Search results for " Ductal"
showing 3 items of 123 documents
Sialolitiasis parotídea del conducto de Stensen
2006
La litiasis salival es una afectación consistente en la obstrucción mecánica de una glándula salival o de su conducto excretor, debido a la formación de concreciones calcáreas o sialolitos, lo que determina una ectasía salival, pudiendo provocar la dilatación posterior de la glándula. La sialolitiasis supone el 30 % de la patología salival y afecta principalmente a las glándulas submaxilares (83 a 94 %), seguida por la glándula parótida (4 a 10 %) y las glándulas sublinguales (1 a 7 %). En este trabajo presentamos el caso de un paciente varón de 45 años que presentaba mal olor y sabor de boca en el momento de las comidas y afecto de un cálculo salival a nivel del conducto de Stensen izquier…
DESIGN OF SF3B1 SUBUNIT MODULATORS OF THE SF3B SPLICEOSOME COMPLEX
2022
The subject of this dissertation is the search for new therapeutic strategies for pancreatic cancer and aims to implement a Drug Discovery process for the rational design and synthesis of molecules active in the modulation of pathways related to the regulation of pre-mRNA splicing process. This research project is the result of a joint PhD between the University of Palermo, Italy, and the Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands. It integrates complementary skills in pharmaceutical chemistry and translational cancer research with a special focus on the rational design of new anticancer compounds potentially active on SF3B1 (Splicing Factor 3B …
MTOR inhibitor-based combination therapies for pancreatic cancer
2018
Background: Although the mechanistic target of rapamycin (MTOR) kinase, included in the mTORC1 and mTORC2 signalling hubs, has been demonstrated to be active in a significant fraction of patients with pancreatic ductal adenocarcinoma (PDAC), the value of the kinase as a therapeutic target needs further clarification. Methods: We used Mtor floxed mice to analyse the function of the kinase in context of the pancreas at the genetic level. Using a dual-recombinase system, which is based on the flippase-FRT (Flp-FRT) and Cre-loxP recombination technologies, we generated a novel cellular model, allowing the genetic analysis of MTOR functions in tumour maintenance. Cross-species validation and pha…