Search results for " Diffuse"
showing 10 items of 65 documents
Special Issue “Smart Urban Lighting Systems”
2020
The design and operation of multifunctional infrastructures for public lighting as well as their impact on the urban environment and citizens’ life is today of great interest. The cost of energy for public lighting is often an issue for the budget of municipalities. Furthermore, researchers’ and designers’ attention is increasingly focused on aspects of public lighting not directly valuable through economic factors. Starting from the “quality” of the light environment, looking at citizens’ visual comfort, the light has to be considered as an instrument to improve the urban context and objects therein (including buildings). Indeed, urban degradation (lack of infrastructures, maintenance, ser…
CK2β-regulated signaling controls B cell differentiation and function
2023
Serine-Threonine kinase CK2 supports malignant B-lymphocyte growth but its role in B-cell development and activation is largely unknown. Here, we describe the first B-cell specific knockout (KO) mouse model of the β regulatory subunit of CK2. CK2βKO mice present an increase in marginal zone (MZ) and a reduction in follicular B cells, suggesting a role for CK2 in the regulation of the B cell receptor (BCR) and NOTCH2 signaling pathways. Biochemical analyses demonstrate an increased activation of the NOTCH2 pathway in CK2βKO animals, which sustains MZ B-cell development. Transcriptomic analyses indicate alterations in biological processes involved in immune response and B-cell activation. Upo…
Synthesis and antiproliferative activity of substituted 3[2-(1H-indol-3-yl)-1,3-thiazol-4-yl]-1H-pyrrolo[3,2-b]pyridines, marine alkaloid nortopsenti…
2014
A large number of indolyl-4-azaindolyl thiazoles, nortopsentin analogues, were conveniently synthesized. The antiproliferative activity of the new derivatives was examined against four human tumor cell lines with different histologic origin. Seven derivatives consistently reduced the growth of the experimental models independently of TP53 gene status and exhibited the highest activity against the malignant peritoneal mesothelioma (STO) cell line. The most active compound of this series acts as a CDK1 inhibitor, and was found to cause cell cycle arrest at G 2 /M phase, to induce apoptosis by preventing the phosphorylation of survivin in Thr 34 and to increase the cytotoxic activity of paclit…
U937 variant cells as a model of apoptosis without cell disintegration
2012
AbstractThe variant cell line U937V was originally identified by a higher sensitivity to the cytocidal action of tumor necrosis factor alpha (TNFα) than that of its reference cell line, U937. We noticed that a typical morphological feature of dying U937V cells was the lack of cellular disintegration, which contrasts to the formation of apoptotic bodies seen with dying U937 cells. We found that both TNFα, which induces the extrinsic apoptotic pathway, and etoposide (VP-16), which induces the intrinsic apoptotic pathway, stimulated U937V cell death without cell disintegration. In spite of the distinct morphological differences between the U937 and U937V cells, the basic molecular events of ap…
Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression al…
2002
AbstractGenomic aberrations in a series of paired biopsy samples from patients who presented initially with follicle center lymphoma (FCL) and subsequently transformed to diffuse large B-cell lymphoma (DLBCL) were measured by array comparative genomic hybridization (CGH). The consequences of these aberrations on gene expression were determined by comparison with expression analysis on these specimens using cDNA microarrays. A heterogeneous pattern of acquired genomic abnormalities was observed upon transformation, some of which were recurrent in small subsets of patients. Some of the genomic aberration acquired upon transformation, such as gain/amplification of 1q21-q24, 2p16 (REL/BCL11A ge…
Carbon dioxide diffuse emission and thermal energy release from hydrothermal systems at Copahue-Caviahue Volcanic Complex (Argentina)
2015
Fil: Chiodini, Giovanni. Istituto Nazionale di Geofisica e Vulcanologia, Sezione di Bologna. Bologna, Italia. Fil: Cardellini, Carlo. Università degli Studi di Perugia, Dipartimento di Fisica e Geologia. Perugia, Italy. Fil: Lamberti, María C. Universidad de Buenos Aires. Instituto de Estudios Andinos. Buenos Aires, Argentina. Fil: Agusto, Mariano. Universidad de Buenos Aires. Instituto de Estudios Andinos. Buenos Aires, Argentina. Fil: Caselli, Alberto Tomás Universidad Nacional de Río Negro. Instituto de Investigación en Paleobiología y Geología. Río Negro. Argentina. Fil: Liccioli, Caterina. Universidad de Buenos Aires. Instituto de Estudios Andinos. Buenos Aires, Argentina. Fil: Tambure…
Influenza della copertura superficiale sulle emissioni diffuse di metano da discarica: analisi di casi studio
2015
La quantizzazione delle emissioni di CH4 da discariche rappresenta un tema di rilievo nella gestione dei rifiuti. La capacità emissiva delle discariche, direttamente correlata alla decomposizione anaerobica della sostanza organica in esse smaltita, può durare per decine di anni sebbene la massima produzione di biogas si registra nei primi anni seguenti l’abbancamento dei rifiuti. Nella nota si riferisce dei risultati di alcune campagne di misura eseguite su discariche controllate per rifiuti urbani, dotate di differente tipo di copertura; in particolare, la prima discarica è dotata di capping definitivo, la seconda di capping temporaneo. I risultati ottenuti hanno evidenziato una significat…
Diffuse soil gas emissions of gaseous elemental mercury (GEM) from hydrothermal-volcanic systems: An innovative approach by using the static closed-c…
2016
This study was aimed to test a new methodological approach to carry out measurements of gaseous elemental mercury (GEM) diffusively emitted from soils in hydrothermal-volcanic environments. This method was based on the use of a static closed-chamber (SCC) in combination with a Lumex® RA-915M analyzer that provides GEM measurements in a wide range of concentrations (from 2 to 50,000 ng m-3). Gas samples were collected at fixed time intervals from the SCC positioned on the ground (time-series samples). The Lumex® inlet port was equipped with a three-way Teflon valve allowing the free entrance of air through a carbon trap, in order to: (i) prevent disturbance to the Lumex® operative flow rate …
A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines
2014
Cancer cell lines are a tremendous resource for cancer biology and therapy development. These multipurpose tools are commonly used to examine the genetic origin of cancers, to identify potential novel tumor targets, such as tumor antigens for vaccine devel-opment, and utilized to screen potential therapies in preclinical studies. Mutations, gene expression, and drug sensitivity have been determined for many cell lines using next-generation sequencing (NGS). However, the human leukocyte antigen (HLA) type and HLA expression of tumor cell lines, characterizations necessary for the development of cancer vaccines, have remained largely incomplete and, such information, when available, has been …
Total (fumarolic + diffuse soil) CO2 output from Furnas volcano
2015
Furnas volcano, in São Miguel island (Azores), being the surface expression of rising hydrothermal steam, is the site of intense carbon dioxide (CO2) release by diffuse degassing and fumaroles. While the diffusive CO2 output has long (since the early 1990s) been characterized by soil CO2 surveys, no information is presently available on the fumarolic CO2 output. Here, we performed (in August 2014) a study in which soil CO2 degassing survey was combined for the first time with the measurement of the fumarolic CO2 flux. The results were achieved by using a GasFinder 2.0 tunable diode laser. Our measurements were performed in two degassing sites at Furnas volcano (Furnas Lake and Furnas Villag…