Search results for " Depressive disorder"
showing 10 items of 133 documents
Minor depression in adolescence: phenomenology and clinical correlates.
2006
Abstract Background Depressions that fail to meet the diagnostic criteria for major depressive disorder (MDD) may be underdiagnosed and undertreated in adolescent population. Traditionally, they are not considered as serious conditions and the phenomenological nature and clinical correlates of these disorders are largely unknown. In the present study, we used a large, representative and age-standardized sample of adolescents to examine the phenomenology and clinical correlates of minor depression, a poorly understood condition included in the category of Depressive Disorder Not Otherwise Specified in Diagnostic and Statistical Manual of Mental Disorders–Fourth Edition–Text Revised (DSM-IV-T…
Association Between Citalopram Serum Levels and Clinical Improvement of Patients With Major Depression
2011
Imaging studies have shown that serum concentrations of the selective serotonin reuptake inhibitor citalopram correlate with serotonin transporter (5-HTT) occupancy in vivo. In patients with major depressive disorders treated with citalopram, 80% 5-HTT occupancy was considered to be necessary for maximal therapeutic effects, which requires citalopram serum concentrations of at least 50 ng/mL. The aim of this study was to compare treatment outcome in patients with citalopram serum concentrations greater than and less than 50 ng/mL after 7 days of treatment. This study included inpatients with acute major depressive disorder according to International Classification of Disease, 10th Revision …
Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the rea…
2022
Abstract Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant Depression (TRD) according to sex in a precision-medicine approach. Method The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at 6 months. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at 6 months on their smoking and psychiatric hospitalization outcomes. Results…
The Physical and Mental Well-Being of Medical Doctors in the Silesian Voivodeship
2022
Physical and mental well-being are important determinants of medical doctors’ lives, including their professional activity, which has a direct impact on the health and lives of patients. The aim of the study was to assess the health condition of medical doctors from the Silesian Voivodeship. The physical health condition, including the prevalence of chronic diseases, drug therapy, and pro-health activities, was assessed. Data on mental health according to the HADS scale (hospital anxiety and depression scale) referred to the selected socio-economic and professional aspects of life, as well as life and job satisfaction. The doctors most often reported diseases of the circulatory system and d…
Intervención cognitivo conductual para mujeres con trastorno depresivo persistente: sintomatología ansiosa, depresiva y satisfacción vital
2021
Antecedentes. El trastorno depresivo persistente (TDP) es una afectación del estado de ánimo frecuente en mujeres. Se ha empleado la terapia cognitivo conductual (TCC), la terapia cognitiva basada en mindfulness y la terapia centrada en la compasión de forma aislada. Objetivos. Evaluar la eficacia de un programa de intervención grupal multicomponente. Método. Tras la firma del consentimiento informado, las participantes (n = 6) respondieron (pre, post intervención y seguimiento) cuestionarios sobre: ansiedad, depresión, satisfacción con la vida y satisfacción con la intervención. Resultados. Nuestros resultados previos al tratamiento muestran niveles elevados de sintomatología ansiosa y dep…
MFCC-based Recurrent Neural Network for automatic clinical depression recognition and assessment from speech
2022
Abstract Clinical depression or Major Depressive Disorder (MDD) is a common and serious medical illness. In this paper, a deep Recurrent Neural Network-based framework is presented to detect depression and to predict its severity level from speech. Low-level and high-level audio features are extracted from audio recordings to predict the 24 scores of the Patient Health Questionnaire and the binary class of depression diagnosis. To overcome the problem of the small size of Speech Depression Recognition (SDR) datasets, expanding training labels and transferred features are considered. The proposed approach outperforms the state-of-art approaches on the DAIC-WOZ database with an overall accura…
Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes.
2021
Abstract Background Treatment resistant depression (TRD) characterizes a subgroup of 10–30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. Methods This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on trea…
Mood congruence effect in explicit and implicit memory tasks: a comparison between depressed patients, schizophrenic patients and controls
1993
Summary This study investigates mood congruence effect in explicit and implicit memory tasks in 23 inpatients fulfilling DSM-III-R criteria for major depressive disorder. Performances were compared to those of 15 in- or outpatients fulfilling DSM-III-R criteria for schizophrenia, and 37 normal subjects serving as euthymics controls. All subjects were submitted to a standard cued recall test and to a word stem completion test devised to assess the effect of the initial presentation without the explicit retrieval of the words being necessary. The material used for these two tasks consisted of emotionally negative and positive words. The results show a mood congruence effect in the ```implicit…
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia
2020
Abstract Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. Methods We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results wer…
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder
2018
Psychiatric disorders are thought to have a complex genetic pathology consisting of interplay of common and rare variation. Traditionally, pedigrees are used to shed light on the latter only, while here we discuss the application of polygenic risk scores to also highlight patterns of common genetic risk. We analyze polygenic risk scores for psychiatric disorders in a large pedigree (n ~ 260) in which 30% of family members suffer from major depressive disorder or bipolar disorder. Studying patterns of assortative mating and anticipation, it appears increased polygenic risk is contributed by affected individuals who married into the family, resulting in an increasing genetic risk over generat…