Search results for " Elimi"
showing 10 items of 91 documents
Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring
2016
The first general catalytic method for the, so far elusive, enantioselective Friedel−Crafts functionalization of indoles in the carbocyclic ring is presented. This transformation contrasts with the usual tendency of these heterocycles to react at the azole ring. For this purpose, the four regioisomeric hydroxy carbocyclic-substituted indoles were reacted with several isatinderived ketimines, using a Cinchona alkaloid-based squaramide, in a low 0.5−5 mol % catalyst loading, as a bifunctional catalyst. This methodology allows the functionalization of indoles in every position of the carbocyclic ring in a regio- and enantioselective fashion, by switching only the position of the hydroxy group …
Implementare le politiche sanitarie a livello regionale per l'eliminazione dell'epatite C ai tempi del COVID-19
2022
Viral hepatitis C is an important public health problem and its elimination by 2030, defined by the World Health Organization, is an ambitious goal. The chance of free screening for HCV infection represents an important achievement that requires a successful State-Regions coordination and an effective regional organisation, that guarantees an interdisciplinary course between local and specialized healthcare. A structured communication program to increase the sensitivity of target populations as well as health professionals is the key for success. The implementation of the proactive screening, defined by the Milleproroghe Law, is crucial because it will define the tracks for the whole HCV co…
Protección de las víctimas de violencia doméstica: Estudio del Derecho internacional, europeo y comparado de las legislaciones española y alemana
2020
El presente trabajo tiene por objeto analizar producción normativa tanto internacional como europea más relevante en materia de protección de las víctimas de violencia género, en general, y violencia doméstica, en particular. Dicho estudio se lleva a cabo al hilo de la producción legislativa así como procedimientos de control y cooperación internacionales y europeos en la materia. En primer lugar, se analiza la normativa internacional que emana de Naciones Unidas (Convención sobre la Eliminación de Todas las Formas de Discriminación contra la Mujer - CEDAW); en segundo lugar, la del Consejo de Europa (Convenio sobre prevención y lucha contra la violencia contra las mujeres y la violencia do…
Etherification of Functionalized Phenols with Chloroheteroarenes at Low Palladium Loading: Theoretical Assessment of the Role of Triphosphane Ligands…
2011
The present study highlights the potential of robust tridentate ferrocenylphosphanes with controlled conformation as catalytic auxiliaries in CO bond formation reactions. Air-stable palladium triphosphane systems are efficient for selective heteroaryl ether synthesis by using as little as 0.2 mol% of catalyst. These findings represent an economically attractive and clean etherification of functionalized phenols, electron-rich, electron-poor and para-, meta- or ortho-substituted substrates, with heteroaryl chlorides, including pyridines, hydroxylated pyridine, pyrimidines and thiazole. The etherification tolerates very important functions in various positions, such as cyano, methoxy, amino, …
Reazione di eliminazione di Kemp: una sonda per lo studio delle proprietà microscopiche di liquidi ionici
Disposition of ciprofloxacin following intravenous administration in dogs
1994
The pharmacokinetics of ciprofloxacin (CIP) following intravenous administration in dogs have been investigated. The drug was administered at three doses (2.5, 5 and 10 mg/kg body weight) and was assayed in biological fluid samples (plasma and urine) by an HPLC method. The plasma concentration-time curves were best described by a two-compartment open pharmacokinetic model. The drug was widely distributed (Vd(area) almost 3 l/kg), being distributed in the dog more rapidly than in other species (t1/2(lambda 1) 3 min approximately). The elimination half-life (t1/2 lambda 2) was 129-180 min which is similar to values obtained in other species. The unchanged drug eliminated in urine was less tha…
A new branch-and-price algorithm for the traveling tournament problem
2010
Abstract The traveling tournament problem ( ttp ) consists of finding a distance-minimal double round-robin tournament where the number of consecutive breaks is bounded. For solving the problem exactly, we propose a new branch-and-price approach. The starting point is a new compact formulation for the ttp . The corresponding extensive formulation resulting from a Dantzig-Wolfe decomposition is identical to one given by Easton, K., Nemhauser, G., Trick, M., 2003. Solving the traveling tournament problem: a combined interger programming and constraint programming approach. In: Burke, E., De Causmaecker, P. (Eds.), Practice and Theory of Automated Timetabling IV, Volume 2740 of Lecture Notes i…
What is the Best Method of Matrix Adjustment? A Formal Answer by a Return to the World of Vectors
2003
The principle of matrix adjustment methods consists into finding what is the matrix which is the closest to an initial matrix but with respect of the column and row sum totals of a second matrix. In order to help deciding which matrix-adjustment method is the better, the article returns to the simpler problem of vector adjustment then back to matrices. The information-lost minimization (biproportional methods and RAS) leads to a multiplicative form and generalize the linear model. On the other hand, the distance minimization which leads to an additive form tends to distort the data by giving a result asymptotically independent to the initial matrix. The result allows concluding non-ambiguou…
Cyclometalated Au(III) Complexes for Cysteine Arylation in Zinc Finger Protein Domains: Towards Controlled Reductive Elimination
2019
With the aim of exploiting the use of organometallic species for the efficient modification of proteins through C-atom transfer, the gold-mediated cysteine arylation through a reductive elimination process occurring from the reaction of cyclometalated AuIII C^N complexes with a zinc finger peptide (Cys2His2 type) is here reported. Among the four selected AuIII cyclometalated compounds, the [Au(CCON)Cl2] complex featuring the 2-benzoylpyridine (CCON) scaffold was identified as the most prone to reductive elimination and Cys arylation in buffered aqueous solution (pH 7.4) at 37 °C by high-resolution LC electrospray ionization mass spectrometry. DFT and quantum mechanics/molecular mechanics (Q…
Recursive Selective Harmonic Elimination for Multilevel Inverters: Mathematical Formulation and Experimental Validation
2023
A recursive method that eliminates +1 harmonics and their respective multiples from the output voltage of a cascaded H-bridge multilevel inverters with = 2 dc sources ( = 1, 2, 3,...) is proposed. It solves 2×2 linear systems with not singular matrices and always gives an exact solution with very low computational effort. Simulated results in three-phase five, nine, seventeen and thirty three level CHB inverters, and experimental results in five-level inverter demonstrate the validity of the method.