Search results for " EVALUATION"
showing 10 items of 1458 documents
2-(2,6-Dihalophenyl)-3-(pyrimidin-2-yl)-1,3-thiazolidin-4-ones as non-nucleoside HIV-1 reverse transcriptase inhibitors.
2004
Several 1,3-thiazolidin-4-ones bearing a 2,6-dihalophenyl group at C-2 and a substituted pyrimidin-2-yl ring at the N-3 were synthesised and evaluated as anti-HIV agents. The results of the in vitro tests showed that some of them were highly effective inhibitors of human immunodeficiency virus type-1 (HIV-1) replication at 10–40 nM concentrations with minimal cytotoxicity. Structure–activity relationship studies revealed that the nature of the substituents at the 2 and 3 positions of the thiazolidinone nucleus had a significant impact on the in vitro anti-HIV activity of this class of potent antiretroviral agents. The compounds had significantly reduced activity against the characteristic N…
Development of Durum Wheat Breads Low in Sodium Using a Natural Low-Sodium Sea Salt
2020
Durum wheat is widespread in the Mediterranean area, mainly in southern Italy, where traditional durum wheat breadmaking is consolidated. Bread is often prepared by adding a lot of salt to the dough. However, evidence suggests that excessive salt in a diet is a disease risk factor. The aim of this work is to study the effect of a natural low-sodium sea salt (Saltwell®
MetAphAs Test. Metalanguage in Aphasia Assessment.
2018
Test MetAphAs: La evaluación del metalenguaje en la afasia (Rosell-Clari & Hernández-Sacristán, 2018) es una versión adaptada y abreviada de Rosell Clari & Hernández Sacristán, 2014). Esta prueba fue desarrollada inicialmente para evaluar las habilidades metalingüísticas naturales en personas con afasia (Hernández-Sacristán, Rosell-Clari, Serra-Alegre y Quiles-Climent, 2012). Las habilidades metalingüísticas naturales se refieren al uso del lenguaje que revela reflexividad (Hockett, 1960); es decir, la distancia perceptiva del hablante con respecto a su propio comportamiento verbal (Werner & Kaplan, 1978). Esta autoconciencia del lenguaje nos permite monitorear nuestros propios comportamien…
Leading agritourism facilities along Nearly Zero Energy paths: Proposal of an easy-to-use evaluation method
2020
The tourist sector, despite the present severe constraints imposed by the sanitary emergence, can be considered as an important component of almost all countries' economies. In Italy agriturism, in particular, has been experiences a continuously rising trend in recent years. Clearly, such great interest towards these businesses also calls for a deep attention by an energy point of view, in sight of an energy efficiency improvement, hence a lowering of the pressure that such facilities exert to the natural environment. On the other hand, the European Union has been engaged, for a long time, in awarding the tourist accommodations environmental excellence brands, like the EU Ecolabel. Unfortun…
Clinical evaluation of neodymium-iron-boron (Ne2Fe14B) rare earth magnets in the treatment of mid line diastemas
2015
Background: To evaluate the closure of midline diastema using the Neodymium-Iron-Boron magnets and to compare the treatment duration of midline diastemas with the use of magnets compared to regular orthodontic treatment. Materials and Methods: Thirty patients with age group 12 to 30 years with the midline diastema ranging from 0.5 to 3mm were selected. These patients were divided into two groups. Diastema closure in one group was accomplished by conventional method, in other group was done with Ne 2 Fe 14 B magnets. These magnets were fitted to the labial surfaces of the maxillary central incisors such a way that the opposite poles of the magnets face each other. At each appointment, study …
Minimally invasive interval debulking surgery in ovarian neoplasm (MISSION trial–NCT02324595): a feasibility study
2016
Background Laparoscopy has acquired an increasing role in the management of ovarian cancer. Laparoscopic cytoreduction could represent a new frontier for selected patients after neoadjuvant chemotherapy (NACT). Objective We sought to assess feasibility and early complication rate of minimally invasive (MI) interval debulking surgery (IDS) in stage III-IV epithelial ovarian cancer (EOC) patients after NACT. Study Design This is a phase II multicentric study in advanced EOC cases with clinical complete response after NACT, according to Gynecologic Cancer Intergroup and Response Evaluation Criteria In Solid Tumors criteria. Institutional review board approval was obtained and all patients sign…
Priority Levels Based Multi-hop Broadcasting Method for Vehicular Ad hoc Networks
2015
International audience; This paper deals with broadcasting problem in vehicular ad hoc networks (VANETs). This communication mode is commonly used for sending safety messages and traffic information. However, designing an efficient broadcasting protocol is hard to achieve since it has to take into account some parameters related to the network environment, for example, the network density, in order to avoid causing radio interferences. In this paper, we propose a novel Autonomic Dissemination Method (ADM) which delivers messages in accordance with given priority and density levels. The proposed approach is based on two steps: an offline optimization process and an adaptation to the network …
Controlled education of patients after stroke (ceops)-nurse-led multimodal and long-term interventional program involving a patient''s caregiver to o…
2018
Background Setting up a follow-up secondary prevention program after stroke is difficult due to motor and cognitive impairment, but necessary to prevent recurrence and improve patients’ quality of life. To involve a referent nurse and a caregiver from the patient’s social circle in nurse-led multimodal and long-term management of risk factors after stroke could be an advantage due to their easier access to the patient and family. The aim of this study is to compare the benefit of optimized follow up by nursing personnel from the vascular neurology department including therapeutic follow up, and an interventional program directed to the patient and a caregiving member of their social circle,…
Halothane inhibits endothelium-dependent relaxation elicited by acetylcholine in human isolated pulmonary arteries.
1997
This study examined whether a clinically relevant concentration of the volatile anaesthetic halothane modifies the endothelium-dependent relaxation produced by acetylcholine (3 nM-10 microM), histamine (1 pM-0.1 microM) and anti-human immunoglobulin E (1:1000) in human isolated pulmonary arteries submaximally precontracted with noradrenaline. An inhibitor of nitric oxide formation, N(G)-nitro-L-arginine (100 microM), attenuated acetylcholine-induced relaxation but failed to inhibit histamine- and anti-human immunoglobulin E-induced relaxation. Indomethacin (2.8 microM, a cyclooxygenase inhibitor) preferentially reduced the relaxation to histamine and anti-human IgE. Halothane (2%) significa…
Seismic prevention and rehabilitation of nonstructural elements. Application experiences of nonstructural pre-seismic evaluation
2012
Topics concerning nonstructural seismic prevention and rehabilitation take their place in the main context of buildings safety in order to explore some aspects of performance of those technical elements. They have become very topical in Italy in the last decade since the repetition of seismic events has made vulnerability and its implications obvious not only in terms of safety risk. This paper reports briefly about author research experiences in this topic and more detail an experience as a component of research team, organizer and tutor in the activities of an international cooperation project between University of Palermo and University of California-Berkeley. After a short introduction …