Search results for " HOMO"
showing 10 items of 1143 documents
Type II keratin cDNAs from the rainbow trout: implications for keratin evolution.
2002
From a teleost fish, the rainbow trout Oncorhynchus mykiss, we have cloned and sequenced cDNAs encoding five different type II keratins. The corresponding protein spots, as separated by 2D-PAGE of trout cytoskeletal preparations, have been identified by peptide mass mapping using MALDI mass spectrometry. Three of the sequenced keratins are expressed in the epidermis (subtype IIe), and two in simple epithelia and mesenchymal cells (subtype IIs). The IIs keratins are both orthologs of human K8. This leaves unsequenced only the trace component S3 of the biochemically established trout keratin catalog. A phylogenetic tree has been constructed from a multiple alignment of the rod domains of the …
Identification of a Functional Homolog of the Yeast Copper Homeostasis Gene ATX1 from Arabidopsis1
1998
Abstract A cDNA clone encoding a homolog of the yeast (Saccharomyces cerevisiae) gene Anti-oxidant 1(ATX1) has been identified from Arabidopsis. This gene, referred to as CopperCHaperone(CCH), encodes a protein that is 36% identical to the amino acid sequence of ATX1 and has a 48-amino acid extension at the C-terminal end, which is absent from ATX1 homologs identified in animals. ATX1-deficient yeast (atx1) displayed a loss of high-affinity iron uptake. Expression of CCH in the atx1 strain restored high-affinity iron uptake, demonstrating thatCCH is a functional homolog of ATX1. When overexpressed in yeast lacking the superoxide dismutase geneSOD1, both ATX1 and CCHprotected the cell from t…
Origin of Insulin Receptor-Like Tyrosine Kinases in Marine Sponges
1999
One autapomorphic character restricted to all Metazoa including Porifera [sponges] is the existence of transmembrane receptor tyrosine kinases (RTKs). In this study we screened for molecules from one subfamily within the superfamily of the insulin receptors. The subfamily includes the insulin receptors (InsR), the insulin-like growth factor I receptors, and the InsR-related receptors--all found in vertebrates--as well as the InsR-homolog from Drosophila melanogaster. cDNAs encoding putative InsRs were isolated from the hexactinellid sponge Aphrocallistes vastus, the demosponge Suberites domuncula, and the calcareous sponge Sycon raphanus. Phylogenetic analyses of the catalytic domains of th…
A mutation in the second intracellular loop of the pituitary adenylate cyclase activating polypeptide type I receptor confers constitutive receptor a…
2000
AbstractThe pituitary adenylate cyclase activating polypeptide (PACAP) type I receptor belongs to the glucagon/secretin/vasoactive intestinal polypeptide (VIP) receptor family. We mutated and deleted an amino acid residue (E261) which is located within the second intracellular loop of the rat PACAP type I receptor and which is highly conserved among the receptor family. The wild-type receptor and the mutant receptors were efficiently expressed at the surface of COS-7 cells at nearly the same level and revealed the same high affinity for the agonist PACAP-27. The cAMP contents of COS cells transfected with the E261A, E261Q, and the deletion mutant receptor were 4.6-, 5.7-, and 6.7-fold highe…
EZH2 mutations are frequent and represent an early event in follicular lymphoma
2013
Gain of function mutations in the H3K27 methyltransferase EZH2 represent a promising therapeutic target in germinal center lymphomas. In this study, we assessed the frequency and distribution of EZH2 mutations in a large cohort of patients with follicular lymphoma (FL) (n = 366) and performed a longitudinal analysis of mutation during the disease progression from FL to transformed FL (tFL) (n = 33). Mutations were detected at 3 recurrent mutation hot spots (Y646, A682, and A692) in 27% of FL cases with variant allele frequencies (VAF) ranging from 2% to 61%. By comparing VAF of EZH2 with other mutation targets (CREBBP, MLL2, TNFRSF14, and MEF2B), we were able to distinguish patients harbori…
Marx y Engels y la división sexual del trabajo en la familia: ambigüedades, equívocos y vacíos teóricos
2018
Dada la importante influencia de Marx y Engels en el análisis de la estructura social, no sorprende el notable impacto de su obra en el estudio del papel de la mujer en la familia. Sin embargo, su herencia en este ámbito sociológico ha dado lugar a interpretaciones muy polarizadas. Este artículo quiere aportar algo de luz evidenciando las contradicciones del marxismo al estudiar el papel de la mujer en la familia. Para ello se comparan las contribuciones de Marx y Engels para calibrar posibles diferencias en las posturas de dos autores que en otros ámbitos han presentado un pensamiento muy homogéneo. Los resultados obtenidos permiten afirmar que, a pesar de su innegable influencia en el pen…
Riflessioni critiche sulla potenza destituente nel pensiero di Giorgio Agamben
Il presente lavoro di ricerca intende offrire una rilettura del pensiero di Giorgio Agamben alla luce della pubblicazione di L’uso dei corpi, volume con cui si conclude il ventennale progetto “Homo sacer”. In particolare, si discuteranno alcune nozioni fondamentali della filosofia agambeniana – nuda vita, stato di eccezione, inoperosità, forma-di-vita – a partire dalla formulazione conclusiva, ma non definitiva, che il filosofo propone nel libro in questione, per poi focalizzare l’attenzione sulla categoria nella quale si condensa l’intero percorso filosofico di Agamben: la “potenza destituente”. Quest’ultima viene definita come una potenza in grado di disattivare e rendere inoperosa la mac…
"El mestizaje de culturas en el cine español homosexual contemporáneo : Pedro Almodóvar / Ventura Pons"
2005
International audience
Molecular and cytological characterization of homozygous plants of Citrus clementina Hort. ex Tan., candidates to citrus genome sequencing. .
2010
Kompleksy metali przejściowych z zasadami Lewisa jako prekursory katalizatorów polimeryzacji olefin. Cz. I. Postęp w komputerowym modelowaniu procesu…
2001
A review with 35 references covering molecular modeling in coordination polymerization over homogeneous and heterogeneous Ziegler-Natta catalysts. The study includes supports, cocatalysts, Lewis bases and solvents. Recent progress in elucidating the mechanisrn of elementary polymerization steps is presented against the background of rapidly deveIoping computational methods and available computational power. Theoretical studies on polymerization mcchanisms and structure of active centers are described (egns. 1-4). Authors own calculations are used to compare [MtC14(THF)2] complex-based (Mt = Ti, Hf or Zr) heterogeneous catalysts. The geometrical characteristics of precursors is presented (Ta…