Search results for " Design"
showing 10 items of 5050 documents
Improving Dissolution Behavior and Oral Absorption of Drugs with pH-Dependent Solubility Using pH Modifiers: A Physiologically Realistic Mass Transpo…
2021
Orally dosed drugs must dissolve in the gastrointestinal (GI) tract before being absorbed through the epithelial cell membrane. In vivo drug dissolution depends on the GI tract's physiological conditions such as pH, residence time, luminal buffers, intestinal motility, and transit and drug properties under fed and fasting conditions (Paixao, P. et al. Mol. Pharm. 2018 and Bermejo, et al. M. Mol. Pharm. 2018). The dissolution of an ionizable drug may benefit from manipulating in vivo variables such as the environmental pH using pH-modifying agents incorporated into the dosage form. A successful example is the use of such agents for dissolution enhancement of BCS class IIb (high-permeability,…
Estimation of ADME Properties in Drug Discovery: Predicting Caco-2 Cell Permeability Using Atom-Based Stochastic and Non-stochastic Linear Indices
2007
The in vitro determination of the permeability through cultured Caco-2 cells is the most often-used in vitro model for drug absorption. In this report, we use the largest data set of measured P(Caco-2), consisting of 157 structurally diverse compounds. Linear discriminant analysis (LDA) was used to obtain quantitative models that discriminate higher absorption compounds from those with moderate-poorer absorption. The best LDA model has an accuracy of 90.58% and 84.21% for training and test set. The percentage of good correlation, in the virtual screening of 241 drugs with the reported values of the percentage of human intestinal absorption (HIA), was greater than 81%. In addition, multiple …
Accuracy combining different brands of implants and abutments
2013
Objective: To evaluate the vertical misfit between different brands of dental implants and prosthetic abutments, with or without mechanical torque, and to study their possible combination. Study design: Five different brands of implant were used in the study: Biofit (Castemaggiore, Italy), Bioner S.A. (Barcelona, Spain), 3i Biomet (Palm Beach, U.S.A.), BTI (Alava, Spain) and Nobel Biocare (Göteborg, Sweden), with standard 4.1 mm heads and external hexagons, and their respective machined prosthetic abutments. The implant-to- abutment fit/misfit was evaluated at four points (vestibular, lingual/palatine, mesial and distal) between implants and abutments of the same brand and different brands,…
Museos para todos: la traducción e interpretación para entornos multimodales como herramienta de accesibilidad universal
2012
This article is the English version of “Museos para todos. La traducción e interpretación para entornos multimodales como herramienta de accesibilidad universal” by Catalina Jiménez Hurtado, Claudia Seibel & Silvia Soler Gallego. It was not published on the print version of MonTI for reasons of space. The online version of MonTI does not suffer from these limitations, and this is our way of promoting plurilingualism. Audiovisual Translation (AVT) has a scientific responsibility to develop analytical methodologies for the textual phenomenon of multimodality, and for the translation strategies associated with it. At the same time, it should aim to provide studies of universal accessibility wi…
MDP-Based Resource Allocation Scheme Towards a Vehicular Fog Computing with Energy Constraints
2018
As mobile applications deliver increasingly complex functionalities, the demands for even more intensive computation would quickly transcend energy capability of mobile devices. On one hand and in an attempt to address such issues, fog computing paradigm is introduced to mitigate the limited energy and computation resources available within constrained mobile devices, by moving computation resources closer to their users at the edge of the access network. On another hand, most of electric vehicles (EVs), with increasing computation, storage and energy capabilities, spend more than 90% of time on parking lots. In this paper, we conceive the basic idea of using the underutilized computation r…
Proportional and Preemption-Enabled Traffic Offloading for IP Flow Mobility: Algorithms and Performance Evaluation
2018
IP Flow Mobility (IFOM) enables a user equipment to offload data traffic at the IP flow level. Although the procedure of IFOM-based flow offloading has been specified by 3GPP, how many IP flows should be offloaded and when offloading should be performed are not defined. Consequently, IP flows may be routed to a target access network which has a strong signal strength but with backhaul congestion or insufficient access capability. In this paper, we propose two algorithms, referred to as proportional offloading (PO), and proportional and preemption-enabled offloading (PPO), respectively, for IP flow offloading in hybrid cellular and wireless local area networks. The PO algorithm decides an op…
Phone-Controlled Delivery of NGN Services into Residential Environments
2008
The horizontally layered architecture of the IMS/NGN standards family enables the delivery of services independent of access network and requesting device. In this article, the authors propose a further separation of service control and delivery, allowing the requesting device - in particular a user's mobile phone - to invite other devices (we will focus on DLNA appliances) into the service delivery, enhancing both user experience and service design flexibility. The proposed solution builds on exploiting proximity technologies (e.g. barcodes, NFC) for pairing the control device with a remote environment. Motivated by scenarios, the architecture concepts are explained and a prototype that wa…
Oltrepassare le soglie per accedere alla conoscenza del patrimonio
2021
Rendere accessibili i monumenti, come le opere maggiori e minori, che costituiscono il nostro patrimonio culturale significa dotarli di apposite soglie per oltrepassare quegli sbarramenti determinati dalla presenza di barriere sia fisiche sia culturali. Se per il superamento delle prime si interviene con interventi strutturali e architettonici che necessariamente devono essere gestiti da esperti di restauro, per il superamento delle barriere culturali entra in azione la disciplina del design della comunicazione visiva e con essa i designer in grado di adottare i corretti registri di traduzione dei contenuti in forme visuali di modo che questi possano essere fruiti da un pubblico ampio, in c…
Accurate estimation of retinal vessel width using bagged decision trees and an extended multiresolution Hermite model.
2012
We present an algorithm estimating the width of retinal vessels in fundus camera images. The algorithm uses a novel parametric surface model of the cross-sectional intensities of vessels, and ensembles of bagged decision trees to estimate the local width from the parameters of the best-fit surface. We report comparative tests with REVIEW, currently the public database of reference for retinal width estimation, containing 16 images with 193 annotated vessel segments and 5066 profile points annotated manually by three independent experts. Comparative tests are reported also with our own set of 378 vessel widths selected sparsely in 38 images from the Tayside Scotland diabetic retinopathy scre…
Design for social media engagement: Insights from elderly care assistance
2015
Abstract This paper explores an alternative view of design as an emergent process of engagement and learning, as opposed to the traditional view of systems design as a problem-solving tool. We focus on digitally enabled elderly support networks as an innovative approach to the design of elderly care assistance through social media. Our research project is conducted in the context of an Italian health-care institution and provides the empirical backdrop illustrating the ensemble artefact, the four design principles and the pragmatic outcomes of personalized elderly care interventions. These contributions add both practical and theoretical guidance and learning regarding social-media engageme…