Search results for " Doxorubicin"

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A fluorescence study of the loading and time stability of doxorubicin in sodium cholate/PEO-PPO-PEO triblock copolymer mixed micelles

2019

Abstract Hypothesis Doxorubicin hydrochloride (DX) is one of the most powerful anticancer agents though its clinical use is impaired by severe undesired side effects. DX encapsulation in nanocarrier systems has been introduced as a mean to reduce its toxicity. Micelles of the nonionic triblock copolymers of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) (PEO-PPO-PEO), are very promising carrier systems. The positive charge of DX confines the drug to the hydrophilic corona region of the micelles. The use of mixed micelles of PEO-PPO-PEO copolymers and a negatively charged bile salt should favour the solubilization of DX in the apolar core region of the micelles. Experiments We st…

small angle X-raymacromolecular substances02 engineering and technology010402 general chemistry01 natural sciencesMicelledoxorubicinFluorescence spectroscopyfluorescence; doxorubicin; pluronics bile salts; dynamic light scattering; small angle X-ray; scattering drug-deliveryPolyethylene GlycolsBiomaterialsColloid and Surface ChemistryDynamic light scatteringX-Ray DiffractionScattering Small AngleCopolymerMicellesDrug CarriersAqueous solutionAntibiotics AntineoplasticSmall-angle X-ray scatteringChemistrytechnology industry and agricultureWaterdynamic light scatteringPoloxamer021001 nanoscience & nanotechnologySodium Cholate0104 chemical sciencesSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialspluronics bile saltsSpectrometry FluorescenceChemical engineeringSolubilityPropylene Glycolsscattering drug-deliveryfluorescenceNanocarriers0210 nano-technology
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