Search results for " Delayed"

showing 10 items of 205 documents

Determinants of interest in extended-released buprenorphine: A survey among 366 French patients treated with buprenorphine or methadone

2021

International audience; Aim: To explore the factors determining the interest in extended-release buprenorphine (XR-BUP) injections among patients receiving opioid agonist treatment (OAT) in France.Methods: 366 patients receiving OAT for opioid use disorder, recruited in 66 French centers, were interviewed from 12/2018 to 05/2019. A structured questionnaire assessed their interest in XR-BUP using a [1-10] Likert scale. 'More' vs. 'less' interested groups were defined using the median score of interest, and their characteristics were explored using adjusted odds ratios (aORs) and 95 % confidence interval (95 %CI). Independent variables were as follows: sociodemographic characteristics, OAT-re…

MaleNarcotic Antagonists[SDV]Life Sciences [q-bio]ToxicologyMESH: Analgesics Opioid0302 clinical medicineInterquartile rangeSurveys and QuestionnairesPharmacology (medical)030212 general & internal medicineSurveymedia_commonMESH: Patient PreferenceMESH: Middle AgedOpioid use disorderPatient PreferenceMiddle AgedBuprenorphineAnalgesics OpioidPsychiatry and Mental healthMESH: Young AdultFemaleFranceMESH: Narcotic AntagonistsPatients' preferencemedicine.drugAdultmedicine.medical_specialtyAdolescentMESH: Delayed-Action Preparationsmedia_common.quotation_subjectMESH: BuprenorphineMESH: Opiate Substitution TreatmentInjections03 medical and health sciencesYoung AdultInternal medicinemedicineOpiate Substitution TreatmentHumansMESH: InjectionsDosingMESH: Surveys and QuestionnairesPharmacologyMESH: AdolescentMESH: Humansbusiness.industryMESH: AdultOdds ratioAbstinencemedicine.diseaseOpioid-Related DisordersConfidence intervalMESH: MaleMESH: Opioid-Related DisordersMESH: FranceDelayed-Action PreparationsMESH: MethadoneExtended-releasebusinessMESH: Female030217 neurology & neurosurgeryMethadoneMethadoneBuprenorphine
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Changes in parental smoking during pregnancy and risks of adverse birth outcomes and childhood overweight in Europe and North America

2020

Background Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, specifically of quitting or reducing smoking and maternal and paternal smoking combined, with preterm birth, small size for gestational age, and childhood overweight. Methods and findings We performed an individual participant data meta-analysis among 229,158 families from 28 pregnancy/bir…

MaleParentsembarazoEpidemiologyMaternal HealthSocial SciencesCHILDREN0302 clinical medicinePregnancynacimiento prematuroSmoking/adverse effectsPsychologyMATERNAL SMOKINGestudios de cohortesBody mass indexeducation.field_of_studyGeneral MedicineASSOCIATION16. Peace & justice3. Good healthPrenatal Exposure Delayed EffectsMedicineGROWTHefectos diferidos por exposición prenatalCohort studyHumanPRETERM BIRTHEurope/epidemiology03 medical and health sciencesHumansSmoking habitsRisk factoreducationBehaviorPregnancyBiology and Life SciencesInfantOdds ratiohábito de fumarmedicine.diseasePregnancy ComplicationsCESSATIONDemographyPediatric ObesityPhysiologyhumanos030204 cardiovascular system & hematologyOverweightNorth America/epidemiologyCohort StudiesHabitsRisk FactorsMedicine and Health Sciences030212 general & internal medicineDNA METHYLATIONSmokingRObstetrics and GynecologyGestational ageedad gestacionalPrenatal Exposure Delayed Effects/diagnosis3142 Public health care science environmental and occupational healthobesidad pediátricaPediatric Obesity/diagnosisEuropePhysiological ParametersCohort Studies; Europe; Female; Gestational Age; Humans; Infant Newborn; Male; North America; Pediatric Obesity; Pregnancy; Premature Birth; Prenatal Exposure Delayed Effects; Risk Factors; Smoking; ParentsOBESITYPremature BirthFemalemedicine.symptomResearch ArticleBirth weightPopulationPremature Birth/diagnosisGestational AgepadresPrenatal Exposure Delayed EffectHealthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]All institutes and research themes of the Radboud University Medical CenterBirth weightmedicinefactores de riesgoEXPOSURElactantebusiness.industryRisk FactorBody WeightInfant NewbornOverweightNewbornReconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]Medical risk factors3121 General medicine internal medicine and other clinical medicineNorth AmericaBirthWomen's HealthWEIGHTCohort Studiebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyPLOS Medicine
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Clinical features and follow-up in patients with 22q11.2 deletion syndrome

2014

Objective To investigate the clinical manifestations at diagnosis and during follow-up in patients with 22q11.2 deletion syndrome to better define the natural history of the disease. Study design A retrospective and prospective multicenter study was conducted with 228 patients in the context of the Italian Network for Primary Immunodeficiencies. Clinical diagnosis was confirmed by cytogenetic or molecular analysis. Results The cohort consisted of 112 males and 116 females; median age at diagnosis was 4 months (range 0 to 36 years 10 months). The diagnosis was made before 2 years of age in 71% of patients, predominantly related to the presence of heart anomalies and neonatal hypocalcemia. In…

MalePediatrics22q11.2 deletionDelayed DiagnosisTime FactorsChromosomes Human Pair 22Developmental Disabilitiesdigeorge syndromeSex FactorSeverity of Illness IndexRetrospective StudieDiGeorge syndromeEarly DiagnosiAge FactorProspective StudiesNeonatal hypocalcemiaProspective cohort studyChildmedicine.diagnostic_testDelayed Diagnosi22q11.2 deletion; Primary immune disordersAge Factorsdel 22qMIMAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease ProgressionChild PreschoolCohortDisease ProgressionPrimary immune disordersFemaleAbnormalitiesMultipleAbnormalities Multiple; Adolescent; Adult; Age Factors; Child; Child Preschool; Chromosomes Human Pair 22; Delayed Diagnosis; Developmental Disabilities; DiGeorge Syndrome; Early Diagnosis; Female; Follow-Up Studies; Genetic Testing; Humans; Infant; Infant Newborn; Male; Monitoring Physiologic; Prospective Studies; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Factors; Time Factors; Young Adult; Disease Progression; Pediatrics Perinatology and Child HealthHumanAdultmedicine.medical_specialtyTime FactorAdolescentMonitoringDevelopmental DisabilitieItalian Association of Pediatric Haematology and OncologyContext (language use)Risk AssessmentChromosomesFollow-Up StudieYoung AdultSex FactorsSeverity of illnessmedicineDiGeorge SyndromeHumansAbnormalities MultipleGenetic Testing22q11DS; 22q11.2 deletion syndrome; AIEOP; Italian Association of Pediatric Haematology and Oncology; MIM; Mendelian Inheritance in Man22q11DSPreschoolPhysiologicdigeorge syndrome; del 22qGenetic testingMonitoring PhysiologicRetrospective StudiesSettore MED/38 - Pediatria Generale e Specialisticabusiness.industryMendelian Inheritance in ManInfant NewbornInfantRetrospective cohort studymedicine.diseaseNewbornAIEOPProspective StudieEarly Diagnosis22q11.2 deletion syndromePediatrics Perinatology and Child HealthPair 22businessFollow-Up Studies
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Thyroid Function in Early Pregnancy, Child IQ, and Autistic Traits: A Meta-Analysis of Individual Participant Data

2018

Context: Low maternal free T4 (FT4) has been associated with poor child neurodevelopment in some single-center studies. Evidence remains scarce for the potential adverse effects of high FT4 and whether associations differ in countries with different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting, and Participants: Meta-analysis of individual participant data from 9036 mother–child pairs from three prospective population-based birth cohorts: INMA [Infancia y Medio Ambiente (Environment and Childhood project) (Spain)], Generation R (Netherlands), and AL…

MalePediatricsEndocrinology Diabetes and MetabolismIntelligenceClinical BiochemistryThyroid GlandThyrotropinThyroid Function TestsBiochemistryChild Development0302 clinical medicineEndocrinologyPregnancyRisk FactorsLongitudinal Studies030212 general & internal medicineYoung adultChildeducation.field_of_studymedicine.diagnostic_testThyroid disease3. Good healthChild PreschoolPrenatal Exposure Delayed EffectsFemaleGeneration RThyroid functionAdultmedicine.medical_specialtyPopulationMothersGestational Age030209 endocrinology & metabolismThyroid function testsYoung Adult03 medical and health sciencesInternal medicinemedicineHumansAutistic DisordereducationPregnancybusiness.industryBiochemistry (medical)Infantmedicine.diseaseThyroid DiseasesChild developmentPregnancy ComplicationsPregnancy Trimester FirstThyroxineEndocrinologybusinessJournal of Clinical Endocrinology and Metabolism
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Prenatal exposure to mercury and neuropsychological development in young children: the role of fish consumption

2017

Background: Vulnerability of the central nervous system to mercury exposure is increased during early development. The aim of this study is to evaluate the association between prenatal exposure to mercury and child neuropsychological development in high-fish-intake areas in Spain. Methods: Study subjects were 1362 children, participants in the INMA (Environment and Childhood) birth cohort study. Cord blood total mercury (CB-Hg) and cord polyunsaturated fatty acids (PUFA) concentrations were analysed in samples collected between 2004 and 2008. Child neuropsychological development was assessed at age 4-5 years by the McCarthy Scales of Children's Abilities (MSCA). Socio-demographic, lifestyle…

MalePediatricsEpidemiology010501 environmental sciencesNeuropsychological Tests01 natural sciencesCohort Studies0302 clinical medicineChild DevelopmentPregnancy030212 general & internal medicinechemistry.chemical_classificationneurodevelopmentNeuropsychologymethylmercuryGeneral MedicineMaternal ExposureCord bloodChild PreschoolPrenatal Exposure Delayed EffectsFatty Acids UnsaturatedFemalePolyunsaturated fatty acidAdultmedicine.medical_specialtyCordchemistry.chemical_elementfatty acids03 medical and health sciencesYoung AdultchildrenmedicineAnimalsHumanschildren diet fatty acids fish consumption methylmercury neurodevelopment neurotoxicantneurotoxicant0105 earth and related environmental sciencesPregnancybusiness.industryfish consumptionMercurymedicine.diseaseFish consumptionConfidence intervalMercury (element)chemistrySeafoodSpainMultivariate AnalysisLinear Modelsbusinessdiet
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Maternal Consumption of Seafood in Pregnancy and Child Neuropsychological Development: A Longitudinal Study Based on a Population With High Consumpti…

2016

Seafood consumption during pregnancy is thought to be beneficial for child neuropsychological development, but to our knowledge no large cohort studies with high fatty fish consumption have analyzed the association by seafood subtype. We evaluated 1,892 and 1,589 mother-child pairs at the ages of 14 months and 5 years, respectively, in a population-based Spanish birth cohort established during 2004-2008. Bayley and McCarthy scales and the Childhood Asperger Syndrome Test were used to assess neuropsychological development. Results from multivariate linear regression models were adjusted for sociodemographic characteristics and further adjusted for umbilical cord blood mercury or long-chain p…

MalePediatricsLongitudinal studyEpidemiologyNeuropsychological TestsNeuropsychological development010501 environmental sciences01 natural sciencesChild DevelopmentCognition0302 clinical medicinePregnancyBayesian multivariate linear regressionPopulation-based birth cohortsLongitudinal Studies030212 general & internal medicineAutistic spectrumPrenatal Nutritional Physiological Phenomenachemistry.chemical_classificationeducation.field_of_studyChild PreschoolPrenatal Exposure Delayed EffectsFatty Acids UnsaturatedFemalepregnancyPolyunsaturated fatty acidautistic spectrumAdultmedicine.medical_specialtymercuryOffspringPopulationPeixos -- Alimentaciófatty acidsseafood intake03 medical and health sciencesEmbaràs -- Aspectes nutricionalsneuropsychological developmentmedicineHumansFatty acidseducationpopulation-based birth cohorts0105 earth and related environmental sciencesPregnancybusiness.industrySeafood intakeInfantMercurymedicine.diseaseConfidence intervalSeafoodchemistryNeurodevelopmental DisordersSpainAsperger's disorderAutismebusinessDemography
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Gender-Dependent Effect of GSTM1 Genotype on Childhood Asthma Associated with Prenatal Tobacco Smoke Exposure

2014

It remains unclear whether the GSTM1 genotype interacts with tobacco smoke exposure (TSE) in asthma development. This study aimed to investigate the interactions among GSTM1 genotype, gender, and prenatal TSE with regard to childhood asthma development. In a longitudinal birth cohort in Taiwan, 756 newborns completed a 6-year follow-up, and 591 children with DNA samples available for GSTM1 genotyping were included in the study,and the interactive influences of gender-GSTM1 genotyping-prenatal TSE on childhood asthma development were analyzed. Among these 591 children, 138 (23.4%) hadphysician-diagnosed asthmaat 6 years of age, and 347 (58.7%) werenull-GSTM1. Prenatal TSE significantly incre…

MalePediatricsmedicine.medical_specialtyArticle Subjectanimal diseasesTaiwanlcsh:MedicineComorbidityLower riskPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyPregnancyRisk FactorsGenotypePrevalencemedicineHumansGenetic Predisposition to DiseaseSex DistributionChildneoplasmsGenotypingGlutathione TransferaseAsthmaChildhood asthmaintegumentary systemGeneral Immunology and Microbiologybusiness.industrylcsh:RTobacco smoke exposureInfant NewbornInfantTotal igeGeneral Medicinemedicine.diseaseAsthmanervous system diseasesCausalityChild PreschoolPrenatal Exposure Delayed EffectsFemaleTobacco Smoke PollutionbusinessBirth cohortResearch ArticleBioMed Research International
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Vitamin D in Pregnancy and Attention Deficit Hyperactivity Disorder-like Symptoms in Childhood

2015

Vitamin D status during prenatal brain development may influence risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. However, there are no prospective studies addressing this hypothesis. We aimed to examine whether maternal vitamin D status in pregnancy is associated with risk of ADHD-like symptoms in offspring.We conducted a prospective study analyzing data from 1,650 mother-child pairs from five birth cohorts embedded in the INMA Project (Spain, 1997-2008). Maternal vitamin D status in pregnancy was estimated by measuring plasma concentration of 25-hydroxyvitamin D3 [25(OH)D3] at 13 weeks of gestation. Children were assessed by teachers for ADHD-like symptom…

MalePediatricsmedicine.medical_specialtyEpidemiologyMEDLINECohort StudiesPregnancyVitamin D and neurologymedicineHumansAttention deficit hyperactivity disorderProspective StudiesProspective cohort studyCalcifediolPregnancybusiness.industryIncidenceIncidence (epidemiology)Vitamin D Deficiencymedicine.diseasePregnancy ComplicationsPregnancy Trimester FirstAttention Deficit Disorder with HyperactivitySpainChild PreschoolPrenatal Exposure Delayed EffectsLinear ModelsAttention deficitFemalebusinessCohort studyEpidemiology
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Correction: Santa-Marina et al. Maternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y …

2021

Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children's ADHD-like symptoms at ages 4-5 years were assessed using the ADHD Rating Scale-IV. The count model of the zero-inflated Poisson regression model showed a significant inverse association between ferritin (continuous variable) and inattention, β = -0.19 …

MalePediatricsmedicine.medical_specialtyHealth Toxicology and MutagenesisFerritin levels010501 environmental sciences01 natural sciencesCohort Studies03 medical and health sciencesSex Factors0302 clinical medicinePregnancymedicineHumansProspective Studies030212 general & internal medicineAdhd symptoms0105 earth and related environmental sciencesPregnancybusiness.industryPublic healthINTPublic Health Environmental and Occupational HealthRCorrectionmedicine.disease3. Good healthn/aAttention Deficit Disorder with HyperactivitySpainChild PreschoolPrenatal Exposure Delayed EffectsFerritinsRegression AnalysisMedicineFemalebusinessBirth cohortInternational Journal of Environmental Research and Public Health
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Prenatal exposure to fluoride and neuropsychological development in early childhood: 1-to 4 years old children

2022

[EN]BACKGROUND: Cross-sectional and prospective studies have provided evidence of the neurotoxic effect of early exposure to fluoride (F) in pregnancy. It has been negatively associated with cognitive development during childhood, with most research conducted in areas with high F levels in community drinking water (CDW). METHOD: Data from 316 to 248 mother-child pairs from the Infancia y Medio Ambiente (Childhood and Environment, INMA) birth cohort project with maternal urinary F level adjusted for creatinine (MUFcr) measurements in the first and third trimesters of pregnancy. Children's cognitive domains and intelligence indexes were evaluated using the Bayley Scales (age of 1) and the McC…

MalePopulationIntelligenceContext (language use)Neuropsychological developmentBiochemistryBayley Scales of Infant DevelopmentFluoridesChild Developmentchildrenneuropsychological developmentPregnancymedicineCognitive developmentHumansProspective StudiesEarly childhoodProspective cohort studyeducationFluorideChildrenGeneral Environmental SciencePregnancyeducation.field_of_studyfluoridebusiness.industryNeuropsychologyInfantintelligencemedicine.diseaseCross-Sectional StudiesChild PreschoolPrenatal Exposure Delayed EffectsFemalepregnancybusinessDemography
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