Search results for " Domes"

Synthetic Polyclonal-Derived CDR Peptides as an Innovative Strategy in Glaucoma Therapy

2019

The pathogenesis of glaucoma is strongly associated with the occurrence of autoimmune-mediated loss of retinal ganglion cells (RGCs) and additionally, recent evidence shows that specific antibody-derived signature peptides are significantly differentially expressed in sera of primary-open angle glaucoma patients (POAG) compared to healthy controls. Synthetically antibody-derived peptides can modulate various effector functions of the immune system and act as antimicrobial or antiviral molecules. In an ex vivo adolescent glaucoma model, this study, for the first time, demonstrates that polyclonal-derived complementarity-determining regions (CDRs) can significantly increase the survival rate …

The European Regional Convergence Process, 1980-1995: Do Spatial Regimes and Spatial Dependence Matter?

2002

International audience; The authors show that spatial dependence and spatial heterogeneity matter in the estimation of the ß-convergence process among 138 European regions over the 1980 to 1995 period. Using spatial econometrics tools, the authors detect both spatial dependence and spatial heterogeneity in the form of structural instability across spatial convergence clubs. The estimation of the appropriate spatial regimes spatial error model shows that the convergence process is different across regimes. The authors also estimate a strongly significant spatial spillover effect: the average growth rate of per capita GDP of a given region is positively affected by the average growth rate of …

GENETIC DISTINCTIVENESS OF ITALIAN AUROCHS: NEW INSIGHT NTO CATTLE DOMESTICATION PROCESS

2008

Transpiration and Water Use of an Irrigated Traditional Olive Grove with Sap-Flow Observations and the FAO56 Dual Crop Coefficient Approach

2021

The SIMDualKc model was applied to evaluate the crop water use and the crop coefficient (Kc) of an irrigated olive grove (Olea europaea L.) located in Sicily, Italy, using experimental data collected from two crop seasons. The model applies the FAO56 dual Kc approach to compute the actual crop evapotranspiration (ETc act) and its components, i.e., the actual tree transpiration (Tc act), obtained through the basal crop coefficient (Kcb), and soil evaporation according to an evaporation coefficient (Ke). Model calibration was performed by minimizing the difference between the predicted Tc act and the observed daily tree transpiration measured with sap flow instrumentation (TSF field) acquired…

The impact of the 2008 economic crisis on the increasing number of young psychiatric inpatients.

2017

Abstract Background Little is published about the impact of the 2008 economic crisis on mental health services in Spain. Method An interrupted time series analysis was conducted to investigate a potential short-term association between the 2008 economic crisis and the number of psychiatric hospital admissions. The timing of the intervention (April 2008) was based on observed changes in Gross Domestic Product (GDP). Data on 1,152,880 psychiatric inpatients from the national Hospital Morbidity Survey, 69 months before and after the onset of the economic crisis (April 2008), were analyzed. Results Age-adjusted psychiatric (ICD9 290–319) hospital discharge rates significantly increased from Apr…

Prevalence of and potential influencing factors for alcohol dependence in Europe.

2014

Alcohol use disorders (AUDs), and alcohol dependence (AD) in particular, are prevalent and associated with a large burden of disability and mortality. The aim of this study was to estimate prevalence of AD in the European Union (EU), Iceland, Norway, and Switzerland for the year 2010, and to investigate potential influencing factors. The 1-year prevalence of AD in the EU was estimated at 3.4% among people 18-64 years of age in Europe (women 1.7%, men 5.2%), resulting in close to 11 million affected people. Taking into account all people of all ages, AD, abuse and harmful use resulted in an estimate of 23 million affected people. Prevalence of AD varied widely between European countries, and…

Farm-related exposures and childhood brain tumours in seven countries: results from the SEARCH International Brain Tumour Study.

2003

A total of 1218 cases of childhood brain tumours (CBT) and 2223 control subjects from the general population were included in a population-based case-control study conducted in nine centres in seven countries. Mothers were asked about farm- or agriculture-related exposures. Significantly elevated odds ratios (OR) for CBT were associated with children's personal and maternal prenatal exposure while living on a farm with pigs (child OR = 1.7, mother OR = 2.3), horses (child OR = 1.6, mother OR = 1.8), dogs (child OR = 1.5, mother OR = 1.5) and cats (child OR = 1.5, mother OR = 1.7). Children who were exposed to pigs, horses and cats combined, while living on a farm, had a threefold elevated O…

High Cryptosporidium prevalences in healthy Aymara children from the northern Bolivian Altiplano.

1998

The prevalence of Cryptosporidium infection was determined in four Aymara communities in the Bolivian Altiplano, between the city of La Paz and Lake Titicaca, at an altitude of 3,800-4,200 meters. Single stool specimens were randomly collected from 377 5-19-year-old students, all apparently asymptomatic. The total prevalence (31.6%) is possibly the highest reported among healthy humans (a maximum of 9.8% and 2.0% in coprologic surveys in underdeveloped and developed countries, respectively) and one of the highest even in symptomatic subjects. No significant age and sex differences were observed. Such an infection prevalence is probably related to the poor sanitation conditions, contaminated…

On the Macroeconomic Effect of Extortion: An Agent-Based Approach

2021

This work proposes an agent-based approach to study the effect of extortion on macroeconomic aggregates, despite the fact that there is little data on this criminal activity given its hidden nature. We develop a Bottom-up Adaptive Macroeconomics (BAM) model that simulates a healthy economy, including a moderate inflation and a reasonable unemployment rate, and test the impact of extortion on various macroeconomic signals. The BAM model defines the usual interactions among workers, firms and banks in labour, goods and credit markets. Subsequently, crime is introduced by defining the propensity of the poorest workers to become extortionists, as well as the efficiency of the police in terms of…

Reconstructing Bronze Age diets and farming strategies at the early Bronze Age sites of La Bastida and Gatas (southeast Iberia) using stable isotope …

2020

The El Argar society of the Bronze Age in the southeast of the Iberian Peninsula (2200–1550 cal BCE) was among the first complex societies in Europe. Its economy was based on cereal cultivation and metallurgy, it was organized hierarchically, and successively expanded its territory. Most of the monumentally fortified settlements lay on steeply sloped mountains, separated by fertile plains, and allowed optimal control of the area. Here, we explore El Argar human diets, animal husbandry strategies, and food webs using stable carbon and nitrogen isotope analysis of charred cereal grains as well as human and animal bone collagen. The sample comprised 75 human individuals from the sites of La Ba…