Search results for " Genes"

The ATXN1 and TRIM31 genes are related to intelligence in an ADHD background: evidence from a large collaborative study totaling 4,963 subjects

2010

Contains fulltext : 96400.pdf (Publisher’s version ) (Closed access) Intelligence is a highly heritable trait for which it has proven difficult to identify the actual genes. In the past decade, five whole-genome linkage scans have suggested genomic regions important to human intelligence; however, so far none of the responsible genes or variants in those regions have been identified. Apart from these regions, a handful of candidate genes have been identified, although most of these are in need of replication. The recent growth in publicly available data sets that contain both whole genome association data and a wealth of phenotypic data, serves as an excellent resource for fine mapping and …

Role for Chromatin Remodeling Factor Chd1 in Learning and Memory

2019

Precise temporal and spatial regulation of gene expression in the brain is a prerequisite for cognitive processes such as learning and memory. Epigenetic mechanisms that modulate the chromatin structure have emerged as important regulators in this context. While posttranslational modification of histones or the modification of DNA bases have been examined in detail in many studies, the role of ATP-dependent chromatin remodeling factors (ChRFs) in learning- and memory-associated gene regulation has largely remained obscure. Here we present data that implicate the highly conserved chromatin assembly and remodeling factor Chd1 in memory formation and the control of immediate early gene (IEG) r…

Denitrifying microbial communities along a boreal stream with varying land-use

2019

Streams have an important role in regulating nitrogen (N) transportation from terrestrial ecosystems to downstream waters. Here, we examined how catchment land-use affects potential denitrification rates and the function and composition of denitrifier communities in boreal stream sediments, using stable isotope incubations and qPCR and 454-pyrosequencing targeted on nirS, nirK and nosZ genes. Although land-use influenced the water chemistry as higher nitrite + nitrate (NO x − ) concentration at the agriculture-affected sampling point, sediment organic matter content was found to be the key factor in regulating potential denitrification rates. However, the abundance as well as the diversity …

The effect of peracetic acid on microbial community, water quality, nitrification and rainbow trout (Oncorhynchus mykiss) performance in recirculatin…

2020

Microbial biofilters control water quality and enable the overall function of recirculation aquaculture systems (RAS). Changes in environmental conditions can affect the abundance and interactions of the diverse microbial populations of the biofilter, affecting nitrification of harmful ammonium and thus fish health. Here, we examined the effect of different application frequencies (0, 1, 2 and 4 times per week) of a common disinfectant, peracetic acid (PAA, applied 1.1 mg l−1 twice per day), on biofilter microbial communities, focusing especially on nitrifying microbial groups and using a high throughput sequencing of 16S rRNA gene and quantitative PCR (qPCR). In addition, we measured biofi…

12q21 Interstitial Deletions: Seven New Syndromic Cases Detected by Array-CGH and Review of the Literature.

2022

Interstitial deletions of the long arm of chromosome 12 are rare, with a dozen patients carrying a deletion in 12q21 being reported. Recently a critical region (CR) has been delimited and could be responsible for the more commonly described clinical features, such as developmental delay/intellectual disability, congenital genitourinary and brain malformations. Other, less frequent, clinical signs do not seem to be correlated to the proposed CR. We present seven new patients harboring non-recurrent deletions ranging from 1 to 18.5 Mb differentially scattered across 12q21. Alongside more common clinical signs, some patients have rarer features such as heart defects, hearing loss, hypotonia an…

MELANOMA FAMILIARE. ANALISI DEI RISULTATI DELLO SCREENING DELLA MUTAZIONE DEL GENE CDKN2A NELLA POPOLAZIONE SICILIANA.

"Auttaminen on molemminpuolinen ilo!" : avustaviin perheenjäseniin perustuva auttaminen suomalaisissa perheyrityksissä auttajan näkökulmasta tarkaste…

2013

Sensitivity to acetic acid, ability to colonize abiotic surfaces and virulence potential of Listeria monocytogenes EGD-e after incubation on parsley …

2010

International audience; Abstract Aim: To investigate how the survival of Listeria monocytogenes on parsley leaves may affect its ability to sustain process-related harsh conditions and its virulence. Methods and Results: Parsley seedlings were spot inoculated with stationary phase cells of L. monocytogenes EGD-e and incubated for 15 days. Each day, bacterial cells were harvested and enumerated, and their ability to survive acetic acid challenge (90 min, pH 4.0), to colonize abiotic surfaces and to grow as biofilms was assessed. After a 3-log decrease over the first 48 h, the population stabilized to about 10(6) CFU g(-1) until the sixth day. After the sixth day, L. monocytogenes was no long…

Validation and application of a PCR primer set to quantify fungal communities in the soil environment by real-time quantitative PCR

2011

Fungi constitute an important group in soil biological diversity and functioning. However, characterization and knowledge of fungal communities is hampered because few primer sets are available to quantify fungal abundance by real-time quantitative PCR (real-time Q-PCR). The aim in this study was to quantify fungal abundance in soils by incorporating, into a real-time Q-PCR using the SYBRGreen (R) method, a primer set already used to study the genetic structure of soil fungal communities. To satisfy the real-time Q-PCR requirements to enhance the accuracy and reproducibility of the detection technique, this study focused on the 18S rRNA gene conserved regions. These regions are little affec…

Theoretical study concept of the genesis of a city with regard to simulation modelling of the long-term development of a transportation network. With…

2018

Artykuł przedstawia zarys rozważań dotyczących teoretycznej koncepcji badania genezy miasta. Proponowany koncept odnosi się do zamysłu zbadania podstaw ilościowych dla znacznego wydłużenia w przeszłość genezy miasta. Proces powstawania miasta powinien odnosić się do działań osadniczych znacznie starszych niż pierwsze ślady procesu urbanizacyjnego i koncentrować się na przejawach działań związanych z przemieszczaniem i transportem. Działania te mogą być rozpoznane w źródłach archeologicznych. Metodologicznie przedstawiona koncepcja bazuje na aplikacji procedury modelowej ORION ze szczególnym naciskiem położonym na długofalowy rozwój sieci transportowej. W artykule opisana została metoda bada…