Search results for " Experimental"
showing 10 items of 3530 documents
Lovastatin attenuates ionizing radiation-induced normal tissue damage in vivo.
2009
Abstract Background and purpose HMG-CoA-reductase inhibitors (statins) are widely used lipid-lowering drugs. Moreover, they have pleiotropic effects on cellular stress responses, proliferation and apoptosis in vitro . Here, we investigated whether lovastatin attenuates acute and subchronic ionizing radiation-induced normal tissue toxicity in vivo . Materials and methods Four hours to 24h after total body irradiation (6Gy) of Balb/c mice, acute pro-inflammatory and pro-fibrotic responses were analyzed. To comprise subchronic radiation toxicity, mice were irradiated twice with 2.5Gy and analyses were performed 3weeks after the first radiation treatment. Molecular markers of inflammation and f…
TRAIL-R4 promotes tumor growth and resistance to apoptosis in cervical carcinoma HeLa cells through AKT.
2011
International audience; BACKGROUND: TRAIL/Apo2L is a pro-apoptotic ligand of the TNF family that engages the apoptotic machinery through two pro-apoptotic receptors, TRAIL-R1 and TRAIL-R2. This cell death program is tightly controlled by two antagonistic receptors, TRAIL-R3 and TRAIL-R4, both devoid of a functional death domain, an intracellular region of the receptor, required for the recruitment and the activation of initiator caspases. Upon TRAIL-binding, TRAIL-R4 forms a heteromeric complex with the agonistic receptor TRAIL-R2 leading to reduced caspase-8 activation and apoptosis. METHODOLOGY/PRINCIPAL FINDINGS: We provide evidence that TRAIL-R4 can also exhibit, in a ligand independent…
Beyond free will : The embodied emergence of conscious agency
2019
Is it possible to reconcile the concept of conscious agency with the view that humans are biological creatures subject to material causality? The problem of conscious agency is complicated by the tendency to attribute autonomous powers of control to conscious processes. In this paper, we offer an embodied process model of conscious agency. We begin with the concept of embodied emergence – the idea that psychological processes are higher-order biological processes, albeit ones that exhibit emergent properties. Although consciousness, experience, and representation are emergent properties of higher-order biological organisms, the capacity for hierarchical regulation is a property of all livin…
The Attention Schema Theory: A Foundation for Engineering Artificial Consciousness
2017
The purpose of the attention schema theory is to explain how an information-processing device, the brain, arrives at the claim that it possesses a non-physical, subjective awareness, and assigns a high degree of certainty to that extraordinary claim. The theory does not address how the brain might actually possess a non-physical essence. It is not a theory that deals in the non-physical. It is about the computations that cause a machine to make a claim and to assign a high degree of certainty to the claim. The theory is offered as a possible starting point for building artificial consciousness. Given current technology, it should be possible to build a machine that contains a rich internal …
The conceptualisation of austerity in the Portuguese, Spanish and Irish press
2017
The aim of this chapter is to analyse the conceptualisation of austerity in three different European cultures by identifying metaphorical expressions used in one representative newspaper of the Portuguese, the Spanish and the Irish press between 2011 and 2012. The metaphors were identified by searching for three keywords from the field of economy and politics (austeridade-austeridad-austerity, corte-recorte-cut and divida-deuda-debt) and were then classified according to the type of schema they instantiate, namely, propositional schema, image schema or event schema. Assuming the general framework of Cultural Linguistics and corpus-based and discourse-based approaches to conceptual metaphor,…
2019
Previous research indicates that programmes employing Hellison’s Teaching Personal and Social Responsibility (TPSR) model in physical activity have had a positive impact on youth development by inc...
El Dr. Simarro y la Psicología Científica en España
1987
Se presentan las grandes líneas maestras de la Psicología del Dr. Simarro, una concepción reconstruida a partir de los muy pocos textos científicos escritos por Simarro. Se trata de una Psicología asociacionista, muy influída por Charcot, que reivindica la actualidad y validez de la teoría asociacionista de Luis Vives, y que se interesa por una conciliación entre los desarrollos descriptivos llevados a cabo por los psicólogos ingleses y los experimentales de las escuelas alemanas. Simarro quería dar a la Psicología una sólida base evolucionista y fisiológica y para ello aprovechó sus amplios conocimientos biológicos y clínicos. Sin embargo, no logró institucionalizar adecuadamente, en la Un…
P-Value, Confidence Intervals, and Statistical Inference: A New Dataset of Misinterpretation
2017
Statistical inference is essential for science since the twentieth century (Salsburg, 2001). Since it's introduction into science, the null hypothesis significance testing (NHST), in which the P-value serves as the index of “statistically significant,” is the most widely used statistical method in psychology (Sterling et al., 1995; Cumming et al., 2007), as well as other fields (Wasserstein and Lazar, 2016). However, surveys consistently showed that researchers in psychology may not able to interpret P-value and related statistical procedures correctly (Oakes, 1986; Haller and Krauss, 2002; Hoekstra et al., 2014; Badenes-Ribera et al., 2016). Even worse, these misinterpretations of P-value …
Las estrategias de afrontamiento: relación con la integridad y la desesperación en adultos mayores
2020
Resumen Antecedentes y objetivo Adaptarse con exito al envejecimiento facilita la consecucion de la integridad. Las estrategias de afrontamiento son clave en este proceso de adaptacion, y dependiendo del tipo de estrategias que se apliquen, se puede conseguir la integridad o bien caer en la desesperacion. El objetivo de este estudio fue analizar la relacion entre las estrategias de afrontamiento y la edad con las dimensiones de integridad y desesperacion en una muestra de adultos mayores. Materiales y metodos Se evaluaron las estrategias de afrontamiento, la integridad y la desesperacion en una muestra de 325 adultos mayores sanos. Se realizaron regresiones lineales multiples para estudiar …