Search results for " END"

Rivalutazione delle caratteristiche cliniche e metaboliche di bambini con deficit isolato di ormone della crescita durante il trattamento con GH seco…

2015

Questo studio retrospettivo ha voluto valutare le caratteristiche cliniche e metaboliche di bambini con deficit di ormone della crescita (GHD) isolato, raggruppati secondo i nuovi criteri suggeriti dall’ Agenzia Italiana del Farmaco (AIFA) regolamentanti l’appropriatezza dell’uso e della rimborsabilità del trattamento con GH.

Studio randomizzato controllato, della durata di 2 anni, sugli effetti e la sicurezza di differenti dosaggi di r-hGH, titolati sulla base dei livelli…

2014

Trattamento delle steno-ostruzioni della biforcazione aorto-iliaca mediante la tecnica "kissing-stents"

2006

Relationship of oxidant stress with endothelial activation in hemodialysed hypertensive patients.

2006

Correlation between a marker of oxidative stress and a few indexes of endothelial dysfunction in essential hypertensive patients.

2005

Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity

2021

Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…

[177Lu]Lu-DOTA-TATE and [131I]MIBG Phenotypic Imaging-Based Therapy in Metastatic/Inoperable Pheochromocytomas and Paragangliomas: Comparative Result…

2022

PurposeThe aim of the study is to assess phenotypic imaging patterns and the response to treatment with [177Lu]Lu-DOTA-TATE and/or [131I]MIBG in paragangliomas (PGLs) and pheochromocytomas (PHEOs), globally and according to the primary location.MethodsThis is a 17-patient retrospective observational study, with 9 cases treated with [177Lu]Lu-DOTA-TATE and 8 with [131I]MIBG (37 total treatments). Functional imaging scans and treatment responses were studied in order to choose the best therapeutic option and to define the progression-free survival (PFS) and disease control rate (DCR) according to treatment modality and primary location.ResultsAll patients were studied with phenotypic nuclear …

Evidenza di una relazione inversa tra paratormone ed endotelina-1 in pazienti emodializzati

2007

Comparison of clinical and metabolic effects of pasireotide and pituitary surgery in Cushing disease

2017

Pituitary surgery represents the first-line treatment for most patients with Cushing’s disease (CD). In the case of surgery failure, additional treatment options are required. Pasireotide has shown favourable results in the first-line treatment of patients with CD, who are not candidates for surgery or in the second-line when surgery has failed. The aim of the current study is to compare the effects of surgery and pasireotide treatment in a cohort of patients with CD, and to evaluate the differences in response rate in terms of hormonal and clinical control, and improvement of metabolic complications.

Synthesis and Molecular Modeling Studies of Derivatives of a Highly Potent Peptidomimetic Vinyl Ester as Falcipain-2 Inhibitors

2012

Herein we report the synthesis of a set of constrained peptidomimetics endowed with an electrophilic vinyl ester warhead and structurally related to a previously identified lead compound, a potent and irreversible inhibitor of falcipain-2 (FP-2). FP-2 is the main hemoglobinase of the malaria parasite P. falciparum. The new compounds were evaluated for their inhibition against FP-2, and the results were rationalized on the basis of docking experiments. These studies underscore the pivotal role of both the ester function at the P1' site and the trifluoromethyl group of the P3 side chain in determining the correct orientation of the Michael acceptor warhead in the catalytic site, and as a cons…