Search results for " Gs"
showing 10 items of 217 documents
Prof. J. Lautenbacha angļu literaturas vēsture XVI. gadsimtenī
1922
Der Philosoph W. Solowioff und das Judentum [Philosoph W. Solowjow und das Judentum]
1927
Inhaltsverzeichnis: Vorwort 5 l. W. Solowioffs und das Judentum ll. W. Solowioffs Protest gegen den Antisemitismus 17 111. Das religiöse Gewissen erweckt in W. S. lnteresse für das Judentum 22 IV. W. Solowioffs Interesse für Juden 29 V. Die Bekanntschaft mit Juden macht W. S. zu ihrem Apologeten 32 VI. Juden zuverteidigen war für W. S. religiöse und patriotische Pflicht 35 Vll. W. Solowioffs jüdische Apologie 39 Vlll. W. S. über das Verhältnis des Christentums zum Judentum 46 IX. W. S. über die Beziehungen der Evangelien zum Talmud 57 X. W. Solowioffs originelle Polemik. 65 Xl. Widerlegung der nationalen Beschuldigungen 74 Xll. Widerlegung der ökonomischen Beschuldigung 77 Xlll. Wideflegung…
A comparison of two different formulations for Arc Routing Problems on Mixed graphs
2006
[EN] Arc routing problems on mixed graphs have been modelled in the literature either using just one variable per edge or associating to each edge two variables, each one representing its traversal in the corresponding direction. In this paper, and using the mixed general routing problem as an example, we compare theoretical and computationally both formulations as well as the lower bounds obtained from them using Linear Programming based methods. Extensive computational experiments, including some big and newly generated random instances, are presented.
Über die frühen Werke von Carl Gotthard Graß in der Akademischen Bibliothek der Universität Lettlands, über die Freundschaft, Antiquarismus in der Ge…
2020
Orationes tres
1594
Mollīna tipogrāfijā nodrukātas Orationes tres: trīs runas, ko turēja sholarhi (Rīgas rātes prokonsuls Nikolajs Eke; 1541-1623 un sindiks Dāvids Hilhens; 1561-1610) un Domskolas rektors Johans Rīvijs (Rivius, 1528-1596, Domskolas rektors (1589) un inspektors (1594)) reorganizētās Domskolas atjaunošanai veltītajā svinīgajā pasākumā 1589. gada 15. jūlijā. Vairāki grāmatas eksemplāri bija domāti dāvināšanai ievērojamām Rīgas personām, tāpēc iesieti grezni: brūnā ādā, ar Rīgas ģerboni zelta iespiedumā uz vāka. Runu tekstus papildina tabulas, kur fiksēts visu triju skolas klašu stundu plāni. Runu izdošana un iespiešana ilga četrus gadus. Izdevums kavējās dēļ burtstabiņu trūkuma grieķu teksta iesp…
Simultaneous stimulation of GABA and beta adrenergic receptors stabilizes isotypes of activated adenylyl cyclase heterocomplex
2004
Abstract Background We investigated how the synthesis of cAMP, stimulated by isoproterenol acting through β-adrenoreceptors and Gs, is strongly amplified by simultaneous incubation with baclofen. Baclofen is an agonist of δ-aminobutyric acid type B receptors [GABAB], known to inhibit adenylyl cyclase via Gi. Because these agents have opposite effects on cAMP levels, the unexpected increase in cAMP synthesis when they are applied simultaneously has been intensively investigated. From previous reports, it appears that cyclase type II contributes most significantly to this phenomenon. Results We found that simultaneous application of isoproterenol and baclofen specifically influences the assoc…
VentQsys: Low-cost open IoT system for CO2 monitoring in classrooms
2021
AbstractIn educational context, a source of nuisance for students is carbon dioxide ($$CO_2$$ C O 2 ) concentration due to closed rooms and lack of ventilation or circulatory air. Also, in the pandemic context, ventilation in indoor environments has been proven as a good tool to control the COVID-19 infections. In this work, it is presented a low cost IoT-based open-hardware and open-software monitoring system to control ventilation, by measuring carbon dioxide ($$CO_2$$ C O 2 ), temperature and relative humidity. This system provides also support for automatic updating, auto-self calibration and adds some Cloud and Edge offloading of computational features for mapping functionalities. From…
Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell pro…
2013
Abstract The beta3 adrenergic receptor (B3-AR) reportedly induces cell proliferation, but the signaling pathways that were proposed, involving either Gs or Gi coupling, remain controversial. To further investigate the role of G protein coupling in B3-AR induced proliferation, we stimulated primary human myometrial smooth muscle cells with SAR150640 (B3-AR agonist) in the absence or presence of variable G-protein inhibitors. Specific B3-AR stimulation led to an Erk1/2 induced proliferation. We observed that the proliferative effects of B3-AR require two Erk1/2 activation peaks (the first after 3 min, the second at 8 h). Erk1/2 activation at 3 min was mimicked by forskolin (adenylyl-cyclase a…
Vidzemes Lielais Zviedru Kadastrs kā saimniecības vēstures avots
1942
Kadastrs - sistematizēti kādu zemes vai ūdens nogabalu vai citu objektu dati; ar nodokļiem apliekamo zemju saraksts un novērtējums pilsētās un laukos. Zemes kadastru sāka ar zemes uzmērīšanu un vērtēšanu, vienlaikus veicot muižu redukciju, atsavinot lielāko daļu muižas zemju, kuras nodeva Zviedrijas valsts pārziņā. Tas bija labi izstrādāts kadastrs, un to izmantoja no 1691. līdz 1911. gadam, t. i., 220 gadus. Tas pasaulē ir samērā mazpazīstams, un tagadējās Latvijas un Igaunijas teritorijā tam bija tikai lokāla nozīme. Muižu redukcija .17. gs. 2. pusē, pieaugot absolūtisma tendencēm Eiropā, Zviedrijas karalis Kārlis XI (Karl XI) centās nostiprināt varu visā valstī. Viens no pasākumiem bija …
Modeling a Novel Variant of Glycogenosis IXa Using a Clonal Inducible Reprogramming System to Generate "Diseased" Hepatocytes for Accurate Diagnosis.
2022
The diagnosis of inherited metabolic disorders is a long and tedious process. The matching of clinical data with a genomic variant in a specific metabolic pathway is an essential step, but the link between a genome and the clinical data is normally difficult, primarily for new missense variants or alterations in intron sequences. Notwithstanding, elucidation of the pathogenicity of a specific variant might be critical for an accurate diagnosis. In this study, we described a novel intronic variant c.2597 + 5G > T in the donor splice sequence of the PHKA2 gene. To investigate PHKA2 mRNA splicing, as well as the functional consequences on glycogen metabolism, we generated hepatocyte-like ce…