Search results for " Experimental"
showing 10 items of 3530 documents
Thermo-Mechanical Behaviour of Flax-Fibre Reinforced Epoxy Laminates for Industrial Applications
2015
The present work describes the experimental mechanical characterisation of a natural flax fibre reinforced epoxy polymer composite. A commercial plain woven quasi-unidirectional flax fabric with spun-twisted yarns is employed in particular, as well as unidirectional composite panels manufactured with three techniques: hand-lay-up, vacuum bagging and resin infusion. The stiffness and strength behaviours are investigated under both monotonic and low-cycle fatigue loadings. The analysed material has, in particular, shown a typical bilinear behaviour under pure traction, with a knee yield point occurring at a rather low stress value, after which the material tensile stiffness is significantly r…
Desarrollo de modelos experimentales de LGMDD2 y rastreo de fármacos
2023
La distrofia muscular de cinturas tipo D2 (Limb-girdle muscular dystrophy type D2, LGMDD2) es una enfermedad genética ultra rara para la cual no existe tratamiento. Las principales características clínicas de la LGMDD2 son la debilidad y degeneración muscular progresiva que afecta a las cinturas pélvica y escapular de forma predominante. En 2013 se identificó la LGMDD2 como una miopatía autosómica dominante causada por una mutación en el gen de la transportina 3 (TNPO3), dando como resultado una proteína mutante con una extensión de 15 aminoácidos adicionales: TNPO3mut. TNPO3 es una β-importina responsable de la importación nuclear de proteínas ricas en serina/arginina (proteínas SR), invol…
Transferencia génica hepática hidrodinámica en modelos de cerdo in vivo y segmento humano ex vivo
2015
Introducción: La terapia génica es una estrategia terapéutica que pretende utilizar ácidos nucleicos como medicamentos para el tratamiento temporal o permanente de patologías hereditarias o adquiridas. En base al vehículo utilizado para entregar el gen, podemos clasificar la terapia génica en dos grupos: la terapia génica viral (vectores virales) y la terapia génica no viral (vectores no virales o ADN desnudo). La terapia no viral resulta menos eficiente pero más segura. La hidrofección (transferencia génica hidrodinámica) ha mostrado un gran potencial, con resultados terapéuticos en ratón. Sin embargo, cuando la hidrofección se ha trasladado a animales de mayor tamaño, el procedimiento ha …
Problem Transformation Methods with Distance-Based Learning for Multi-Target Regression
2020
Multi-target regression is a special subset of supervised machine learning problems. Problem transformation methods are used in the field to improve the performance of basic methods. The purpose of this article is to test the use of recently popularized distance-based methods, the minimal learning machine (MLM) and the extreme minimal learning machine (EMLM), in problem transformation. The main advantage of the full data variants of these methods is the lack of any meta-parameter. The experimental results for the MLM and EMLM show promising potential, emphasizing the utility of the problem transformation especially with the EMLM. peerReviewed
Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications
2020
Carbon nanodots (CDs) have recently attracted attention in the field of nanomedicine because of the biocompatibility, cost-effective nature, high specific surface, good near infrared (NIR) photothermal conversion into heat and tunable fluorescence properties, which have paved the way toward incorporating use of CDs into innovative anticancer theranostic platforms. However, a reliable synthesis of CDs with established and controlled physiochemical proprieties is precluded owing to the lack of full manipulation of thermodynamic parameters during the synthesis, thus limiting their use in real world medical applications. Herein, we developed a robust solvothermal protocol which allow fine contr…
Single chords convey distinct emotional qualities to both naïve and expert listeners.
2014
Previous research on music and emotions has been able to pinpoint many structural features conveying emotions. Empirical research on vertical harmony’s emotional qualities, however, has been rare. The main studies in harmony and emotions usually concern the horizontal aspects of harmony, ignoring emotional qualities of chords as such. An empirical experiment was conducted where participants ( N = 269) evaluated pre-chosen chords on a 9-item scale of given emotional dimensions. 14 different chords (major, minor, diminished, augmented triads and dominant, major and minor seventh chords with inversions) were played with two distinct timbres (piano and strings). The results suggest significant…
La imprenta en México: cuestiones terminológicas y tipología de los primeros impresos americanos
2020
espanolLa cultura impresa mexicana tiene su origen en los albores del siglo XVI con la instalacion de la primera prensa tipografica en el continente y la fabricacion de las primeras ediciones impresas en el continente. Esta primitiva produccion, y cada uno de los ejemplares que la integraba, fechados entre 1539 y 1634, recibieron el nombre de incunables americanos a semejanza de los primeros libros impresos en Europa entre la creacion de la imprenta y el 1 de enero de 1501. Sin embargo, poco tenian que ver los iniciales americanos con los primeros textos impresos en Europa hacia mas de cincuenta anos, por lo que la utilizacion del termino incunable resulto desde un primer momento confusa. E…
Dynamic Usage-based Principles in the Development of L2 Finnish Evaluative Constructions
2021
Abstract This study investigates the formal verbalizations of evaluation used by four beginning L2 learners of Finnish from a dynamic usage-based perspective. Longitudinal data collected weekly were used to investigate what kind of constructions learners use to express evaluation and how these interact and develop over time. The results show that when a new construction is acquired in the L2, another related construction might regress. The results also point to increased variability in the construction during a phase of rapid development and reduced variability in the phases of regression or slower progress. These findings add to our understanding of a developing L2 as a system in which cha…
The role of motor system in action-related language comprehension in L1 and L2: An fMRI study
2018
The framework of embodied cognition has challenged the modular view of a language-cognition divide by suggesting that meaning-retrieval critically involves the sensory-motor system. Despite extensive research into the neural mechanisms underlying language-motor coupling, it remains unclear how the motor system might be differentially engaged by different levels of linguistic abstraction and language proficiency. To address this issue, we used fMRI to quantify neural activations in brain regions underlying motor and language processing in Chinese-English speakers’ processing of literal, metaphorical, and abstract language in their L1 and L2. Results overall revealed a response in motor ROIs …
From conceptualization to constructions in Finnish as an L2 : a case study
2017
AbstractThis study traces the individual learning trajectories of an adult beginner L2 Finnish learner in expressing the extralinguistic concept of evaluation from a dynamic usage-based perspective. Our results provide support for the view of learner language as a dynamic system in which patterns wax and wane and in which a change in one component has the potential to affect the whole system. In the early stages of learning there was a strong preference to use lexical verbs first, and then adjectives. The study also shows that variability plays a role. Finally, the study confirms that the learning of L2 constructions is in some cases item based. However, another highly frequent and superfic…