Search results for " Damage"
showing 10 items of 1139 documents
Early ROS-mediated DNA damage and oxidative stress biomarkers in Monoclonal B Lymphocytosis
2012
Monoclonal B Lymphocytosis (MBL) is defined as asymptomatic monoclonal B-cell expansion characterised by a CLL-phenotype, but with less than 5 x 10(9)/I circulating cells. Reactive oxygen species (ROS)-mediated cell damage plays a critical role in the initiation of carcinogenesis as well as in malignant transformation. The goal of this study was to perform an analysis of the oxidative stress statuses of patients affected by MBL and chronic lymphocytic leukaemia (CLL). We examined peripheral blood and urine specimens from 29 patients with MBL, 55 with CLL and 31 healthy subjects. There was a significant increase in the occurrence of the mutagenic base 8-oxo-2'-deoxiguanosine (8-oxo-dG) in th…
Cíborgs : res ipsa loquitur
2020
En el presente trabajo analizamos el daño desproporcionado sobre la naturaleza humana causado por el fenómeno cíborg a través de su encaje en la regla res ipsa loquitur, o la cosa habla por sí sola. Por un lado, fundamentamos lo que denominados naturaleza humana haciendo referencia a las iguales capacidades humanas, necesarias en el cumplimiento de funciones vitales. Por otro, esta regla recibe también el nombre de daño desproporcionado y su teoría vincula el resultado causado sobre la cosa con la lex artis de una profesión, de ahí que, para su análisis jurídico, hayamos optado por el ámbito sanitario
La delimitación del concepto de daño moral: un estudio de la cuestión en el ordenamiento jurídico español.
2021
El presente estudio tiene como objetivo realizar una aproximación al concepto de daño moral en el derecho español porque, a diferencia del daño patrimonial, el Código Civil no proporciona un concepto sobre él. Para la articulación de un concepto de daño moral es necesario analizar los supuestos de reconocimiento legal, la interpretación que los órganos judiciales han hecho y el tratamiento proporcionado en los Principios de derecho contractual europeo y de derecho de daños europeo. El trabajo finaliza con una valoración sobre la actual configuración del daño moral. The present study aims to make an approximation to the concept of non-pecuniary damage in Spanish law because, unlike property …
Il danno da perdita del rapporto parentale nella giurisprudenza italiana
2018
Il presente lavoro si occupa di uno dei più controversi e complessi temi della responsabilità civile in Italia, ossia quello concernente la risarcibilità dei danni non patrimoniali sofferti per la perdita di un parente. Nonostante l?assenza di una specifica disposizione nel codice civile italiano, la Corte di Cassazione ha stabilito che questi danni possono essere liquidati, ma solo se sussistono condizioni ben precise, determinate dallo stesso Supremo Collegio
Irradiated silicon detectors for HL-LHC: Characterization and simulations
2012
283 páginas. Tesis Doctoral del Departamento de Física Atómica, Molecular y Nuclear, de la Universidad de Valencia. Fecha de lectura: 18 julio 2012.
Nuevos recursos sanitarios en época de crisis: el papel del trabajador social en la Unidad de Neurorehabilitación Infantil del Hospital de Manises
2013
En los últimos años se ha detectado un aumento en los niños diagnosticados con Trastornos Generalizados del Desarrollo (TGD) y Daño Cerebral (DC). Al mismo tiempo la formación e información por parte de los profesionales que intervienen con estos niños también es mayor por lo que el Departamento de Salud de Manises creó en mayo del 2012 la primera Unidad de Neurorrehabilitación Infantil integrada en un hospital público valenciano especializada en estos casos. La Unidad está atendida por un equipo de profesionales especializados en TGD y DC, tanto en el diagnóstico como en la intervención y con una filosofía de trabajo interdisciplinar. Este equipo cuenta con la figura del trabajador social …
Chemical Composition of Thymus leucotrichus var. creticus Essential Oil and Its Protective Effects on Both Damage and Oxidative Stress in Leptodictyu…
2022
The chemical profile of the essential oil (EO) of the aerial parts of Thymus leucotrichus var. creticus (Lamiaceae), a taxon not previously studied, was investigated by GC–MS analysis, using a DB–Wax polar column. Oxygenated monoterpenes and monoterpene hydrocarbons dominate the EO, with thymol (46.97%) and p-cymene (28.64%) as the main constituent of these two classes, respectively. The ability of the EO of T. leucotrichus to reduce Cd toxicity was studied in aquatic moss Leptodictyum riparium. To study EO-induced tolerance to Cd toxicity, apex growth, number of dead cells, DNA damage and antioxidant response in gametophytes were examined. The exogenous application of the EO yields a resum…
Abstract 857: Metal oxide nanoparticles as adjuvant for radiation therapy
2018
Abstract Background: Radiation therapy comprises a fundamental component of modern tumor treatment. Unfortunately, its success is limited by the development of radiation resistances. The emerging field of nanotechnology offers great opportunities for diagnosing, imaging, as well as treating cancer. Metal oxide nanoparticles in particular zinc oxide nanoparticles (ZnO-NP) have been shown to display a selective cytotoxic effect on tumor cells via a yet unknown mechanism. Most likely the generation of reactive oxygen species (ROS), breakdown of mitochondria and DNA damage are involved. The success of radiation therapy equally relies on the generation of ROS, which develop their cytotoxic poten…
Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells
2021
Abstract DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as G-quadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by small molecules (ligands) that have high chemotherapeutic potential, either as standalone DNA damaging agents or combined in synthetic lethality strategies. While previous approaches have claimed to use ligands that specifically target either G4s or TWJs, we report here on a new approach in which ligands targeting both TWJs and G4s in vitro demonstrate cellular effects distinct from that of G4 ligands, and attributable to TWJ targeting. The DNA binding modes of these new, dual TWJ-/G4-ligands w…
Food-grade argan oil supplementation in molasses enhances fermentative performance and antioxidant defenses of active dry wine yeast
2015
The tolerance of the yeast Saccharomyces cerevisiae to desiccation is important for the use of this microorganism in the wine industry, since active dry yeast (ADY) is routinely used as starter for must fermentations. Both biomass propagation and dehydration cause cellular oxidative stress, therefore negatively affecting yeast performance. Protective treatments against oxidative damage, such as natural antioxidants, may have important biotechnological implications. In this study we analysed the antioxidant capacity of pure chemical compounds (quercetin, ascorbic acid, caffeic acid, oleic acid, and glutathione) added to molasses during biomass propagation, and we determine several oxidative …