Search results for " Disequilibrium"

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Analysis of HLA-DRB1,DQA1,DQB1 haplotypes in Sardinian centenarians

2008

Some genetic determinants of longevity might reside in those polymorphisms for the immune system genes that regulate immune responses. Many longevity association studies focused their attention on HLA (the human MHC) polymorphisms, but discordant results have been obtained. Sardinians are a relatively isolate population and represent a suitable population for association studies. Some HLA-DR and DQ alleles form very stable haplotypes with a strong linkage disequilibrium. In a previous study on Sardinian centenarians we have suggested that HLA-DRB1 *15 allele might be marginally associated to longevity. HLA-DR,DQ haplotypes are in strong linkage disequilibrium and well conserved playing a ro…

musculoskeletal diseasesAgingLinkage disequilibriummedia_common.quotation_subjectGenes MHC Class IILongevityPopulationBiologyBiochemistryArticleHLA-DQ alpha-ChainsLinkage Disequilibrium03 medical and health sciences0302 clinical medicineEndocrinologyGene FrequencyHLA-DQ AntigensGeneticsHLA-DQ beta-ChainsHumansskin and connective tissue diseaseseducationMolecular BiologyHLA-DRB1Allele frequencyComputingMilieux_MISCELLANEOUS030304 developmental biologyGenetic associationmedia_commonAged 80 and overGeneticsLikelihood Functions0303 health scienceseducation.field_of_studyPolymorphism GeneticHLA-DQB1HaplotypeLongevityHLA-DR AntigensCell BiologyHaplotypesItalyHLA Longevity SardiniaMedicineHLA-DRB1 Chains030215 immunologyExperimental Gerontology
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