Search results for " EFFICACY"
showing 10 items of 282 documents
School-based group intervention in attention and executive functions: Intervention response and moderators
2022
ObjectiveThis study investigated the effects of a school-based skill-training intervention in attention control and executive functions for pupils with hyperactivity-impulsivity (H-I) and cognitive control (CC) deficits. The main aim was to examine whether the intervention differently influenced H-I and CC, and whether cognitive abilities or conduct problems moderated response to the intervention.MethodElementary school pupils from 41 schools participated the study and were divided into an intervention group (n = 71) and a waitlist control group (n = 77). Intervention outcomes were assessed with an inventory assessing executive function difficulties (including H-I and CC) completed by class…
Sakarības starp stresa pārvarēšanas pašefektivitāti, pārliecību par taisnīgu pasauli, darba zaudējuma kognitīvo novērtējumu un depresiju bezdarbnieki…
2014
Anotācija Pētījuma mērķis bija izpētīt sakarības starp stresa pārvarēšanas pašefektivitāti, pārliecību par taisnīgu pasauli, darba zaudējuma kognitīvā novērtējuma dimensijām, sociāldemogrāfiskajiem faktoriem un depresiju 209 bezdarbnieku izlasē vecumā no 45 - 61 gadiem, un pārbaudīt, vai pastāv atšķirības pārliecību sistēmā starp bezdarbnieku grupu ar un bez depresijas simptomiem. Rezultāti parāda, ka respondentu grupām ar un bez depresijas pārliecības un kognitīvais novērtējums atšķiras . 42% no depresijas variācijas izskaidro attiecību statuss, kognitīvais zaudējuma novērtējums, personīgā pārliecība par taisnīgu pasauli un stresa pārvarēšanas pašefektivitāte. Kognitīvie faktori bezdarbnie…
Predicting physical activity change in cancer survivors: an application of the Health Action Process Approach.
2022
Purpose Previous research has not examined the utility of the Health Action Process Approach (HAPA) to predict physical activity (PA) change in cancer survivors. The aim of the study was to investigate the efficacy of a HAPA-based model in predicting temporal change in moderate-to-vigorous physical activity (MVPA) in cancer survivors. Methods Participants enrolled in the Wearable Activity Technology and Action Planning (WATAAP) trial completed validated questionnaires (n = 64) to assess HAPA constructs (action and maintenance self-efficacy, outcome expectancies, action planning, risk perceptions, and intention) and wore an ActiGraph to measure PA at baseline, 12 weeks, and 24 weeks later. D…
Adherence to omalizumab: A multicenter “real-world” study
2020
Background: Adherence to medications is crucial in patients with severe asthma in light of the negative clinical impact and costs of non-adherence. Adherence to omalizumab has not been well studied in real-world settings. The aim of this study was to assess adherence to omalizumab and evaluate treatment effectiveness in relation to adherence. Methods: This was a retrospective, observational, and multicenter real-world study. Omalizumab dose, timing of administration, and duration of treatment ( 4 years) were analyzed. Adherence was evaluated by examining rates of expected and missing doses. Good adherence (10% doses missed) were determined. For effectiveness in relation to adherence of omal…
Challenges in dental statistics: survey methodology topics
2022

 This paper gathers some contributions concerning survey methodology in dental research, as discussed during the first Workshop of the SISMEC STATDENT working group on statistical methods and applications in dentistry, held in Ancona on the 28th September 2011.
 The first contribution deals with the European Global Oral Health Indicators Development (EGOHID) Project which proposed a comprehensive and standardized system of epidemiological tools (questionnaires and clinical forms) for national data collection on oral health in Europe. The second contribution regards the design and conduct of trials to evaluate the clinical efficacy and safety of toothbrushes and mouthrinses. Final…
What happens after five years?: The long-term effects of a four-session Acceptance and Commitment Therapy delivered by student therapists for depress…
2017
Brief interventions can be viable treatment options worth consideration in addressing the growing need for treatments of subclinical and clinical depressive symptoms. However, there is uncertainty regarding the long-term benefits of these interventions. The aim was to examine the long-term (5-year) effects of a 4-session Acceptance and Commitment Therapy (ACT) intervention for low mood delivered by novice therapists in order to see whether lasting effects could be achieved cost-effectively with four intervention sessions. Originally, 57 self-referred clients were randomized into two groups: an intervention group and a waiting-list control group which received treatment later. The groups wer…
Assessing vaccine efficacy for the prevention of acute otitis media by pneumococcal vaccination in children: a methodological overview of statistical…
2006
Acute otitis media (AOM) is the most common bacterial infectious disease among children. Vaccination is proposed to prevent otitis and several clinical trials were performed to assess the efficacy of pneumococcal vaccines. The way vaccine efficacy is analysed varies among trials. However, the clinical meaning of an estimate of vaccine effect and its statistical test depends on the applied statistical method. We aim to bring the meaning and validity of statistical trial results to the attention of researchers. We consider all methodological approaches for analysing vaccine efficacy applied in pneumococcal vaccination trials included in a recent Cochrane Review. We demonstrate how different m…
Are licensed canine parvovirus (CPV2 and CPV2b) vaccines able to elicit protection against CPV2c subtype in puppies?: A systematic review of controll…
2015
Severe gastroenteritis caused by canine parvovirus type 2 (CPV2) is a serious life-threatening disease in puppies less than 4-months of age. The emergence of new variants has provoked some concern about the cross-protection elicited by licensed canine parvovirus modified-live type 2 (CPV2) and type 2b (CPV2b) vaccines against the most recent subtype CPV2c. A systematic review was carried out to assess the efficacy of commercial vaccines. We conducted a literature search of Pub Med/MEDLINE from January 1990 to May 2014. This was supplemented by hand-searching of related citations and searches in Google/Google Scholar. Controlled clinical trials in which vaccinated puppies were challenged wit…
Real life data on elbasvir/grazoprevir efficacy, safety and drug-drug interaction profile in patients with chronic hepatitis C viral infection: a pro…
2019
Introduction: In a previous study, based on PITER cohort data, it was reported that of patients, undergoing direct acting antiviral (DAA) therapy, 30%-44%, are at risk of potential drug-drug interactions (DDI). Aim: We aimed to evaluate the prospective profile of elbasvir/grazoprevir (EBR/GZR) efficacy and safety combined with real life comedication profile. Method: Data from 312 patients (mean age 63 ± 10 years; 44% male, 90% of genotype 1.85% fibrosis stage ≤ F3, 15% with child A cirrhosis), enrolled in PITER by 15 clinical centers and treated with EBR/GZR, with at least three months of follow up after the end of treatment, were evaluated. Comedication profiles (no changes, drugs interrup…
Link of the mechanisms of action of glatiramer acetate to its long-term clinical data
2009
A consequence of the long-term nature of progression in multiple sclerosis is that treatment needs to be provided over the long term. Gathering evidence for long term clinical efficacy, safety and patient acceptance of immunomodulatory therapies is thus a critically important issue. However, pivotal trials, which generally last no more than two years, cannot address this issue. Glatiramer acetate is the only immunomodulatory treatment for which prospective data is available covering a treatment period of over a decade. In the long-term extension of the pivotal trial of glatiramer acetate, 108 patients have been followed for a mean treatment duration of 10.1 years. At the end of the treatmen…