Search results for " Damage"
showing 10 items of 1139 documents
Brevi note su alcune esperienze di trapianti giuridici in Europa
2016
The research aims to explain and illustrate the legal transplants theory, created by the well-known Scottish jurist Alan Watson, and tries to discover the foundation of its legitimacy in relation with some common law rules. In fact some relevant private law rules, which have been transplanted in more legal systems, will be examined so to underline the different impact of the same rule in different contexts for the deep influence of social, cultural and political factors on the legal principles. Specifically the different impact on legal systems of a particular civil action, the class action, born in Usa and circulated both in civil and in common law countries, will be examined. In the same …
INTEGRATED SYSTEMS IN PLANT PROTECTION MANAGEMENT: FIRE BLIGHT OF ROSACEOUS PLANTS (Erwinia amylovora (Burrill) - Winslow) IN AN APPLE ORCHARD IN SIB…
2013
Integrated protection represents a modern approach, denoting a protection strategy of agro-ecosystems; and it represents a complex system employing all appropriate methods in a manner as consistent and smooth as possible, in order to maintain the biocenotic balance of agrosystems and to keep pathogens at a level at which they do not cause economic damage (so-called level of eco-efficiency). A biocenotic approach to issues of agrosystem protection against disease attack requires an acknowledgement of all aspects regarding the evolution of pests in time and space, so as to be able to intervene at the right time with all possible means. And such protection measures are not supposed to restrain…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.
2012
To investigate the potency of the topoisomerase II (topo II) poisons doxorubicin and etoposide to stimulate the DNA damage response (DDR), S139 phosphorylation of histone H2AX (γH2AX) was analyzed using rat cardiomyoblast cells (H9c2). Etoposide caused a dose-dependent increase in the γH2AX level as shown by Western blotting. By contrast, the doxorubicin response was bell-shaped with high doses failing to increase H2AX phosphorylation. Identical results were obtained by immunohistochemical analysis of γH2AX focus formation, comet assay-based DNA strand break analysis, and measuring the formation of the topo II-DNA cleavable complex. At low dose, doxorubicin activated ataxia telangiectasia m…
Achilles tendon viscoelastic properties and mechanical responses to a single bout of exercise
2014
Intérêts et limites de l’electrostimulation pour l’évaluation, le traitement et la prévention des altérations neuromusculaires induites par l’exercic…
2004
L'objectif de ce travail était d'une part d'étudier les altérations neuromusculaires induites par un exercice excentrique sollicitant les muscles extenseurs du genou, et d'autre part d'étudier l'efficacité de l'électrostimulation (ES) comme moyen d'évaluation, de traitement et de prévention de ces altérations. La première étude de ce travail consistait à évaluer les contributions des mécanismes centraux et périphériques à la diminution de la contraction maximale volontaire observée après l'exercice excentrique. La fatigue basse fréquence (FBF) et la fatigue centrale expliquaient principalement la diminution du moment maximal volontaire après l'exercice excentrique. Le but de la deuxième étu…
Acute and chronic effects of cold treatment on physiological variables and neuromuscular function during a short training period in men
2015
Introduction. Recovery following various physical exercises is a complicated process. The exercise session can involve strong demands on both muscle structure and energy production (aerobic and anaerobic). Many exercise sessions also induce muscle damage (exercise induced muscle damage; EIMD). Different recovery methods attempt to alleviate or prevent EIMD and its associated symptoms, such as muscle soreness and swelling, and reduction in muscle function. One of the used strategies is cold treatment (cryotherapy), which decreases tissue temperature and subsequently effects on e.g. blood flow, metabolism and neural conductance velocity. To date, there is conflicting evidence to support the u…
Monitoraggio e valutazione del danno degli insetti defogliatori su diverse specie di Quercus in Sicilia
Most of the insects feeding on oaks are usually ‘in balance’ with their host trees, causing occasional damage. When severe defoliations regularly occur, oak trees vulnerability to the complex of factors causing the overall decline syndrome can increase. Assessing canopy damage due to defoliating insects through the usually adopted visual methods is quite difficult, requiring highly experienced operators and a long time spent to collect field data. The present research has been carried out to investigate the different susceptibility of Sicilian oak species to defoliating insect attacks, in particular the oak moth Tortrix viridana (L.) (Lepidoptera Tortricidae), with the aim to assess the rel…
Osservazioni intorno a Sopravvenienze e rimedi nei contratti di durata
2019
The essay deals with the subject of contractual change of circumstances and related remedies. In particular, the work focuses on the debate on the possibility of configuring a legal renegotiation obligation in the Italian legal system. The critical examination of favorable positions allows us to offer a more precise reading on the margins of application of the renegotiation.
Odpowiedzialność Skarbu Państwa wobec akcjonariuszy (udziałowców) upadłego za szkodę wyrządzoną przez Sąd Upadłościowy poprzez niesłuszne orzeczenie …
2021
Niniejsze opracowanie odnosi się do zagadnień związanych z odpowiedzialnością odszkodowawczą Skarbu Państwa w stosunku do udziałowców dłużnika z tytułu błędnego orzeczenia o opcji upadłości likwidacyjnej zamiast o opcji restrukturyzacji. Postępowanie wszczyna się na wniosek uprawnionego. O otwarciu postępowania decyduje sąd. W praktyce może dojść do sytuacji, w której będą złożone konkurencyjne względem siebie wnioski: albo zmierzające do likwidacji majątku dłużnika, albo mające na celu jego restrukturyzację. Opracowanie odnosi się do dwóch stanów prawnych: do stanu prawnego obowiązującego w latach 2003–2015 i do stanu prawnego zującego od 2016 r. W artykule poddano analizie ustawowe kryter…