Search results for " Damage"
showing 10 items of 1139 documents
Late Activation of Stress-activated Protein Kinases/c-Jun N-terminal Kinases Triggered by Cisplatin-induced DNA Damage in Repair-defective Cells
2011
Although stress-activated protein kinases/c-Jun N-terminal kinases (SAPK/JNK) are rapidly activated by genotoxins, the role of DNA damage in this response is not well defined. Here we show that the SEK1/MKK4-mediated dual phosphorylation of SAPK/JNK (Thr-183/Tyr-185) correlates with the level of cisplatin-DNA adducts at late times (16–24 h) after drug treatment in both human and mouse cells. Transfection of platinated plasmid DNA also caused SAPK/JNK activation. A defect in transcription-coupled nucleotide excision repair resting on a mutation in Cockayne syndrome group B protein promoted the late SAPK/JNK activation following cisplatin exposure. Signaling to SAPK/JNK was accompanied by act…
Lesiones de hemisferio derecho. Materiales y análisis pragmático (Volumen VII del corpus PerLA).
2011
El corpus PerLA (“Percepción, Afasia y Lenguaje”), surge en el área de Lingüística General de la Universitat de València como respuesta a la necesidad de integrar el estudio de las patologías lingüísticas en las tendencias actuales de la pragmática y la lingüística de corpus. En esta ocasión se presentan seis transcripciones en las que participa un hablante con lesión cerebral de hemisferio derecho, una situación que ha sido poco investigada desde planteamientos lingüístico-logopédicos, y para la que la bibliografía suele proponer síntomas de escaso alcance verbal, como la disprosodia o la agnosia visual. No obstante, el análisis detenido de los datos ecológicos permite comprobar la alterac…
La resistibile ascesa del risarcimento punitivo nell’ordinamento italiano (a proposito dell’ordinanza n. 9978/2016 della Corte di Cassazione)
2017
Blood Flow Restriction Exercise: Considerations of Methodology, Application, and Safety
2020
Invasive Northern red oaks benefit temnothorax crassispinus (Hymenoptera: Formicidae) ant colonies
2018
Non-native plant species can modify their environment, and their influence on food chains is well recognized. How ever, the phenomenon of non-nutrient dependent interaction between non-native plants and native animals has received little attention to date. The Northern Red Oak (Quercus rubra) is a non-native, invasive tree species in Europe, which strongly negatively influences co-occurring plants. However, a part of the native fauna is able to utilize the resources offered by this species in its non-native range. We studied a common species of wood ant, Temnothorax crassispinus, in forests under canopies of non-native Northern Red Oak and native oaks, Pedunculate Oak (Q. robur), and Sessil…
Bcl-xL as a Modulator of Senescence and Aging
2021
Many features of aging result from the incapacity of cells to adapt to stress conditions. When cells are overwhelmed by stress, they can undergo senescence to avoid unrestricted growth of damaged cells. Recent findings have proven that cellular senescence is more than that. A specific grade of senescence promotes embryo development, tissue remodeling and wound healing. However, constant stresses and a weakening immune system can lead to senescence chronicity with aging. The accumulation of senescent cells is directly related to tissue dysfunction and age-related pathologies. Centenarians, the most aged individuals, should accumulate senescent cells and suffer from their deleterious effects,…