Search results for " Enti"

showing 10 items of 157 documents

Rapid sequencing and genetic analysis of the pandemic (H1N1)V influenza virus circulating in pigs in Italy

2011

will continue to pose challenge to public health and scientifi c community. General concern exists about possible mutation or reassortment between the H1N1pdm and infl uenza viruses circulating in human and animal, giving rise to more transmissible or pathogenic viruses. Emergence of resistance during antiviral treatment is a wellrecognised phenomenon in infl uenza viruses; surveillance for emergence of resistant viruses is of importance for monitoring this potential public health problem in the context of the H1N1 pandemic. Thus preparedness to identify new strains would require fast sequencing of the full genome of virus. Here we present an optimised workfl ow for rapid sequencing of the …

Influenza viruses H1N1 pandemic rapid sequencing of the entire genome genetic surveillance activity pigs
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L'istituzione dei Liberi consorzi di Comuni e delle Città metropolitane in Sicilia, ovvero della specialità vagheggiata

2018

L'istituzione dei liberi Consorzi di Comuni e delle città metropolitane ha impegnato l'Assemblea regionale nella precedente legislatura, senza che sia stata prodotta una disciplina organica, in grado di dare attuazione all'art. 15 dello Statuto tenendo conto anche dei vincoli alla potestà legislativa esclusiva della Regione. Di qui le pronunce della Corte costituzionale. Il saggio esamina la relativa problematica.

Liberi consorzi Città metropolitane Statuto siciliano Potestà legislativa esclusiva limiti costituzionali Corte costituzionale Legge Delrio area vasta ordinamento degli Enti LocaliSettore IUS/08 - Diritto Costituzionale
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How an idea germinates into a projext or the intransitive resultative construction with Entity-Specific change-of-state verbs

2014

[EN] This study discusses how seven of Levin’s (1993) entity-specific change-of-state verbs (i.e. bloom, blossom, flower, germinate, sprout, swell, and blister) are subsumed into the intransitive resultative construction by highlighting and making use of the external and internal constraints proposed by the Lexical Constructional Model (LCM; Ruiz de Mendoza and Mairal 2007). External constraints refer to cognitive mechanisms such as high-level metaphor and/or metonymy whereas internal constraints are concerned with the encyclopedic and event structure makeup of verbs. The Internal Variable Conditioning constraint is at work when the information encapsulated by a predicate determines the cho…

Linguistics and LanguageMetonymyMetaphorKeywords: entity-specific change-of-state verbsmedia_common.quotation_subjectVerbLanguage and LinguisticsPredicate (grammar)Linguisticsthe Internal Variable Conditioning constraint.lcsh:Philology. LinguisticsIntransitive resultative constructionEvent structureThe Internal Variable Conditioning constraintlcsh:P1-1091ResultativeInternal variableEntity-specific change-of-state verbsLexical Constructional ModelExternal and internal constraintsmedia_commonMathematicsLlenguatge i llengües
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Comparing Long-Acting Antipsychotic Discontinuation Rates Under Ordinary Clinical Circumstances: A Survival Analysis from an Observational, Pragmatic…

2021

Background Recent guidelines suggested a wider use of long-acting injectable antipsychotics (LAI) than previously, but naturalistic data on the consequences of LAI use in terms of discontinuation rates and associated factors are still sparse, making it hard for clinicians to be informed on plausible treatment courses. Objective Our objective was to assess, under real-world clinical circumstances, LAI discontinuation rates over a period of 12 months after a first prescription, reasons for discontinuation, and associated factors. Methods The STAR Network ‘Depot Study’ was a naturalistic, multicentre, observational prospective study that enrolled subjects initiating a LAI without restrictions …

MalePediatricsrespectively)0302 clinical medicineDelayed-Action PreparationBrief Psychiatric Rating ScalePharmacology (medical)he STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in ItalyOriginal Research ArticleProspective StudiesProspective cohort studytreatmentMental DisordersHazard ratiowhereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5%Psychiatric Status Rating ScaleMiddle Agedside efectsPsychiatry and Mental healthItalyMental DisorderFemalehe STAR Network ‘Depot Study’ prospectively followed 394 subjects initiating treatment with long-acting injections (LAIs) of antipsychotics under naturalistic conditions for 12 months. LAI discontinuation was frequent in everyday clinical practice in Italy occurring in almost 40% of the entire sample; side efects participant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4% respectively) whereas more than half of participants initiating risperidone LAI and olanzapine LAI discontinued during the 12 months of follow-up (51.4 and 62.5% respectively). In multivariate analysis being prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation risk.HumanAntipsychotic Agentsmedicine.drugPsychopathologyAdultmedicine.medical_specialtyDiscontinuationFollow-Up StudieMedication Adherence03 medical and health sciencesmedicineHumansPaliperidoneAdverse effectSettore MED/25 - Psichiatriadiscontinuation ratesPsychiatric Status Rating Scalesrespectively). In multivariate analysisbusiness.industryLong-Acting Antipsychoticlong-acting injectable antipsychoticsSurvival AnalysisConfidence intervalparticipant refusal to continue LAIs and LAIs no longer being required were the most frequently reported reasons for discontinuation. Paliperidone LAI and aripiprazole LAI were the least discontinued medications (33.9 and 35.4%030227 psychiatryDiscontinuationProspective StudieAntipsychotic Agentoccurring in almost 40% of the entire sampleDelayed-Action PreparationsNeurology (clinical)business030217 neurology & neurosurgerybeing prescribed olanzapine LAI and poor medication adherence at baseline were signifcantly associated with higher discontinuation riskFollow-Up Studies
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A strange pneumonia

2013

We report the case of a 62-year-old man with non-ST elevation myocardial infarction complicated by partial rupture of the antero-lateral papillary muscle in which severe mitral regurgitation with lateralized direction towards the right pulmonary veins gave unilateral pulmonary oedema, resembling an acute pneumonia.Unilateral pulmonary oedema is a rare entity, more frequently appearing as opacity of the right lung and always associated with severe mitral regurgitation. It is very important to suspect and promptly recognize unilateral pulmonary oedema because initial misdiagnosis leads to a delay in the initiation of appropriate treatment and to an increased risk of mortality.

Malemedicine.medical_specialtyPulmonary Edema030204 cardiovascular system & hematologyPulmonary oedemaDiagnosis Differential03 medical and health sciences0302 clinical medicineInternal medicinemedicineHumanspneumoniaMyocardial infarctionNon-ST Elevated Myocardial InfarctionPapillary muscleMitral regurgitationLungbusiness.industryRare entityGeneral MedicineMiddle Agedmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareMyocardial infarctionPneumoniamedicine.anatomical_structureIncreased risk030228 respiratory systemCardiologyCardiology and Cardiovascular MedicinebusinessJournal of Cardiovascular Medicine
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L'abolizione delle Province in Sicilia: resoconto semiserio di un rivoluzione in progress

2014

Mentre a livello nazionale era in corso il dibattito sul destino delle Province la Regione Sicilia ha inteso anticipare i tempi procedendo all'abolizione delle proprie Province e la loro sostituzione da parte dei Liberi Consorzi comunali e delle Città metropolitane. Tuttavia l'esatto dimensionamento funzionale dei due nuovi enti resta affidato alla futura legislazione così come incerte appaiono le modalità per la riorganizzazione dei servizi del personale e delle risorse. Il dubbio che tutto rimanga come prima e che la rivoluzione si concreti nella pratica nel mantenimento dell'esistente seppur rivisto sul piano della rappresentatività politica appare molto più che fondato.
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The Italian regulation of public procurement contracts and the prevention of money laundering in pandemic times

2023

This paper aims to explain the peculiarities of Italian public procurement contracts and the remedies provided to prevent money laundering and other criminal activities related to the unlawful interference in these relationships between private economic operators and public entities. The analysis starts from the examination of public subjects, their role and mode of action according to the Italian legal system, with particular attention to the discipline of public procurement contracts and the connected money laundering risks. Due to the peculiarity of the economical relationships involved, of the parties and of the subject, these contracts, are mostly regulated by a Decree, called Code of …

Money launderingPublic procurement contractF.I.U.Public entitiereport obligation
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Teorie implicite sull’intelligenza e motivazione intrinseca

2016

In questo articolo si mette a fuoco come per stimolare l’apprendimento e sviluppare l’autonomia degli alunni sia fondamentale, fin dalla scuola primaria, riconoscere l’importanza delle teorie implicite sull’intelligenza e il ruolo essenziale che ricoprono nello sviluppo della motivazione intrinseca. Un fattore che influenza la motivazione e, di conseguenza, il successo scolastico è il tipo di concezione dell’intelligenza posseduto dagli alunni che sviluppano approcci differenti all’apprendimento in relazione ad essa. Il possesso da parte di un alunno di teorie implicite entitarie o incrementali è cruciale nell’adeguata o nella mancata elaborazione di successi e fallimenti, nonché predittivo…

Motivazione intrinseca teoria entitaria teoria incrementaleSettore M-PED/03 - Didattica E Pedagogia Speciale
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Rationale and design of the CRAFT (Continuous ReAssessment with Flexible ExTension in Rare Malignancies) multicenter phase II trial.

2021

Background Approvals of cancer therapeutics are primarily disease entity specific. Current molecular diagnostic approaches frequently identify actionable alterations in rare cancers or rare subtypes of common cancers for which the corresponding treatments are not approved and unavailable within clinical trials due to entity-related eligibility criteria. Access may be negotiated with health insurances. However, approval rates vary, and critical information required for a scientific evaluation of treatment-associated risks and benefits is not systematically collected. Thus clinical trials with optimized patient selection and comprehensive molecular characterization are essential for translati…

OncologyAdultCancer Researchmedicine.medical_specialtymedicine.medical_treatmentLocally advancedAntineoplastic AgentsPhosphatidylinositol 3-KinasesClinical Trials Phase II as TopicInternal medicineNeoplasmsClinical endpointMedicineHumansMulticenter Studies as TopicRisks and benefitsOriginal ResearchDisease entitybusiness.industrytarget therapyCancerImmunotherapymedicine.diseaseProgression-Free SurvivalClinical trialERBB2 AmplificationOncologyprecision oncologyMutationimmunotherapyclinical trial in progressbusinessESMO open
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ER-/PgR+ breast cancer is a separate entity characterized by distinct phenotype: Comprehensive reevaluation of cases from Polish and Hungarian center…

2020

e12554 Background: ER negative (-)/PgR positive (+) breast cancer (BC) is very uncommon and questioned by many experts. We comprehensively reevaluated ER-/PgR+ BCs in the large cohort from Polish and Hungarian centers. Methods: FFPE blocks from 105 ER-/PgR+ tumors (45 breast biopsies and 64 post-operative samples from tumors not exposed to systemic therapy) were collected from 10 Polish and 3 Hungarian centers. In 60 cases available original slides with ER/PgR staining underwent reevaluation by 3 pathologists (MK, RP, WB) for ER and PgR expression by ASCO/CAP criteria. Subsequently, all samples were stained with 3 antibodies against ER (Dako monoclonal (MC) mouse anti-ERα, clone 1D5; Dako …

Oncologyendocrine systemCancer Researchmedicine.medical_specialtybusiness.industryPGR Positivemedicine.diseaseER NegativePhenotypeLarge cohortBreast cancerOncologyInternal medicineMedicineskin and connective tissue diseasesbusinessSeparate legal entityJournal of Clinical Oncology
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