Search results for " Form"
showing 10 items of 4997 documents
Stability of Asymmetric Lipid Bilayers Assessed by Molecular Dynamics Simulations
2009
The asymmetric insertion of amphiphiles into biological membranes compromises the balance between the inner and outer monolayers. As a result, area expansion of the receiving leaflet and curvature strain may lead to membrane permeation, shape changes, or membrane fusion events. We have conducted both atomistic and coarse-grained molecular dynamics simulations of dipalmitoyl-phosphatidylcholine (DPPC) bilayers to study the effect of an asymmetric distribution of lipids between the two monolayers on membrane stability. Highly asymmetric lipid bilayers were found to be surprisingly stable within the submicrosecond time span of the simulations. Even the limiting case of a monolayer immersed in …
A Tool to Assess Architectural Education from the Sustainable Development Perspective and the Students' Viewpoint
2021
[EN] Architectural education plays a fundamental role in achieving sustainable development by training future professionals who can contribute to sustainability through their practice. Nevertheless, to ensure the introduction of sustainable development in the education of future architects, it is fundamental to understand what is being done and what could be improved. Despite this, a big gap has been detected in the assessment of architectural education in Spain and worldwide. Thus, a close-ended questionnaire for students has been designed based on the outcomes from a literature review, exploratory interviews with specialists, and the qualitative analysis of two schools of architecture. Ad…
Músicas alternativas. Sobre formas de gestionar y producir músicas durante la década de 1980 en Córdoba- Argentina
2021
La producción fluida. El almacén como forma logística en la nueva era industrial
2021
Intermolecular oxidative dehydrogenative 3,3′-coupling of benzo[b]furans and benzo[b]thiophenes promoted by DDQ/H+: total synthesis of shandougenine B
2016
With an excess of a strong acid, 2,3-dichloro-5,6-dicyano-1,4-quinone (DDQ) is shown to promote metal-free intermolecular oxidative dehydrogenative (ODH) 3,3'-coupling of 2-aryl-benzo[b]furans and 2-aryl-benzo[b]thiophenes up to 92% yield as demonstrated with 9 substrates. Based on the analysis of oxidation potentials and molecular orbitals combined with EPR, NMR and UV-Vis observations, the studied reaction is initiated by a DDQ-substrate charge transfer complex and presumably proceeds via oxidation of the substrate into an electrophilic radical cation that further reacts with another molecule of a neutral substrate. The coupling reactivity can easily be predicted from the oxidation potent…
Lie Algebras Generated by Extremal Elements
1999
We study Lie algebras generated by extremal elements (i.e., elements spanning inner ideals of L) over a field of characteristic distinct from 2. We prove that any Lie algebra generated by a finite number of extremal elements is finite dimensional. The minimal number of extremal generators for the Lie algebras of type An, Bn (n>2), Cn (n>1), Dn (n>3), En (n=6,7,8), F4 and G2 are shown to be n+1, n+1, 2n, n, 5, 5, and 4 in the respective cases. These results are related to group theoretic ones for the corresponding Chevalley groups.
1RM BENCH PRESS PERFORMANCE: A NEW METHOD OF EVALUATION IN RECREATIONAL MALE AND FEMALE
2014
It is widely recognised that the 1 RM bench press test is the most valid in evaluating the upper body maximal strength in both athletes and sedentary individuals. Various approaches are used for its evaluation, both through prediction equations or practical attempts. The aim of this study was to assess a new method to perform the bench press test combining previously validated theoretical and practical procedures. Fifteen participants (8 male Age=23.5±2.3 FM%=17.3±9.2 and 7 female Age=27.9±10 FM%=25.6±6.9) with no specific training history were tested. Physiological parameters ware recorded before, during and after each test. Participants had to perform a set of repetitions to fatigue (RTF)…
Izvēlētu benzoskābes atvasinājumu kristalizācijā iegūtās polimorfās formas nosakošo apstākļu un kontroles iespēju pētījums
2020
Polimorfo formu izzināšana un iegūšana ir svarīgs posms farmācijā. Stabilākās formas mēdz būt ar trūkumiem, piemēram, zemu biopieejamību, līdz ar to šis medikaments jālieto lielākās devās. Mainot kristālisko struktūru, var optimizēt zāļu vielu parametrus. Līdz šim nav atklāts vispārīgs mehānisms kā varētu kontrolēt polimorfo formu iznākumus. Viens no mehānismiem ir piedevu jeb templātu izmantošana. Pētījumā apkopota informācija par 2,6-dimetoksibenzoskābes un 3-hidroksibenzoskābes kristāliskajām formām, kuras iegūtas dažādos apstākļos, ar dažādām piedevām un pētījumā izmantotajām metodēm. Eksperimentālajā daļā veikta pētāmo vielu kristālisko formu iegūšana un MD simulācijas, lai noskaidrotu…
De la maison au " village" . Les origines de la morphologie de l'habitat dispersé dans les montagnes de la Savoie du nord
2002
Dans les hautes vallées savoyardes, le peuplement d'avant l'invasion touristique était caractérisé par une implantation en hameaux dispersés à travers le territoire communal. Dispersion relative en Savoie du sud (Maurienne, Tarentaise, Combe de Savoie) où les hameaux étaient fédérés par un « chef-lieu » qui était un véritable bourg ; dispersion fréquemment absolue en Savoie du nord (Faucigny, Chablais), où le chef-lieu n'avait souvent pas plus d'importance que les écarts. C'est aux massifs mo...
Essential omega-3 fatty acids tune microglial phagocytosis of synaptic elements in the developing brain
2019
SUMMARYOmega-3 fatty acids (n-3 polyunsaturated fatty acids; n-3 PUFAs) are essential for the functional maturation of the brain. Westernization of dietary habits in both developed and developing countries is accompanied by a progressive reduction in dietary intake of n-3 PUFAs. Low maternal intake of n-3 PUFAs has been linked to neurodevelopmental diseases in epidemiological studies, but the mechanisms by which a n-3 PUFA dietary imbalance affects CNS development are poorly understood. Active microglial engulfment of synaptic elements is an important process for normal brain development and altered synapse refinement is a hallmark of several neurodevelopmental disorders. Here, we identify …