fashion. We suggest and illustrate the use of the coherence index for this purpose. To illustrate this technique, long-term recordings of TCD velocity and blood pressure were obtained from 6 normal subjects and using 23 data segments from 8 pati…
The effect of Fe doping on superconductivity in ZrRuP
2011
Abstract This work reports the structure and superconducting properties of the superconductor ZrRuP doped with Fe; the ZrRu 1− x Fe x P solid solution was investigated by means of X-ray powder diffraction, SQUID magnetometry and Mosbauer spectroscopy. It is shown that the modification of the superconducting properties by doping with Fe is similar to the effect of chemical pressure and that the Fe doped compounds do not show any magnetic ordering.
Magnetic ordering in Fe-doped Gd2 BaCuO5
1994
The structural and magnetic properties of iron-doped Gd2BaCuO5 have been studied by X-ray diffractometry, Mossbauer spectroscopy and susceptibility measurements. Mossbauer data on Gd2BaCu0.8Fe0.2O5 show that at room temperature Fe is not magnetically ordered, displaying hyperfine parameters similar to those generally assigned to Fe at Cu(2) sites in the GdBa2(Cu1−x; Fe; x; )3O7 superconductor. Susceptibility measurements demonstrate that Gd2BaCu1−x; Fe; x; O5 behaves like a three-dimensional antiferromagnet withT; N=11.9±0.1 K, independent ofx. The effective magnetic moment calculated within a mean field approximation is consistent with an ordering of the Gd sublattice.
A Comprehensive Ultrasonographic Assessment of Pediatric and Adolescent Varicocele Can Improve Surgical Results.
2020
<b><i>Purpose:</i></b> Undetected refluxing venous systems could cause persistence/recurrence of varicoceles in patients undergoing varicocelectomy. Color Doppler ultrasound (CDUS) is an important tool in the diagnosis and follow-up of varicocele, and could be successfully used to detect a venous reflux in the iliac-deferential district, usually involved in the recurrence/persistence of varicocele. <b><i>Materials and Methods:</i></b> We compared 2 historical series of patients treated with Palomo laparoscopic varicocelectomy between 1994 and 2018. In group 1, preoperative scrotal CDUS was obtained, while in group 2, additional inguinal CDUS w…