Search results for " HOMO"

Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family

2011

Fibroblast growth factor receptor 1 (FGFR1) is known to be activated by homodimerization in the presence of both the FGF agonist ligand and heparan sulfate glycosaminoglycan. FGFR1 homodimers in turn trigger a variety of downstream signaling cascades via autophosphorylation of tyrosine residues in the cytoplasmic domain of FGFR1. By means of Bioluminescence Energy Resonance Transfer (BRET) as a sign of FGFR1 homodimerization, we evaluated in HEK293T cells the effects of all known FGF agonist ligands on homodimer formation. A significant correlation between BRET(2) signaling and ERK1/2 phosphorylation was observed, leading to a further characterization of the binding and signaling properties…

Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling

2014

The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…

Obstruction theory in action accessible categories

2013

Abstract We show that, in semi-abelian action accessible categories (such as the categories of groups, Lie algebras, rings, associative algebras and Poisson algebras), the obstruction to the existence of extensions is classified by the second cohomology group in the sense of Bourn. Moreover, we describe explicitly the obstruction to the existence of extensions in the case of Leibniz algebras, comparing Bourn cohomology with Loday–Pirashvili cohomology of Leibniz algebras.

The Abel–Jacobi map for higher Chow groups

2006

We construct a map between Bloch's higher Chow groups and Deligne homology for smooth, complex quasiprojective varieties on the level of complexes. For complex projective varieties this results in a formula which generalizes at the same time the classical Griffiths Abel–Jacobi map and the Borel/Beilinson/Goncharov regulator type maps.

Pseudodifferential Analysis on Manifolds with Boundary — a Comparison of b-Calculus and Cone Algebra

2001

We establish a relation between two different approaches to a complete pseudodifferential analysis of totally characteristic or Fuchs type operators on compact manifolds with boundary respectively conical singularities: Melrose’s (overblown) b-calculus and Schulze’s cone algebra. Though quite different in their definition, we show that these two pseudodifferential calculi basically contain the same operators.

The module structure of Hochschild homology in some examples

2008

Abstract In this Note we give a simple proof of a conjecture by A. Caldararu stating the compatibility between the modified Hochschild–Kostant–Rosenberg isomorphism and the action of Hochschild cohomology on Hochschild homology in the case of Calabi–Yau manifolds and smooth projective curves. To cite this article: E. Macri` et al., C. R. Acad. Sci. Paris, Ser. I 346 (2008).

Kontsevich formality and cohomologies for graphs

2004

A formality on a manifold M is a quasi isomorphism between the space of polyvector fields (Tpoly(M)) and the space of multidifferential operators (Dpoly(M)). In the case M=R d , such a mapping was explicitly built by Kontsevich, using graphs drawn in configuration spaces. Looking for such a construction step by step, we have to consider several cohomologies (Hochschild, Chevalley, and Harrison and Chevalley) for mappings defined on Tpoly. Restricting ourselves to the case of mappings defined with graphs, we determine the corresponding coboundary operators directly on the spaces of graphs. The last cohomology vanishes.

Quantum Groups, Star Products and Cyclic Cohomology

1993

After some historical remarks, we start with a rapid overview of the star-product theory (deformation of algebras of functions on phase space) and its applications to deformation-quantization. We then concentrate on Poisson-Lie groups and their “quantization”, give a star-product realization of quantum groups and discuss uniqueness and the rigidity as bialgebra of a universal model for the quantum SL(2) groups. In the last part we develop the notion of closed star-product (for which a trace can be defined on the algebra), show that it is classified by cyclic cohomology, permits to define a character and that there always exists one; finally we show that the pseudodifferential calculus on a …

A note on conjugation involutions on homotopy complex projective spaces

1986

Mismatch G-T binding activity and MSH2 expression is quantitatively related to sensitivity of cells to methylating agents

1998

To elucidate mechanisms involved in alkylating drug resistance, Chinese hamster cells resistant to methylating agents have been generated upon transfection with human DNA. Here it is shown that these Chinese hamster ovary (CHO) variants exhibit the tolerance phenotype: they are alkyltransferase deficient (Mex-), cross-resistant to 6-thioguanine, exhibit reduced G-T binding (MutS alpha) activity and express the mismatch repair protein MSH2 at a significantly lower level than the corresponding control. By comparing wild-type cells with different tolerant strains that show gradual differences in resistance to methylating agents, it was shown that both the G-T binding activity and the amount of…