Search results for " EVALUATION"
showing 10 items of 1458 documents
Randomized pilot study and qualitative evaluation of a clinical decision support system for brain tumour diagnosis based on SV 1H MRS: Evaluation as …
2014
The results of a randomized pilot study and qualitative evaluation of the clinical decision support system Curiam BT are reported. We evaluated the system's feasibility and potential value as a radiological information procedure complementary to magnetic resonance (MR) imaging to assist novice radiologists in diagnosing brain tumours using MR spectroscopy (1.5 and 3.0T). Fifty-five cases were analysed at three hospitals according to four non-exclusive diagnostic questions. Our results show that Curiam BT improved the diagnostic accuracy in all the four questions. Additionally, we discuss the findings of the users' feedback about the system, and the further work to optimize it for real envir…
Selection bias ed incentivi alle imprese nei programmi per lo sviluppo locale: una valutazione ex-post
2015
This paper focuses on the evaluation of an aid scheme included in a larger local development program realized in Italy during the 2000-2006 cycle of EU Structural Funds. It follows a previous analysis (Cusimano, Mazzola, 2014) on the ex-post evaluation of the effects of the aid schemes included in the so-called territorial integrated projects (tips) and aims at identifying the possible presence of selection bias in measuring the effectiveness of the policy. After running an empirical analysis based on several propensity score matching (psm) methods, we show that, at least partially, the positive results previously obtained may not be related to an effective success of the policy, but could …
Synthesis and biological evaluation of new indazole derivatives
2010
New N-methyl and N-ethyl substitutions in the indazole nucleus are reported by reacting 3-(2-aminobenzamido)indazole and the appropriate trimethyl/triethyl orthobenzoate. Single crystal X-ray analysis confirms the N-ethylation position for the 3-(1-ethyl-1H-indazol-3-yl)-2-phenylquinazolin-4(3H)-one derivative 3f. Compounds 11a-d and 3a-d were tested to evaluate their antimicrobial, their antiproliferative activity and their COX inhibitory activities showing scarce or moderately antiproliferative activity and some inhibitory activity against COX-1 and COX-2.
Novel 4-(3-phenylpropionamido), 4-(2-phenoxyacetamido) and 4-(cinnamamido) substituted benzamides bearing the pyrazole or indazole nucleus: synthesis…
2019
Based on some common structural features of known compounds interfering with p53 pathways and our previously synthesized benzamides, we synthesized new ethyl 5-(4-substituted benzamido)-1-phenyl-1H-pyrazole-4-carboxylates 26a-c, ethyl 5-(4-substituted benzamido)-1-(pyridin-2-yl)-1H-pyrazole-4-carboxylates 27a-c and N-(1H-indazol-6-yl)-4-substituted benzamides 31a,b bearing in the 4 position of the benzamido moiety the 2-phenylpropanamido or 2-phenoxyacetamido or cinnamamido groups. A preliminary test to evaluate the antiproliferative activity against human lung carcinoma H292 cells highlighted how compound 26c showed the best activity. This last was therefore selected for further studies wi…
Ex ante evaluation of cropping systems for weed-mediated pests and environmental benefits with simulation–based indicators
2016
SPEEAGESTADAGROSUP; International audience; Integrated crop protection tolerates residual weed floras if they are not harmful for crop production. These weeds can host harmful crop pests, among which parasitic plants such as broomrape (Phelipanche ramosa). They can also contribute to reduce soil erosion as well as nitrate and pesticide leaching. To evaluate these weed impacts of management practices ex ante, we developed indicators for the weed dynamics model FLORSYS (Colbach et al., 2014) and then used the model to predict weed-mediated broomrape risk and environmental benefits in cropping systems from five French regions. Materials and Methods FLORSYS is a virtual field on which cropping …
IANUS: Comparative analysis
2002
Jointly with the application of IANUS model in the selected facilities, in WP4 Ambiente Italia has to produce an evaluation and comparison between different facilities and core indicators. The aim of this paper is to show collected data, computed indicators and comparison facilities throuh suggested indicator evaluation system.
Measuring the Change Towards More Sustainable Mobility:MUV Impact Evaluation Approach
2019
Urban areas can be considered the ground for the challenges related to the UN&rsquo
Including functional usability features in a Model-Driven Development Method
2013
The Software Engineering (SE) community has historically focused on working with models to represent functionality and persistence, pushing interaction modelling into the background, which has been covered by the Human Computer Interaction (HCI) community. Recently, adequately modelling interaction, and specifically usability, is being considered as a key factor for success in user acceptance, making the integration of the SE and HCI communities more necessary. If we focus on the Model-Driven Development (MDD) paradigm, we notice that there is a lack of proposals to deal with usability features from the very first steps of software development process. In general, usability features are man…
Introducing Usability in a Conceptual Modeling-Based Software Development Process
2012
Usability plays an important role to satisfy users? needs. There are many recommendations in the HCI literature on how to improve software usability. Our research focuses on such recommendations that affect the system architecture rather than just the interface. However, improving software usability in aspects that affect architecture increases the analyst?s workload and development complexity. This paper proposes a solution based on model-driven development. We propose representing functional usability mechanisms abstractly by means of conceptual primitives. The analyst will use these primitives to incorporate functional usability features at the early stages of the development process. Fo…
Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives
2019
:In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities.:The present review with 411 references, in which we focused on the literatur…