Search results for " Dose"

Dosimetry revisited for the HDR I192r brachytherapy source model mHDR-v2

2010

Purpose: Recently, the manufacturer of the HDR I 192 r mHDR-v2 brachytherapysource reported small design changes (referred to herein as mHDR-v2r) that are within the manufacturing tolerances but may alter the existing dosimetric data for this source. This study aimed to (1) check whether these changes affect the existing dosimetric data published for this source; (2) obtain new dosimetric data in close proximity to the source, including the contributions from I 192 r electrons and considering the absence of electronic equilibrium; and (3) obtain scatterdose components for collapsed cone treatment planning system implementation. Methods: Three different Monte Carlo(MC) radiation transport co…

An approach to using conventional brachytherapy software for clinical treatment planning of complex, Monte Carlo-based brachytherapy dose distributio…

2009

Certain brachytherapy dose distributions, such as those for LDR prostate implants, are readily modeled by treatment planning systems (TPS) that use the superposition principle of individual seed dose distributions to calculate the total dose distribution. However, dose distributions for brachytherapy treatments using high-Z shields or having significant material heterogeneities are not currently well modeled using conventional TPS. The purpose of this study is to establish a new treatment planning technique (Tufts technique) that could be applied in some clinical situations where the conventional approach is not acceptable and dose distributions present cylindrical symmetry. Dose distributi…

MO-D-AUD B-08: Treatment Planning for Complex Brachytherapy Dose Distributions Using High-Z Shields and Conventional Software

2008

Purpose: Certain brachytherapydose distributions, like for LDR prostate implants, are readily modeled by treatment planningsoftware using the superposition principle of individual seeds to replicate the total dose distribution. However, dose distributions for brachytherapy treatments using high‐Z shields are currently not well‐modeled using conventional software.Method and Materials:Dose distributions from complex brachytherapy plaques determined using Monte Carlo methods were used as input data, and included COMS‐based eye plaques using 125 I , 103 Pd , and 131 Cs ; 4–8cm diameter AccuBoost peripheral breast brachytherapy applicators from Advanced Radiation Therapy; and the 2 and 3cm diame…

Sex differences in estimation of time intervals and in reaction time are removed by moderate but not high doses of caffeine in coffee

2002

Estimation of the passage of time in the seconds-to-minutes range and reaction time are strongly dependent on a hypothetical internal clock. Dopamine is the neurotransmitter most closely related to the rate of this clock. Caffeine, probably the most consumed drug in the world, leads to an augmentation of dopamine neurotransmission. In this study coffee, which reproduces the conditions under which caffeine is normally ingested, containing 3, 75, 150 or 300 mg of caffeine, was given to healthy male and female volunteers. A computerized time estimation and reaction time test was carried out 50 min after ingestion. Sex differences in placebo control subjects (who took decaffeinated coffee with …

Assessment of DEMO WCLL breeding blanket primary heat transfer system isolation valve absorbed doses due to activated water

2020

Abstract Within the framework of the activities foreseen by the EUROfusion action on the cooling water activation assessment for a DEMO reactor equipped with a Water Cooled Lithium Lead Breeding Blanket (WCLL BB), the University of Palermo is involved in the investigation of the absorbed dose induced by the decay of nitrogen radioisotopes produced by water activation, in the main components (e.g. isolation valves) of both First Wall (FW) and Breeder Zone (BZ) cooling circuits. The aim of this work is to assess the spatial distribution of the absorbed dose in the DEMO Upper Pipe Chase (UPC), focusing the attention on the space neighbouring a typical isolation valve of the Primary Heat Transf…

Inverse response of polypropylene to gamma radiation under vacuum

1997

Abstract The effect of gamma radiation under vacuum on polypropylene is analysed on the basis of a simple kinetic model. The influence of the irradiation parameters, total absorbed dose and dose rate, on the rates of the main reactions occurring during irradiation, i.e. β-scission, addition to double bonds and termination, is studied. Using kinetic equations, and free radical and double bond balance relationships, we show that it is possible to rationalize the response of polypropylene to gamma radiation. In particular, on the basis of the mathematical solutions of these equations, we obtain the equation of an ‘inversion curve’, implicit function of the irradiation parameters, which gives t…

Pre-treatment with high doses of cocaine decreases the reinforcing effects of cocaine in the conditioned place preference paradigm.

2012

The aim of the present study was to determine if pre-exposure to high doses of cocaine can subsequently alter the rewarding effects of this drug. Adult male mice received a pretreatment of physiological saline, or 12.5 or 25 mg/kg of cocaine (one injection a day for five days). After an interval of six days without injections, the rewarding effects of low doses of cocaine (0.5, 1 or 1.5 mg/kg) were evaluated in the conditioned place preference (CPP) paradigm. Doses of 1 and 1.5 mg/kg induced a clear CPP in animals pre-treated with saline but were ineffective in those pre-treated with 25 mg/kg of cocaine. Only the dose of 1.5 mg/kg induced CPP in mice pre-treated with 12.5 mg/kg of cocaine. …

Temperature-toxicity relationships of fluvalinate (synthetic pyrethroid) on Procambarus clarkii (Girard) under laboratory conditions.

1988

Cytotoxicity and antimitotic activity of Rhinella schneideri and Rhinella marina venoms.

2019

Abstract Ethnopharmacological relevance Rhinella schneideri and Rhinella marina are toad venoms distributed in different parts of the world, including Brazil, Columbia and amazon. Venoms extracted from different species have many clinical applications such as antimicrobial cardiotonics and treatment of cancer. Aim of the study; In this study, we aim to investigate the effect of venoms extracted from R. schneideri and R. marina on cancer cells and verify possible mechanism of action. Material and method Cytotoxicity analyses was performed using the resazurin reduction assay, where different concentrations of venoms were tested against sensitive CCRF-CEM and P-gp overexpressing ADR/CEM5000 le…

Tumor cell specific toxicity of Inula helenium extracts.

2006

The aim of the research program was to identify botanical extracts with antineoplastic activity. In this respect extracts prepared from Inula helenium roots showed a remarkable activity. As evidenced by the MTT assay, the Inula helenium extract revealed a highly selective toxicity toward four different tumor cell lines (HT-29, MCF-7, Capan-2 and G1), but a much lower toxicity against healthy human peripheral blood lymphocytes (PBLs) from two donors. The extract-induced death of tumor cells was studied extensively by electron microscopy. There was a remarkable similarity of morphological alterations observed in the four cell lines: patchy chromatin condensations, cytoplasmic vesiculation, sw…