Search results for " EVALUATION"
showing 10 items of 1458 documents
WORKING CAPITAL AS AN ENTERPRISE VALUE ASSESSMENT TOOL
2019
The valuation of an entity in off-exchange transactions involves the use of different techniques. Nevertheless, none of them guarantees the most accurate result. Therefore, it is very difficult to choose one evaluation method. Both investors, corporate managers, financial professionals, portfolio managers, and securities analysts should have a basic understanding of the process of evaluating companies. To that end, professionals recommend evaluating a company’s financial reports to detect its financial position and solvency. According to the methods of financial analysis, working capital is one of the solvency ratios, which describes the value of resources that remain after the company’s cu…
Sorafenib perpetuates cellular anti-cancer effector functions by modulating the cross talk between macrophages and natural killer cells.
2012
Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor-directed natural killer (NK) cell responses. In vivo experiments were conducted with sorafenib (25 mg/kg)-treated C57BL/6 wildtype as well as hepatitis B virus (HBV) and lymphotoxin transgenic mice with and without HCC. Monocyte-derived Mϕ or tumor-associated macrophages (TAM) isolated from HCC tissue were treated with sorafenib (0.07-5.0 μg/mL) and cocultured with autologous NK cells. Mϕ and NK cell activation was analyzed …
Simultaneous screening and quantification of aminoglycoside antibiotics in honey using mixed-mode liquid chromatography with quadrupole time-of-fligh…
2018
An analytical method based on liquid chromatography with quadrupole time-of-flight mass spectrometry has been developed for the simultaneous determination of six aminoglycoside antibiotics in honey. The sample pretreatment included extraction with aqueous trichloroacetic acid followed by solid-phase extraction on Strata-X polymeric reversed phase cartridges. Liquid chromatography separation was performed on an Obelisc R zwitterionic type mixed-mode column. An ionBooster™ heated electrospray source was used and showed enhanced ionization efficiency in comparison to a conventional electrospray source. The observed signal enhancement ranged from 3- (neomycin) to 16-fold (gentamicin C1). A data…
Genetic contribution in sporadic thoracic aortic aneurysm? Emerging evidence of genetic variants related to TLR-4-mediated signaling pathway as risk …
2015
Abstract Sporadic thoracic aortic aneurysms (TAA) and dissections are one of the major causes of morbidity and mortality worldwide, especially in those older than 65 years. The presentation of TAA is varied and often silent. Thus, sporadic TAA detection is often fortuitous, with identification occurring during a routine physical examination or during an unrelated medical evaluation. Once suspected, confirmation by imaging clinical approaches is needed to allow the choose of the unique treatments for TAA, namely the surgery procedures, including elective surgery or endovascular repair before the onset of catastrophic and fatal complications, such as dissection or rupture. At present, there a…
Investing in Sports Facilities: The Italian Situation Toward an Olympic Perspective. Confidence Intervals for the Financial Analysis of Pools
2015
Given the current economic crisis, there is a lack of investments also for public sport facilities, which are vital to the urban quality of the city and the quality of life of its citizens. The situation is serious in Italy, especially after the failure of public policies for funding of major events (World Cup, 1990; Winter Olympics, 2006). Some recent laws (147/2013) have revived the sector with particular atten-tion to the medium size facilities but have neglected the small structures that represent the basic activities. In case of the latter, a convergence of objectives is needed between public administrations and private investors. Therefore, public au-thorities should think in terms of…
Physical Fitness Evaluation of School Children in Southern Italy: A Cross Sectional Evaluation
2018
The aim of this work was to evaluate the fitness levels of different physical components in schoolchildren in southern Italy and identify age-related effects of physical performance. One hundred and fifty-four schoolchildren with ages ranging between 6 and 10 years (age 8.1 ± 1.45 years; 33.70 ± 10.25 kg; 131.50 ± 13.60 cm) were recruited for the investigation. Each scholar underwent a fitness-test battery composed of five elements. A Hand-Grip Strength Test to assess the strength of the hand muscles, a Standing Broad Jump Test to assess lower body explosive strength, a Sit-Up Test to exhaustion to evaluate abdominal muscular endurance, a 4 × 10-m Shuttle Run Test to assess agility, and a 2…
La mobilità volontaria nel Pubblico Impiego: margini di discrezionalità dell'Amministrazione di destinazione
2022
Il contributo, a partire da una recente pronuncia del Tribunale di Catanzaro, affronta la questione dei margini di discrezionalità della pubblica amministrazione reclutante nei procedimenti di mobilità individuale volontaria ex art. 30 d.lgs. n. 165/2001, con specifico riferimento alla fase di valutazione delle competenze professionali dei candidati. Ciò offre l’occasione per soffermarsi sulla natura dell’istituto, anche alla luce dei più recenti approdi legislativi in materia.
Expert-based versus citation-based ranking of scholarly and scientific publication channels
2016
Abstract The Finnish publication channel quality ranking system was established in 2010. The system is expert-based, where separate panels decide and update the rankings of a set of publications channels allocated to them. The aggregated rankings have a notable role in the allocation of public resources into universities. The purpose of this article is to analyze this national ranking system. The analysis is mainly based on two publicly available databases containing the publication source information and the actual national publication activity information. Using citation-based indicators and other available information with association rule mining, decision trees, and confusion matrices, …
A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies
2011
The aim of the present work was to develop a new mathematical method for estimating the area under the curve (AUC) and its variability that could be applied in different preclinical experimental designs and amenable to be implemented in standard calculation worksheets. In order to assess the usefulness of the new approach, different experimental scenarios were studied and the results were compared with those obtained with commonly used software: WinNonlin® and Phoenix WinNonlin®. The results do not show statistical differences among the AUC values obtained by both procedures, but the new method appears to be a better estimator of the AUC standard error, measured as the coverage of 95% confi…
Ranking Scientific Journals Via Latent Class Models for Polytomous Item Response Data
2015
Summary We propose a model-based strategy for ranking scientific journals starting from a set of observed bibliometric indicators that represent imperfect measures of the unobserved ‘value’ of a journal. After discretizing the available indicators, we estimate an extended latent class model for polytomous item response data and use the estimated model to cluster journals. We illustrate our approach by using the data from the Italian research evaluation exercise that was carried out for the period 2004–2010, focusing on the set of journals that are considered relevant for the subarea statistics and financial mathematics. Using four bibliometric indicators (IF, IF5, AIS and the h-index), some…