Search results for " Glu"
showing 10 items of 2355 documents
Stronger C -odd color charge correlations in the proton at higher energy
2023
The non-forward eikonal scattering matrix for dipole-proton scattering at high energy obtains an imaginary part due to a $C$-odd three gluon exchange. We present numerical estimates for the perturbative Odderon amplitude as a function of dipole size, impact parameter, their relative azimuthal angle, and light-cone momentum cutoff $x$. The proton is approximated as $\psi_\mathrm{qqq}|qqq\rangle + \psi_\mathrm{qqqg}|qqqg\rangle$, where $\psi_\mathrm{qqq}$ is a non-perturbative three quark model wave function while the gluon emission is computed in light-cone perturbation theory. We find that the Odderon amplitude increases as $x$ decreases from 0.1 to 0.01. At yet lower $x$, the reversal of t…
Rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes): A multicenter retrospective nationwide Italian study a…
2017
Background Randomized controlled trials (RCTs) in the field of diabetes have limitations inherent to the fact that design, setting, and patient characteristics may be poorly transferrable to clinical practice. Thus, evidence from studies using routinely accumulated clinical data are increasingly valued. Aims We herein describe rationale and design of the DARWIN-T2D (DApagliflozin Real World evIdeNce in Type 2 Diabetes), a multicenter retrospective nationwide study conducted at 50 specialist outpatient clinics in Italy and promoted by the Italian Diabetes Society. Data synthesis The primary objective of the study is to describe the baseline clinical characteristics (particularly HbA1c) of pa…
Evidence for region-specific effects of glucagone-like peptide-2 in mouse stomach
2009
EtG Quantification in Hair and Different Reference Cut-Offs in Relation to Various Pathologies: A Scoping Review
2022
Ethyl glucuronide (EtG) is a non-volatile, non-oxidative, hydrophilic, and stable ethanol phase II metabolite. EtG is produced through ethanol glucuronidation by UDP-glucuronosyltransferase (UGT), a phase II enzyme. EtG can be extracted from different biological matrices, including keratin ones, such as hair or nails. The purpose of this scoping review is to describe the relationship between EtG levels in hair and some of the most common and frequent pathological conditions and verify whether different reference cut-offs in relation to various pathologies have been identified in the scientific literature. In fact, in-depth knowledge of the influence of pathologies, such as diabetes mellitus…
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.
2003
Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that mediate phospholipase D (PLD) activation in brain, but the mechanism underlying this response remains unclear. Here we used primary cultures of astrocytes as a cell model to explore the mechanism that links mGluRs to PLD. Glutamate activated both phospholipase C (PLC) and PLD with equal potency and this effect was mimicked by L-cysteinesulfinic acid, a putative neurotransmitter previously shown to activate mGluRs coupled to PLD, but not PLC, in adult brain. PLD activation by glutamate was dependent on Ca(2+) mobilization and fully blocked by both protein kinase C (PKC) inhibitors and PKC down-regulation, suggesti…
Mucin 1 deficiency mediates corticosteroid insensitivity in asthma
2019
BACKGROUND: The loss of corticosteroid efficacy is an important issue in severe asthma management and may lead to poor asthma control and deterioration of airflow. Recent data indicate that Mucin 1 (MUC1) membrane mucin can mediate corticosteroid efficacy in chronic rhinosinusitis, but the role of MUC1 in uncontrolled severe asthma is unknown. The objective was to analyze the previously unexplored role of MUC1 on corticosteroid efficacy in asthma. METHODS: Mucin 1 expression was evaluated by real-time PCR in human bronchial epithelial cells (HBEC) and blood neutrophils from uncontrolled severe asthma (n=27), controlled mild asthma (n=16), and healthy subjects (n=13). IL-8, MMP9, and GM-CSF …
Interaction of Dioxouranium(VI) ion with aspartate and glutamate in NaClaq at different ionic strengths
2005
The formation of complexes species of the dioxouranium(VI) ion with aspartic and glutamic acids was studied in the pH range of 3 to 6 at 25 °C by potentiometric measurements (H+-glass electrode). Results gave evidence for the formation of the following species: (UO2)A0, (UO2)AH+, and (UO2)2A(OH)2 0 (A2- ) a glutamic or aspartic ligand). Investigations were carried out in a NaCl ionic medium at I (0.1, 0.25, 0.5, and 1.0) mol L-1. The dependence on ionic strength of the formation constants was analyzed by the specific ion interaction theory (SIT) model. The formation constants at infinite dilution, obtained using this model, are log â110 ) 8.53 ( 0.03, 8.37 ( 0.05; log â111 ) 13.60 ( 0.05, 1…
“Indagine sperimentale per la caratterizzazione meccanica di elementi strutturali misti in legno-acciaio e legno-acciaio-calcestruzzo"
2009
The paper reports the results of the research activity aimed to define the physical-mechanics characteristics of structural elements made of wood-steel, and/or wood-steel-concrete, jointed by steel con¬nectors. The elements used for the tests are: glulam beams with two dif¬ferent dimensions (110x240x4000 mms and 110x140x4000 mms); steel flats 100x6x4000 mms with holes 20 mms arranged like "quinconce"; steel connectors like: flat with 6 mms thickness; 18; angular; polymeric synthetic binder with epoxy base bicomponent (Xepox 40.3/5). Shear tests have been made to define the capacity for deformation and the re¬sistance of the different steel connectors. Moreover, bending tests have been m…
Exercise precision medicine for type 2 diabetics : Targeted benefit or risk?
2023
Concurrent exercise and metformin administration may reduce the acute and chronic effects of exercise on glucose metabolism in patients with type 2 diabetes (T2D). However, several studies suggest that combing metformin and exercise treatment may have no additive effect and even cause adverse effects in T2D patients. This case report aimed to highlight the challenges associated with prescribing exercise to type 2 diabetes patients undergoing metformin treatment. A 67-years old woman was followed-up for 5 months, including assessment of the acute and chronic glucose and lactate metabolism induced by concomitant exercise and metformin. The findings were four-fold: 1) During a high-intensity i…