Search results for " GaN"

showing 10 items of 417 documents

Dynamics, alterations, and consequences of minimally invasive intraocular pressure elevation in rats.

2014

PURPOSE: An important, yet not exclusive, aspect of primary open angle glaucoma is elevated intraocular pressure (IOP) profiles within fluctuations and pressure peaks. The study aimed at establishing minimally invasive methods for recurrent IOP elevation in rats to investigate the impact of IOP dynamics and pathomorphologic retinal alterations during and after IOP elevation. METHODS: Intraocular pressure was elevated unilaterally in Long Evans rats to a level of ≈35 mm Hg for 1 hour in a total of 30 manipulations within 6 weeks, by using two methods: (1) suction-cup oculopression and (2) loop-adjusted oculopression. Retinal thickness (RT) was measured via optical coherence tomography (OCT),…

Retinal degenerationMaleRetinal Ganglion Cellsmedicine.medical_specialtyIntraocular pressuregenetic structuresOpen angle glaucomachemistry.chemical_compoundTonometry OcularOptical coherence tomographyOphthalmologymedicineAnimalsRats Long-EvansRetinal thinningIntraocular Pressuremedicine.diagnostic_testbusiness.industryRetinal DegenerationRetinalmedicine.diseaseeye diseasesRatsDisease Models Animalmedicine.anatomical_structureRetinal ganglion cellchemistryAnesthesiaOptic nerveDisease Progressionsense organsbusinessGlaucoma Open-AngleTomography Optical CoherenceFollow-Up StudiesInvestigative ophthalmologyvisual science
researchProduct

Retinal neurodegenerative changes in the adult insulin receptor substrate-2 deficient mouse.

2014

Abstract Insulin receptor substrate-2 (Irs2) mediates peripheral insulin action and is essential for retinal health. Previous investigations have reported severe photoreceptor degeneration and abnormal visual function in Irs2-deficient mice. However, molecular changes in the Irs2 − / −  mouse retina have not been described. In this study, we examined retinal degenerative changes in neuronal and glial cells of adult (9- and 12-week old) Irs2 − / −  mice by immunohistochemistry. 9-week old Irs2 − / −  mice showed significant thinning of outer retinal layers, concomitant to Muller and microglial cell activation. Photoreceptor cells displayed different signs of degeneration, such as outer/inner…

Retinal degenerationRetinal Ganglion CellsRetinal Bipolar Cellsgenetic structuresOuter plexiform layerBiologyRetinal ganglionCellular and Molecular Neurosciencechemistry.chemical_compoundMicemedicineElectroretinographyAnimalsVision OcularRetinaMicroscopy Confocalmedicine.diagnostic_testRetinal DegenerationRetinalmedicine.diseaseInner plexiform layerImmunohistochemistrySensory SystemsCell biologyMice Inbred C57BLOphthalmologyMicroglial cell activationDisease Models Animalmedicine.anatomical_structurechemistryInsulin Receptor Substrate Proteinssense organsNeuroscienceElectroretinographyPhotoreceptor Cells VertebrateExperimental eye research
researchProduct

Historia del convento de Santa Clara de Gandía.

1848

Santa Clara (Convent : Gandia Comunitat Valenciana) HistòriaConvents Història
researchProduct

Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in M…

2020

The subthalamic nucleus (STN), a key component of the basal ganglia circuitry, receives inputs from broad cerebral cortical areas and relays cortical activity to subcortical structures. Recent human and animal studies have suggested that executive function, which is assumed to consist of a set of different cognitive processes for controlling behavior, depends on precise information processing between the cerebral cortex and subcortical structures, leading to the idea that the STN contains neurons that transmit the information required for cognitive processing through their activity, and is involved in such cognitive control directly and dynamically. On the other hand, the STN activity also …

Serial reaction timeCognitive NeuroscienceNeuroscience (miscellaneous)impulsivityBiologyNeurotransmissionImpulsivitylcsh:RC321-57103 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicineDevelopmental NeuroscienceBasal gangliamedicinelcsh:Neurosciences. Biological psychiatry. NeuropsychiatryOriginal Research030304 developmental biology0303 health sciencessubthalamic nucleusCognitionattentionIntracellular signal transductionSubthalamic nucleusmedicine.anatomical_structure5-choice serial reaction time tasknervous systemCerebral cortexDREADDmedicine.symptomNeuroscience030217 neurology & neurosurgeryNeuroscienceFrontiers in Systems Neuroscience
researchProduct

The Chaperone System in Salivary Glands: Hsp90 Prospects for Differential Diagnosis and Treatment of Malignant Tumors

2022

Salivary gland tumors represent a serious medical problem and new tools for differential diagnosis and patient monitoring are needed. Here, we present data and discuss the potential of molecular chaperones as biomarkers and therapeutic targets, focusing on Hsp10 and Hsp90. The salivary glands are key physiological elements but, unfortunately, the information and the means available for the management of their pathologies, including cancer, are scarce. Progress in the study of carcinogenesis has occurred on various fronts lately, one of which has been the identification of the chaperone system (CS) as a physiological system with presence in all cells and tissues (including the salivary gland…

Settore BIO/16 - Anatomia UmanaOrganic ChemistryAntineoplastic AgentsGeneral MedicineSettore MED/08 - Anatomia PatologicaSalivary Gland NeoplasmsSalivary GlandsCatalysisComputer Science ApplicationsDiagnosis DifferentialInorganic ChemistryHumanschaperone system differential diagnosis Ganetespib Hsp90 Hsp90 biomarker Hsp90 pathogenic negative chaperonotherapysalivary gland tumors Diagnosis Differential Humans Molecular Chaperones Salivary Glands Antineoplastic Agents Salivary Gland NeoplasmsHSP90 Heat-Shock ProteinsPhysical and Theoretical Chemistrysalivary gland tumors; chaperone system; Hsp90; Hsp90 pathogenic; negative chaperonotherapy; Ganetespib; Hsp90 biomarker; differential diagnosisMolecular BiologySpectroscopyMolecular Chaperones
researchProduct

Giuseppe Samonà e la “spina dorsale” di Gibellina Nuova

2020

Nel 1970 Giuseppe Samonà coordina il gruppo di progettazione formato da Vittorio Gregotti, Gianni Pirrone e Alberto Samonà per il Progetto del Centro civico, commerciale e culturale di Gibellina Nuova. Del piano è realizzato il municipio e poi, rielaborato e in altro luogo, il teatro. I monumenti, fondati su un asse pedonale in quota connesso a un suolo artificiale articolato, esprimono l’unità architettura – urbanistica e anticipano, per certi versi, una riflessione successiva del Direttore dello IUAV sulla dialettica fra urbano e rurale.

Settore ICAR/14 - Composizione Architettonica E UrbanaIn 1970 Giuseppe Samonà coordinated a design team (with Vittorio Gregotti Gianni Pirrone and Alberto Samonà) for the project of the Civic Commercial and Cultural Centre of Gibellina Nuova. From this plan among the monuments just the town hall was built. The theatre was proposed later for a different place. The buildings should have been linked to a pedestrian axial gangway connected to an articulated artificial ground. The complex should have shown the unity between architecture and urban planning anticipating in some ways a later Samona’s reflection about the dialectic between urban and rural.
researchProduct

ARCHITETTURA E BOTANICA DEL SACRO CALVARIO DI GANGI (SICILIA)

2011

Il Calvario, dal latino Golgota che indica il luogo della Crocifissione di Cristo, è una tipologia di monumento di culto della religione cristiana la cui genesi si fa risalire al Medioevo, epoca dei lunghi pellegrinaggi di fedeli che, per tale ragione, sentivano l’esigenza di creare luoghi sostitutivi che richiamassero le mete Sante, troppo lontane. In Italia e, in particolare, in Piemonte e in Lombardia, l’edificazione di questi complessi prese inizio a seguito del Concilio di Trento soprattutto sotto forma di Sacri Monti che, per l’appunto, ne costituiscono la principale espressione. In Sicilia, la tradizione dei “Calvari” venne introdotta nel XVIII secolo dai Gesuiti che generalmente li …

Settore ICAR/15 - Architettura Del PaesaggioArchitettura botanica giardino calvario Gangi
researchProduct

Il delitto di "caporalato" tra diritti minimi della persona e tutela del mercato del lavoro

2020

Il contributo analizza il reato di intermediazione illecita e sfruttamento lavorativo, offrendo un’analisi comparata con il sistema repressivo tedesco. Lo studio si sofferma, in particolare, sui limiti di legittimazione del diritto penale nella punizione dei fatti di “caporalato”, nel tentativo di scongiurare che l’intervento repressivo nelle dinamiche economiche e contrattuali, di natura sinallagmatica, possa assumere una portata tale da porsi in contrasto con il canone della sussidiarietà. A tal fine, si suggerisce una prospettiva ermeneutica che incentri il disvalore penale del reato di cui all’art. 603-bis c.p. sulla lesione dei diritti fondamentali del lavoratore – riconducibili agli a…

Settore IUS/17 - Diritto PenaleThe paper analyses the offence of unlawful work intermediation and exploitation offering a comparative analysis with the German punitive system. The study focuses in particular on the limits of legitimacy of criminal law in the punishment of gangmaster acts in the attempt to avoid that the punitive intervention in economic and contractual dynamics of a mutual nature could be so intrusive to be in contrast with the principle of subsidiarity. To this end the author suggests an interpretative perspective that centres the penal disvalue of the offence under article 603-bis of the criminal code on the harm to fundamental workers’ rights – as linked to articles 4 35 and 36 of the Italian Constitutions – which work as a limit to entrepreneurial freedom. To be sure the indexes of exploitation listed by the criminalising norm seem to echo those fundamental human rights attributed to a person as a worker: those very same rights that – when harmed in their minimal and therefore intangible dimension – legitimise the intervention of the ius terribile. The article also stresses the protection of the job market: in this sense the offence – even if situated within the Kernstrafrecht – represents a new paradigm of the institutional response within the framework of the contemporary relationships between law and economics.
researchProduct

Desobediencia civil y teoría del derecho Tomar los conflictos en serio

2016

El tema de la desobediencia civil se centra en una de las cuestiones clásicas de la filosofía del derecho, como es aquella de la obligatoriedad de la ley injusta. Sin embargo, hoy en día, las prácticas de desobediencia civil plantean también otras cuestiones, que se debaten de forma polémica, como la tesis de la «separabilidad» entre el derecho y la moral y la naturaleza de la interpretación jurídica de los documentos normativos que tienen un contenido vago y ambiguo, como es el caso de la Constitución Italiana o la Española. En particular, analizamos el caso de las prácticas de desobediencia de carácter público y no violento que violan algunas normas con la finalidad de denunciar no sólo s…

Settore IUS/20 - Filosofia Del DirittoDesobediencia civil. Ley Injusta. Separación entre derecho y moral. Obligo político Obligo moral. Scarpelli. Nino. Dworkin. Rawls Thoureau. Gandhi. Neoconstitucionalismo. Revolución. Objeción de conciencia.
researchProduct

Ceramiche, marmi e pietre. Note di archeologia tra Sicilia e Creta

2012

Settore L-ANT/08 - Archeologia Cristiana E MedievaleAnfore medievali archeologia medievale archeologia islamica Agrigento Gangivecchio Creta archeologia tardoantica topografia archeologia postmedievale mattonelle smaltate ceramica
researchProduct