Search results for " Dual"
showing 10 items of 154 documents
Improved insulin sensitivity and secretion in prediabetic patients with adrenal insufficiency on dual-release hydrocortisone treatment: a 36-month re…
2018
OBJECTIVE Dual-release hydrocortisone (DR-HC) provides physiological cortisol exposure, leading to an improvement of anthropometric and metabolic parameters. The aim of the study was to evaluate the effects of DR-HC on insulin secretion and sensitivity and cardiometabolic risk, indirectly expressed by the visceral adiposity index (VAI). DESIGN AND PATIENTS Retrospective analysis of 49 patients, 13 with primary and 36 with secondary adrenal insufficiency (AI), respectively, on conventional glucocorticoid treatment at baseline and switched to DR-HC for 36 months. Overall, 24 patients had AI-pre-diabetes (impaired fasting glucose, impaired glucose tolerance and the combination), and 25 had AI-…
The mechanically-based approach to 3D non-local linear elasticity theory: Long-range central interactions
2010
Abstract This paper presents the generalization to a three-dimensional (3D) case of a mechanically-based approach to non-local elasticity theory, recently proposed by the authors in a one-dimensional (1D) case. The proposed model assumes that the equilibrium of a volume element is attained by contact forces between adjacent elements and by long-range forces exerted by non-adjacent elements. Specifically, the long-range forces are modelled as central body forces depending on the relative displacement between the centroids of the volume elements, measured along the line connecting the centroids. Further, the long-range forces are assumed to be proportional to a proper, material-dependent, dis…
A Non-Reductionist Physiologism: Nietzsche on Body, Mind and Consciousness
2013
This paper addresses the following questions from the point of view of Nietzsche’s philosophy: What is the mind, and which kind of relationship does it hold to the body? Accordingly, the aim of this paper is to show that Nietzsche’s philosophy suggested a view of the mind that allows to outline an alternative stance to both mentalism and physicalism, as well as to both dualism and reductionism. It is argued that Nietzsche’s rehabilitation of the body as the specific seat of the mind in opposition to the Cartesian supremacy of the Ego still is of a great interest for contemporary philosophy, since it is not equivalent either to a reversed form of Cartesian dualism or to a physicalist reducti…
Extropy: Complementary Dual of Entropy
2015
This article provides a completion to theories of information based on entropy, resolving a longstanding question in its axiomatization as proposed by Shannon and pursued by Jaynes. We show that Shannon's entropy function has a complementary dual function which we call "extropy." The entropy and the extropy of a binary distribution are identical. However, the measure bifurcates into a pair of distinct measures for any quantity that is not merely an event indicator. As with entropy, the maximum extropy distribution is also the uniform distribution, and both measures are invariant with respect to permutations of their mass functions. However, they behave quite differently in their assessments…
Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tum…
2021
Simple Summary Variable domains of heavy chain only antibodies are small proteins that can be used for tumor imaging and therapy upon conjugation of functional groups. As frequently used random conjugation techniques can decrease binding to the target of interest, site-specific conjugation of these functional groups is preferred. Here, we optimized site-specific conjugation of both a chelator for binding of a radiometal and a photosensitizer to epidermal growth factor receptor (EGFR) binding VHH 7D12. We characterized this dual-labeled VHH for nuclear imaging and targeted photodynamic therapy of EGFR-expressing tumors. Abstract Variable domains of heavy chain only antibodies (VHHs) are valu…
THE CAUCHY DUAL AND 2-ISOMETRIC LIFTINGS OF CONCAVE OPERATORS
2018
We present some 2-isometric lifting and extension results for Hilbert space concave operators. For a special class of concave operators we study their Cauchy dual operators and discuss conditions under which these operators are subnormal. In particular, the quasinormality of compressions of such operators is studied.
The hidden group structure of quantum groups: strong duality, rigidity and preferred deformations
1994
A notion of well-behaved Hopf algebra is introduced; reflexivity (for strong duality) between Hopf algebras of Drinfeld-type and their duals, algebras of coefficients of compact semi-simple groups, is proved. A hidden classical group structure is clearly indicated for all generic models of quantum groups. Moyal-product-like deformations are naturally found for all FRT-models on coefficients andC∞-functions. Strong rigidity (H bi 2 ={0}) under deformations in the category of bialgebras is proved and consequences are deduced.
Counting by Statistics on Search Trees: Application to Constraint Satisfaction Problems
1997
In 1975, Knuth proposed a simple statistical method for investigating search trees. We use this technique for estimating the number of solutions of constraint satisfaction problem CSP and boolean satisfiability problem SAT instances. We show that, depending on domain reductions, tree-based estimates have a lower variance than estimates based on uniform sampling from the search space. Nevertheless, because the variance remains extremely high in the general case, a confidence interval cannot be derived, but a lower bound of the number of solutions. These results are confirmed by many experiments.
On the duality between mechanistic learners and what it is they learn
1993
All previous work in inductive inference and theoretical machine learning has taken the perspective of looking for a learning algorithm that successfully learns a collection of functions. In this work, we consider the perspective of starting with a set of functions, and considering the collection of learning algorithms that are successful at learning the given functions. Some strong dualities are revealed.
New expressions for string loop amplitudes leading to an ultrasimple conception of string dynamics
1991
New expressions are derived for string loop amplitudes as overlap integrals of string wave functionals. They are shown to take the form of exchange terms coming from the Bose-Einstein symmetrization between string segments. One is thus led to the ultrasimple conception that string theory is basically free, and that ``string interactions'' are merely due to the fact that strings are composite objects with Bose-Einstein segments as constituents.