Search results for " Form"
showing 10 items of 4997 documents
Predicting the in vivo release from a liposomal formulation by IVIVC and non-invasive positron emission tomography imaging
2010
This study aimed to predict the in vivo performance from the in vitro release of a low-molecular weight model compound, [(18)F]-2-fluoro-2-deoxy-d-glucose ([(18)F]FDG), from liposomes and by means of positron emission tomography (PET). Liposomes composed of hydrogenated phosphatidylcholine (HPC) were prepared by a freeze-thaw method. Particle size distribution was measured by dynamic light scattering (DLS). In vitro release was examined with a dispersion method detecting the radioactivity of [(18)F]FDG. In vivo release of [(18)F]FDG, following i.p. injection of the liposomes in rats, was determined by using a Micro-PET scanner. Convolution was performed to predict the in vivo profiles from …
Analysis of the Scoring Formula of Economic Criteria in Public Works Procurement
2013
[EN] Public works procurement regulates two award procedures from within the same criteria: either the price or a variety of different conditions. Although the question of price may not seem the most important factor to be considered, it is imperative to always be aware of it when bearing in mind the award criteria. Economic scoring formulae (ESF) are numerous and each agency has the authority to determine which will be used for each of their bids, making this article a comparative analysis of all the options. The results show that most formulas give the highest score to the most economic bidder, it is necessary to eliminate the use of formulas that give the highest score to the offers whic…
Palladium-catalyzed heteroaryl thioethers synthesis overcoming palladium dithiolate resting states inertness: Practical road to sulfones and NH-sulfo…
2018
International audience; We provide efficient synthetic access to heteroaryl sulfones in two-steps using a simple palladium-1,1'-bis [(diphenyl)phosphanyl]ferrocene catalyst to form in high yields variously functionalized heteroaromatic thioethers. Pyridinyl-containing substrates can be subsequently selectively oxidized into sulfones and NH-sulfoximines by using very mild oxidation conditions with a high functional group tolerance. In the palladium catalyzed C-S coupling of heteroaromatic thiols, reactivity limitation is attached with electron-deficient thiols. We show that this limitation can be resolved by the successful use of 2-bromoheteroarenes in the C-S coupling. We established herein…
Effects of Infant Formula With Human Milk Oligosaccharides on Growth and Morbidity: A Randomized Multicenter Trial
2017
Objectives:The aim of the study was to evaluate the effects of infant formula supplemented with 2 human milk oligosaccharides (HMOs) on infant growth, tolerance, and morbidity. Methods:Healthy infants, 0 to 14 days old, were randomized to an intact-protein, cow's milk-based infant formula (control, n=87) or the same formula with 1.0g/L 2fucosyllactose (2FL) and 0.5g/L lacto-N-neotetraose (LNnT) (test, n=88) from enrollment to 6 months; all infants received standard follow-up formula without HMOs from 6 to 12 months. Primary endpoint was weight gain through 4 months. Secondary endpoints included additional anthropometric measures, gastrointestinal tolerance, behavioral patterns, and morbidit…
Museums which pay attention to education for sustainability
2006
En el presente trabajo analizamos el contenido de dos importantes museos franceses que han empezado a incorporar de forma clara y extensa, no meramente incidental, la atención a la actual situación de emergencia planetaria. Se trata de dos ejemplos notables de superación todavía parcial de la orientación tradicional de los museos como meros exponentes propagandísticos de los logros científicos y de respuesta positiva a los llamamientos de Naciones Unidas para que todos los educadores contribuyamos a favorecer la participación ciudadana en la toma de decisiones fundamentadas, generando actitudes y comportamientos orientados a la consecución de un futuro sostenible. This paper analyzes the co…
N-valproyl-L-tryptophan for CNS-targeting: synthesis, characterization and efficacy in vitro studies of a new potential antiepileptic drug.
2010
A new aminoacidic derivative of valproic acid (VPA) has been synthesized and characterized by analytical and spectral data. The rationale for the preparation of such potential antiepileptic agent is based on the observation that chemical combination of the anticonvulsant pharmacophore, VPA with essential aminoacids could afford more effective and less toxic actives. The synthesis, characterization, physico-chemical parameters functional for crossing Blood Brain Barrier of N-valproyl-L-tryptophan (4) are reported. The Log D pH7.4 (0.3) indicates that (4) is adequate to cross biological membranes. Its chemical and enzymatic stability were assessed. The experiments indicate high stability of c…
Digital information receiver based on stochastic resonance
2003
International audience; An electronic receiver based on stochastic resonance is presented to rescue subthreshold modulated digital data. In real experiment, it is shown that a complete data restoration is achieved for both uniform and Gaussian white noise.
Wave propagation in 1D elastic solids in presence of long-range central interactions
2011
Abstract In this paper wave propagation in non-local elastic solids is examined in the framework of the mechanically based non-local elasticity theory established by the author in previous papers. It is shown that such a model coincides with the well-known Kroner–Eringen integral model of non-local elasticity in unbounded domains. The appeal of the proposed model is that the mechanical boundary conditions may easily be imposed because the applied pressure at the boundaries of the solid must be equilibrated by the Cauchy stress. In fact, the long-range forces between different volume elements are modelled, in the body domain, as central body forces applied to the interacting elements. It is …
On X-saturated formations of finite groups
2005
[EN] In the paper, a Frattini-like subgroup associated with a class X of simple groups is introduced and analysed. The corresponding X-saturated formations are exactly the X-local ones introduced by Förster. Our techniques are also very useful to highlight the properties and behaviour of omega-local formations. In fact, extensions and improvements of several results of Shemetkov are natural consequences of our study.
The influence of proper vine pruning techniques on crop formation and quality of the grapes
2018
We have established the importance of proper vine pruning techniques depending on individual grape variety characteristics and its influence on crop formation and quality of the grapes. The technique of studying the influence of the length of the vine pruning on the qualitative indices of the fruit of the grapes has been proposed. Field research was carried out in 2014-2016. Agricultural technology in the experiment is commonly used for forest-steppe. The vines are planted on the plot without irrigation, the shape of the shrubs is harp multy sleeved with a knot of substitution, sheltered on a vertical trellis of 1.5 m heigh. The methods that can be used to increase the yield of grape variet…