Search results for " ETHANOL"
showing 10 items of 251 documents
Alternating current voltammetric determination of DNA damage
1990
Abstract The conditions for alternating current (a.c.) voltammetric DNA determinations have been investigated with respect to its use with alkaline filter elution techniques at low DNA concentrations. In inorganic electrolyte solutions three current peaks can be distinguished: peak I around −1.1 V caused by the reorientation or desorption of DNA segments; peak II around −1.2 V caused by the native DNA (nDNA) form; peak III caused by denatured DNA (dDNA) at −1.4 V. Sonication of nDNA increases the peak current, however not with dDNA. Both dDNA and nDNA give linear peak current increments with DNA increments, their regression lines cutting the concentration axis at the origin. In filter eluti…
TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders
2017
Background Inflammation during brain development participates in the pathogenesis of early brain injury and cognitive dysfunctions. Prenatal ethanol exposure affects the developing brain and causes neural impairment, cognitive and behavioral effects, collectively known as fetal alcohol spectrum disorders (FASD). Our previous studies demonstrate that ethanol activates the innate immune response and TLR4 receptor and causes neuroinflammation, brain damage, and cognitive defects in the developmental brain stage of adolescents. We hypothesize that by activating the TLR4 response, maternal alcohol consumption during pregnancy triggers the release of cytokines and chemokines in both the maternal …
Role of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice.
2021
Abstract Adolescence is a brain maturation developmental period during which remodeling and changes in synaptic plasticity and neural connectivity take place in some brain regions. Different mechanism participates in adolescent brain maturation, including autophagy that plays a role in synaptic development and plasticity. Alcohol is a neurotoxic compound and its abuse in adolescence induces neuroinflammation, synaptic and myelin alterations, neural damage and behavioral impairments. Changes in synaptic plasticity and its regulation by mTOR have also been suggested to play a role in the behavioral dysfunction of binge ethanol drinking in adolescence. Therefore, by considering the critical ro…
Binge ethanol drinking during adolescence modifies cocaine responses in mice
2016
Binge ethanol drinking is an emerging pattern of excessive consumption among adolescents and young adults. Repeated ethanol intoxication has negative consequences during critical periods of brain development. Therefore, binge ethanol intake represents a vulnerability factor that promotes subsequent manifestations of neuropsychiatric disorders. In this study, we investigated the effects of oral binge ethanol intake during adolescence on the subsequent effects of cocaine in C57BL/6 mice. Firstly, we evaluated the oral ethanol intake of two binge ethanol procedures with different ethanol concentrations (20% v/v versus 30%, v/v). The highest ethanol intake was found in mice exposed to the lowe…
Changes in histone acetylation in the prefrontal cortex of ethanol-exposed adolescent rats are associated with ethanol-induced place conditioning
2012
Alcohol drinking during adolescence can induce long-lasting effects on the motivation to consume alcohol. Abnormal plasticity in reward-related processes might contribute to the vulnerability of adolescents to drug addiction. We have shown that binge-like ethanol treatment in adolescent rats induces alterations in the dopaminergic system and causes histone modifications in brain reward regions. Considering that histone acetylation regulates transcriptional activity and contributes to drug-induced alterations in gene expression and behavior, we addressed the hypothesis that ethanol is capable of inducing transcriptional changes by histone modifications in specific gene promoters in adolescen…
From Wood and Hemp Biomass Wastes to Sustainable Nanocellulose Foams
2021
Abstract Transition to the circular economy requires the implementation of recycling and reuse routes for waste products. This research addresses one of the leading emerging areas, i.e., the development of sustainable materials and natural waste processing, namely wood and hemp byproducts. The cellulosic nanomaterials derived from these under-utilized waste residues and byproducts also serve as promising natural precursors for advanced applications, e.g., biomedical, pollution filtering, and thermal insulation. The wood and hemp fibrils were prepared by microfluidic processing of 0.2 – 1.0 wt% cellulose water suspensions. After freeze-drying, the resulting foam materials were characterized …
CCDC 705757: Experimental Crystal Structure Determination
2010
Related Article: K.Salorinne, D.P.Weimann, C.A.Schalley, M.Nissinen|2009|Eur.J.Org.Chem.|2009|6151|doi:10.1002/ejoc.200900814
Prediction of mass fluxes in the pervaporation process of the ethanol dehydration, based on the free volume theory
2014
Metodę obliczania współczynników dyfuzji Maxwella-Stefana opartą na współczynnikach dyfuzji własnej przewidywanych wg zależności wynikających z teorii wolnych objętości, zastosowano do obliczania strumieni masy w procesie perwaporacyjnego odwadniania etanolu na membranie z alkoholu poliwinylowego PVA. Parametry metody wolnych objętości dla badanego układu wyznaczono oraz obliczono stężenia równowagowe w PVA stosując zmodyfikowaną metodę UNIFAC-FV a następnie obliczono udziały masowe w permeacie oraz współczynniki wzbogacenia. Obliczenia przeprowadzono dla danych eksperymentalnych opublikowanych w pracy [3]. Wyniki obliczeń porównano z wynikami uzyskanymi na instalacji doświadczalnej.
The evolutionary scenario of hepatocellular carcinoma in Italy: an update
2017
Background and aims Epidemiology of hepatocellular carcinoma is changing worldwide. This study aimed at evaluating the changing scenario of etiology, presentation, management and prognosis of hepatocellular carcinoma in Italy during the last 15 years. Methods Retrospective analysis of the ITA.LI.CA (Italian Liver Cancer) database including 5192 hepatocellular carcinoma patients managed in 24 centers from 2000 to 2014. Patients were divided into three groups according to the date of cancer diagnosis (2000-2004, 2005-2009 and 2010-2014). Results The main results were: 1) progressive patient aging; 2) progressive expansion of non-viral cases and, namely, of “metabolic” hepatocellular carcinoma…
Microbial production of biopolymers from the renewable resource wheat straw.
2014
Aims Production of poly-s-hydroxybutyrate (PHB) and the chemical basic compound lactate from the agricultural crop ‘wheat straw’ as a renewable carbon resource. Methods and Results A thermal pressure hydrolysis procedure for the breakdown of wheat straw was applied. By this means, the wheat straw was converted into a partially solubilized hemicellulosic fraction, consisting of sugar monomers, and an insoluble cellulosic fraction, containing cellulose, lignin and a small portion of hemicellulose. The insoluble cellulosic fraction was further hydrolysed by commercial enzymes in monomers. The production of PHB from the sugar monomers originating from hemicellulose or cellulose was achieved by …