Search results for " Experimental"
showing 10 items of 3530 documents
Efecto pantalla y efecto Sísifo: dos fenómenos didácticos en la resolución de problemas por transferencia analógica
2014
Se presenta un estudio cualitativo, basado en entrevistas semi-estructuradas, de 2 casos que muestran dos fenomenos didacticos de interes en la resolucion de problemas por transferencia analogica. El primero muestra un ‘efecto pantalla’, en el cual el sujeto no puede acceder a la estructura de los problemas a partir de los enunciados. En el segundo caso, el sujeto no logra alcanzar un estado estable de comprension, a pesar de su avance, y por tanto acaba por retroceder a un estado de ausencia de conflicto cognitivo, pero indeseado desde el punto de vista didactico (‘efecto Sisifo’). Se discuten las posibles implicaciones didacticas de estos casos.
A novel microtubule de-stabilizing complementarity-determining region C36L1 peptide displays antitumor activity against melanoma in vitro and in vivo
2015
AbstractShort peptide sequences from complementarity-determining regions (CDRs) of different immunoglobulins may exert anti-infective, immunomodulatory and antitumor activities regardless of the specificity of the original monoclonal antibody (mAb). In this sense, they resemble early molecules of innate immunity. C36L1 was identified as a bioactive light-chain CDR1 peptide by screening 19 conserved CDR sequences targeting murine B16F10-Nex2 melanoma. The 17-amino acid peptide is readily taken up by melanoma cells and acts on microtubules causing depolymerization, stress of the endoplasmic reticulum and intrinsic apoptosis. At low concentrations, C36L1 inhibited migration, invasion and proli…
Nascita e sviluppo della ricerca empirica in campo didattico in Italia
2015
Si ritiene che la ricerca didattica in Italia si sia riavviata intorno al 1950 per il contatto con le scuole statunitensi, per la diffusione delle opere di Dewey e per la nascita dell’Istituto Superiore di Pedagogia della congregazione salesiana. Si ricostruisce il periodo pioneristico della ricerca empirica in campo didattico con il contributo di Calonghi e Visalberghi. Si segnalano alcuni eventi significativi che, intorno alla metà degli anni Settanta, contribuirono all’affermazione della Didattica come scienza dell’insegnamento-apprendimento. Si indicano le principali linee di ricerca empirica in Didattica presenti nell’attuale panorama scientifico italiano.
Rilkean Memories and the Self of a Robot
2019
This paper discusses the concept of Rilkean memories, recently introduced by Mark Rowlands, to analyze the complex intermix of hardware and software related to the self of a robot. The Rilkean memory of an event is related to the trace of that episode left in the body of the individual. It transforms the act of remembering into behavioral and bodily dispositions, thus generating the peculiar behavioral style of the individual, which is at the basis of her autobiographical self. In the case of long-life operating robots, a similar process occurs: the software of the robot has to cope with the changes that happened in the body of the robot because of damaging events in its operational life. T…
Positron production using a 9 MeV electron linac for the GBAR experiment
2020
For the GBAR (Gravitational Behaviour of Antihydrogen at Rest) experiment at CERN's Antiproton Decelerator (AD) facility we have constructed a source of slow positrons, which uses a low-energy electron linear accelerator (linac). The driver linac produces electrons of 9 MeV kinetic energy that create positrons from bremsstrahlung-induced pair production. Staying below 10 MeV ensures no persistent radioactive activation in the target zone and that the radiation level outside the biological shield is safe for public access. An annealed tungsten-mesh assembly placed directly behind the target acts as a positron moderator. The system produces $5\times10^7$ slow positrons per second, a performan…
The Joint Distribution Criterion and the Distance Tests for Selective Probabilistic Causality
2010
A general definition and a criterion (a necessary and sufficient condition) are formulated for an arbitrary set of external factors to selectively influence a corresponding set of random entities (generalized random variables, with values in arbitrary observation spaces), jointly distributed at every treatment (a set of factor values containing precisely one value of each factor). The random entities are selectively influenced by the corresponding factors if and only if the following condition, called the joint distribution criterion, is satisfied : there is a jointly distributed set of random entities, one entity for every value of every factor, such that every subset of this set that corr…
Influence of a Thiolate Chemical Layer on GaAs (100) Biofunctionalization: An Original Approach Coupling Atomic Force Microscopy and Mass Spectrometr…
2013
International audience; Widely used in microelectronics and optoelectronics; Gallium Arsenide (GaAs) is a III-V crystal with several interesting properties for microsystem and biosensor applications. Among these; its piezoelectric properties and the ability to directly biofunctionalize the bare surface, offer an opportunity to combine a highly sensitive transducer with a specific bio-interface; which are the two essential parts of a biosensor. To optimize the biorecognition part; it is necessary to control protein coverage and the binding affinity of the protein layer on the GaAs surface. In this paper; we investigate the potential of a specific chemical interface composed of thiolate molec…
Prosociality and life satisfaction: A daily-diary investigation among Spanish university students
2018
Abstract With a diary study, we tested the positive effect of prosociality on life satisfaction. Fifty-six Spanish undergraduate students (45 females; Mage = 21.08 years) rated their life satisfaction, prosociality, self-esteem, and physical appearance for 5 consecutive days. Multilevel results indicated that within-individual positive deviations in prosociality (i.e., behaving more prosocial than usual) were uniquely and significantly associated with higher life satisfaction on that specific day. Students' self-esteem, physical appearance, and positive daily events were also predictive of life satisfaction. Exploratory analyses revealed that the positive effect of prosociality on life sati…
The myth of cognitive agency: subpersonal thinking as a cyclically recurring loss of mental autonomy
2018
This metatheoretical paper investigates mind wandering from the perspective of philosophy of mind. It has two central claims. The first is that, on a conceptual level, mind wandering can be fruitfully described as a specific form of mental autonomy loss. The second is that, given empirical constraints, most of what we call “conscious thought” is better analyzed as a subpersonal process that more often than not lacks crucial properties traditionally taken to be the hallmark of personal-level cognition - such as mental agency, explicit, consciously experienced goal-directedness, or availability for veto control. I claim that for roughly two thirds of our conscious life-time we do not possess …
Habit and physical activity: Theoretical advances, practical implications, and agenda for future research
2019
Abstract Objective Understanding habits may inform intervention development aimed at promoting physical activity maintenance for long-term health. In the present article, I review theory and research on habits applied to physical activity. I provide an overview of contemporary conceptualizations of habit and habit theory; address whether or not physical activity can be habitual; review perspectives on how physical activity habits develop; summarize research on effects of physical activity habits; identify intervention strategies effective in promoting physical activity habits; and propose an agenda for future research on physical activity habits. Design and Methods Conceptual and narrative …