Search results for " Fact"
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Endoderm development requires centrioles to restrain p53-mediated apoptosis in the absence of ERK activity
2021
Centrioles comprise the heart of centrosomes, microtubule-organizing centers. To study the function of centrioles in lung and gut development, we genetically disrupted centrioles throughout the mouse endoderm. Surprisingly, removing centrioles from the endoderm did not disrupt intestinal growth or development but blocked lung branching. In the lung, acentriolar SOX2-expressing airway epithelial cells apoptosed. Loss of centrioles activated p53, and removing p53 restored survival of SOX2-expressing cells, lung branching, and mouse viability. To investigate how endodermal p53 activation specifically killed acentriolar SOX2-expressing cells, we assessed ERK, a prosurvival cue. ERK was active t…
Digital control circuitry for the p53 dynamics in cancer cell and apoptosis
2010
Abstract Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in a feedback. This paper proposes an aerospace-based architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutua…
Association between socioeconomic factors and origin of hospital referrals among patients with oral cancer.
2022
The Brazilian Unified Health System (SUS) is responsible for offering free assistance to more than 100 million Brazilians, including treatment of oral cancer lesions. Considering that the Brazilian public system aids the most vulnerable population, this study analyzed whether the origin of hospital referrals of patients with oral cancer is associated with socioeconomic factors. A cross-sectional study was carried out from cancer hospital records of the National Cancer Institute (RHC-INCA), considering the primary locations (C00 to C06) diagnosed between 2016 and 2019. Data on gender, skin color (white and non-white), education (no schooling, incomplete or complete elementary education; high…
The Spatial Extent of Pain Is Associated with Pain Intensity, Catastrophizing and Some Measures of Central Sensitization in People with Frozen Should…
2021
The aim of this cross-sectional study was to explore the spatial extent of pain and its association with clinical symptoms, psychological features, and pain sensitization in people with frozen shoulder (FS). Forty-eight individuals with FS completed pain drawings (PDs) and reported their clinical symptoms including pain intensity (Visual Analogue Scale) and shoulder disability (Shoulder Pain and Disability Index). Moreover, pain sensitization measurements (pressure pain thresholds, temporal summation, conditioned pain modulation, and Central Sensitization Inventory (CSI)) were assessed. Psychological features were assessed by Pain Catastrophizing Scale (PCS) and Pain Vigilance and Awareness…
Evolutionary Dynamics of Pathoadaptation Revealed by Three Independent Acquisitions of the VirB/D4 Type IV Secretion System in Bartonella
2017
The α-proteobacterial genus Bartonella comprises a group of ubiquitous mammalian pathogens that are studied as a model for the evolution of bacterial pathogenesis. Vast abundance of two particular phylogenetic lineages of Bartonella had been linked to enhanced host adaptability enabled by lineage-specific acquisition of a VirB/D4 type IV secretion system (T4SS) and parallel evolution of complex effector repertoires. However, the limited availability of genome sequences from one of those lineages as well as other, remote branches of Bartonella has so far hampered comprehensive understanding of how the VirB/D4 T4SS and its effectors called Beps have shaped Bartonella evolution. Here, we repor…
Additional file 1: of An SNP-based saturated genetic map and QTL analysis of fruit-related traits in Zucchini using Genotyping-by-sequencing
2017
Phenotyped traits in the RIL population. (DOCX 13 kb)
Additional file 2 of Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses
2020
Additional file 2: Fig. S1. Treatment of mice with rIL-4 or rIL-13 induces a Th2 response and RELM-β overexpression in response to primary Echinostoma caproni and infection but not resistance to infection. (A) expression of cytokine mRNA in the intestinal tissue of rIL-4-treated or rIL-13-treated mice at 2 weeks post-primary infection with E. caproni; (B) expression of RELM-β mRNA in the intestinal tissue (F) of naïve mice, non-infected rIL-4- or rIL-13-treated mice and infected rIL-4- or rIL-13-treated mice at 2 weeks post-primary infection. The relative quantities (RQ) of cytokine genes are shown after normalization with β-actin and standardization of the relative amount against day 0 sam…
The parental bond, resistance to peer influence and risky driving in adolescence
2014
The present study examined the relations between gender, the parental bond, resistance to peer influence, and risky driving. In particular, the mediating role of resistance to peer pressure in the relationship between parental bond and risky driving was examined. The moderating role of gender on these associations was also investigated. The sample comprised 322 adolescents (136 males and 186 females), aged from 16 to 20 years, who were living in northern Italy. Path analysis results showed that the maternal bond only indirectly influenced adolescents’ risky driving, via resistance to peer influence. On the contrary, the paternal bond was neither directly nor indirectly associated with risky…
Reģistrētās partnerattiecības un to normatīvā regulējuma ieviešanas iespējas Latvijā.
2020
Maģistra darbs veltīts nereģistrēto kopdzīves partneru attiecību problemātikai Latvijas tiesiskajā telpā nolūkā identificēt problēmu loku, ar ko sastopas kopdzīvē dzīvojoši partneri, un izvērtēt, vai pastāv nepieciešamība izstrādāt papildu tiesiskos mehānismus partnerattiecību nodrošināšanai un aizsardzībai. Darba mērķis ir izpētīt partnerattiecību institūta ieviešanas iespējas Latvijā, analizējot citu valstu normatīvos aktus, un izstrādāt priekšlikumus tam, kā ir iespējams sakārtot tiesisko bāzi nacionālajā līmenī. Darba ietvaros autore izpētīja partnerattiecību institūta rašanās vēsturi, veica nereģistrēto partnerattiecību un laulības tiesību salīdzinošu analīzi, apskatot citu valstu part…
Global Trends in Scientific Research on Pediatric Obesity
2022
(1) Introduction: The aim of this study was to analyze scientific production, collaboration among countries, and research topics focusing on pediatric obesity. (2) Methods: The papers that were included in the study were retrieved from the Web of Science Core Collection from Clarivate Analytics. A bibliometric analysis of several focuses, including journals of publication, subject categories, most frequent author keywords, and journal impact factors, was conducted. Social network analysis was used to recognize collaboration groups between countries and the co-occurrences of author keywords. (3) Results: A total of 12,171 research articles were published in 2036 journals classified under a v…