Search results for " Decline"

Persistence of both reversible airway obstruction and higher blood eosinophils may predict lung function decline in severe asthma.

2021

Objective: This study analysed whether the persistence of both reversible airway obstruction (RAO) and elevated BE counts was associated to reduced asthma control and accelerated lung function decline in treated severe asthmatics. Methods: About 202 severe asthmatics were studied after 12–120 months of step-5 treatment associated to anti-IgE therapy. Following treatments, reversibility tests, after inhaling 400 mcg of Salbutamol, were performed. FEV1 > 12% or ≤12% changes differentiated RAO+ from RAO− subjects. Blood eosinophil (BE) counts after treatment were considered. Results: Pre-/post-treatment bronchodilator FEV1% and ACT were lower (61% [50–71], 74.4% [62.5–83.7] and 20[18–22]), …

Influence of Severe Carotid Stenosis on Cognition, Depressive Symptoms and Quality of Life.

2017

Background: Carotid artery disease is not just a causal risk factor of ischemic stroke, but may predispose patients to depressive symptoms and low health related quality of life (HRQoL). Objectives: The objectives of the present study were to assess the association between severe carotid artery stenosis (CAS) and cognitive impairment, frequency of depressive symptoms and status of HRQoL. Methods: Cross - sectional study involved 55 patients with severe CAS and 54 patients with lower extremity peripheral artery disease (PAD). Cognitive impairment was assessed using Montreal Cognitive Assessment Scale (MoCA), depressive symptoms - PHQ-9 scale. HRQoL was measured using Medical Outcome Survey …

The natural history of Alzheimer disease: a longitudinal presymptomatic and symptomatic study of a familial cohort

2004

BACKGROUND: Knowledge of the evolution of cognitive deficits in Alzheimer disease is important for our understanding of disease progression. Previous reports, however, have either lacked detail or have not covered the presymptomatic stages. OBJECTIVE: To delineate the onset and progression of clinical and neuropsychological abnormalities in familial Alzheimer disease. METHODS: Nineteen subjects with familial Alzheimer disease underwent serial clinical and neuropsychological assessments. Eight of these had undergone presymptomatic assessments. The follow-up period was 1 to 10 years (mean, 5 years). The relative timing of the occurrence of 3 markers of disease onset and progression (onset of …

Relationship between low Ankle-Brachial Index and rapid renal function decline in patients with atrial fibrillation: a prospective multicentre cohort…

2015

Objective: To investigate the relationship between Ankle-Brachial Index (ABI) and renal function progression in patients with atrial fibrillation (AF). Design: Observational prospective multicentre cohort study. Setting: Atherothrombosis Center of I Clinica Medica of 'Sapienza' University of Rome; Department of Medical and Surgical Sciences of University Magna Græcia of Catanzaro; Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study. Participants: 897 AF patients on treatment with vitamin K antagonists. Main outcome measures: The relationship between basal ABI and renal function progression, assessed by the estimated Glomerular Filtration R…

Chaperonopathies of senescence and the scrambling of interactions between the chaperoning and the immune systems

2010

Aging entails progressive deterioration of molecules and supramolecular structures, including Hsp chaperones and their complexes, paralleled by functional decline. Recent research has changed our views on Hsp chaperones. They work inside and outside cells in many locations, alone or forming teams, interacting with cells, receptors, and molecules that are not chaperones, in roles that are not typically attributed to chaperones, such as protein folding. Hsp chaperones form a physiological system with a variety of functions and interactions with other systems, for example, the immune system. We propose that chaperone malfunctioning due to structural damage or gene dysregulation during aging ha…

Dietary prevention of visual function and cognitive decline by omega-3 polyunsaturated fatty acids in Senescence Accelerated Mouse P8 (SAM P8)

2008

International audience; Purpose: : Neuronal tissues such as the brain and the retina contain elevated amounts of long-chain omega-3 polyunsaturated fatty acids (PUFAs) and particularly docosahexaenoic acid (DHA). DHA concentrations are known to decrease in the aging brain and are associated with cognitive decline. The senescence-accelerated mouse prone 8 (SAM P8) is a mouse model for aging that exhibits deficits in cognitive performances as well as alterations of retinal functionality (ARVO 2004 E-abstract 797). The aim of this study was to evaluate the effects of a dietary supplementation with DHA on mood, cognition and visual functionality of SAM P8 during aging. Methods: : SAM P8 mice we…

Climatic signals of tree-ring in Quercus gussonei (Borzì) Brullo in the Mediterranean region

2015

Change in growth is among the primary response of trees to environmental variation. Tree-rings contain a wealth of information related to the climatic conditions. A dendroclimatic study on Quercus gussonei (Borzì) Brullo was carried out in the Nature Reserve of “Bosco della Ficuzza, Rocca Busambra, Bosco Del Cappelliere, Gorgo Del Drago” (southern Italy). Q. gussonei is an endemic deciduous oak and thermophilous form of Quercus cerris L. that is found only in Sicily, although with clear sign of decline. The knowledge of ecology of this species should help to establish criteria for forest conservation in the Mediterranean region. For definining the ecological character and understanding the …

Loquat decline in Italy caused by botriosphaeriaceus fungi

2016

Recovery of cork forests and enhancement of by-products

2022

Cork oak (Quercus suber L.) is a tree species native to the western Mediterranean Basin (EUFORGEN 2019). Cork oak forests are human-shaped ecosystems that have to be managed to be preserved in a long-term perspective. Cork oak stands range from closed forests to open woodlands, provide high ecosystem services, mainly through cork production, support high biodiversity and provide carbon storage and water regulation services. Due to their important ecological role, these ecosystems are listed in the European Habitats Directive (Habitat 9330: Quercus suber forests, EEC, 1992). In the last years, especially in Italy, cork oak stands are undergoing a relevant regression due to the decline of tra…

L'Orchestra di Auschwitz. Inchiesta su Alma Rosé

2023

Il libro è un'inchiesta sulla vita e il tempo di Alma Rosé (1906-1944), nipote di Gustav Mahler, debuttante e ragazza alla moda fra gli anni Venti e Trenta del secolo scorso, violinista il cui talento matura – paradossalmente – mentre l’ombra del nazismo si dispiega sull’Europa e infine direttrice dell’orchestra di Auschwitz. in un’epoca in cui la carriera del direttore d’orchestra era declinata soltanto al maschile. Giunta ad Auschwitz nell’estate 1943 e assegnata dapprima al Block degli esperimenti medici, Alma riuscì in breve tempo a diventare – nel piccolo mondo terribile del Lager – una specie di celebrità: ed è in quelle tenebre, d’altronde, che si svolge l’atto finale del dramma, oss…