Search results for " Head and neck"

showing 9 items of 69 documents

Is immunohistochemistry more sensitive than hematoxylin-eosin staining for identifying perineural or lymphovascular invasion in oral squamous cell ca…

2021

This study aimed to analyze whether immunohistochemistry (IHC) is more sensitive than hematoxylin-eosin (H&E) staining for identifying perineural invasion (PNI) or lymphovascular invasion (LVI) in oral squamous cell carcinoma (OSCC). In this systematic review and meta-analysis (Prospective Register of Systematic Reviews ? CRD 42021256515), data were obtained from six databases (PubMed, Scopus, LILACS, Web of Science, EBSCO, LIVIVO, Embase) and the grey literature. Cross-sectional observational studies of the diagnostic sensitivity of IHC for PNI and LVI were included. Studies were selected in two phases: first collection and reference retrieval. The Quality Assessment of Diagnostic Accuracy…

Staining and LabelingSquamous Cell Carcinoma of Head and NeckneoplasmsImmunohistochemistrystomatitisCross-Sectional StudiesOtorhinolaryngologyHead and Neck NeoplasmsLymphatic MetastasisCarcinoma Squamous Cellantineoplastic agentsmicrobiotaEosine Yellowish-(YS)HumansMouth NeoplasmsNeoplasm InvasivenessSurgeryimmunotherapyHematoxylinGeneral DentistryUNESCO:CIENCIAS MÉDICASMedicina Oral Patología Oral y Cirugia Bucal
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Bioinformatics analysis of TP53 gene in head and neck squamous cell carcinoma patients from the cancer genome atlas

2019

TP53 gene head and neck squamous cell carcinoma
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Pharmacological genome demethylation increases radiosensitivity of head and neck squamous carcinoma cells

2011

Aberrant inactivation of tumor suppressor genes by promoter hypermethylation has been recognized as a crucial step of tumor development and is related to aggressiveness and therapy resistance. To identify potential novel treatment strategies, we evaluated pharmacological genome demethylation for the increase of irradiation treatment effectiveness in head and neck squamous cell carcinoma (HNSCC) in this in vitro study. HNSCC cells were cultured with 2 different concentrations of 5-azacytidine (5-Aza) for 72 h, followed by a single fraction irradiation with 4 or 50 Gy, respectively. To show successful genome demethylation, the methylation status of the tumor suppressor gene hic1 (hypermethyla…

Transcriptional ActivationAntimetabolites AntineoplasticTumor suppressor geneBisulfite sequencingBiologyRadiation ToleranceCell Line TumorGeneticsmedicineHumansRadiosensitivityPromoter Regions GeneticDemethylationOncogeneSquamous Cell Carcinoma of Head and NeckGeneral MedicineDNA MethylationCell cyclemedicine.diseaseHead and neck squamous-cell carcinomaSquamous carcinomaGene Expression Regulation NeoplasticHead and Neck NeoplasmsAzacitidineCarcinoma Squamous CellCancer researchInternational Journal of Molecular Medicine
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Sepsis in head and neck cancer patients treated with chemotherapy and radiation: literature review and consensus

2015

Abstract: The reporting of infection/sepsis in chemo/radiation-treated head and neck cancer patients is sparse and the problem is underestimated. A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of infections and sepsis. The Delphi appropriateness method was used for this consensus. External expert reviewers then evaluated the conclusions carefully according to their area of expertise. The paper contains seven clusters of statements about the clinical definition and management of infections and sepsis in head and neck cancer patients, which had a consensus. Furthermore, it offers a revie…

cancer patientpathogenesipositron emission tomographyhealthcare associated infectionSettore MED/06 - Oncologia Medicapatient monitoringradiodiagnosimedicine.medical_treatmentChemotherapy; Head and neck cancer; Radiotherapy; SepsisthrombocytopeniaReviewblood cultureorgan injurymedical terminologyMedicineHead and neck cancermetabolic acidosiC reactive proteinHead and Neck Neoplasmmedical specialisttreatment withdrawalconsensus developmentHematologyclinical practicesystemic inflammatory response syndromeItalyOncologyHead and Neck Neoplasmslaboratory testthrombocytosichemically induced/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingchemotherapy; head and neck cancer; radiotherapy; sepsis; oncology; hematology; geriatrics and gerontologyorgan perfusionhospitalizationHumansepsis Head and Neck Neoplasmmedicine.medical_specialtySettore MED/17 - Malattie InfettiveSepsibacterium culturediagnostic approach routefluorodeoxyglucosecancer chemotherapySepsisSDG 3 - Good Health and Well-beingSepsiscancer radiotherapyfollow upChemotherapyHumansinfection riskIntensive care medicineprocalcitonin antimicrobial therapyChemotherapyRadiotherapybusiness.industrydisease predispositionHead and neck cancerlactic acidChemotherapy; Head and neck cancer; Radiotherapy; Sepsis; Humans; Italy; Head and Neck Neoplasms; Sepsis; Hematology; Oncology; Geriatrics and Gerontologymedicine.diseasemortalityDelphi studyRadiation therapyinflammationincidencehyperglycemiaHuman medicineGeriatrics and Gerontologybusiness
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Head–Neck Cancer Delineation

2021

Head–Neck Cancer (HNC) has a relevant impact on the oncology patient population and for this reason, the present review is dedicated to this type of neoplastic disease. In particular, a collection of methods aimed at tumor delineation is presented, because this is a fundamental task to perform efficient radiotherapy. Such a segmentation task is often performed on uni-modal data (usually Positron Emission Tomography (PET)) even though multi-modal images are preferred (PET-Computerized Tomography (CT)/PET-Magnetic Resonance (MR)). Datasets can be private or freely provided by online repositories on the web. The adopted techniques can belong to the well-known image processing/computer-vision a…

medicine.medical_specialtyComputer sciencemedicine.medical_treatmentImage processinghead–neck cancer (HNC)Head neck cancerlcsh:Technology030218 nuclear medicine & medical imagingTask (project management)head and neck squamous cell carcinoma (HNSCC)lcsh:Chemistry03 medical and health sciencestumor delineation0302 clinical medicinemedicineGeneral Materials ScienceMedical physicsSegmentationlcsh:QH301-705.5InstrumentationSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniFluid Flow and Transfer Processesmedicine.diagnostic_testlcsh:Tbusiness.industryProcess Chemistry and TechnologyDeep learningsegmentationGeneral EngineeringCT Head and neck squamous cell carcinoma (HNSCC) Head–neck cancer (HNC) MRI Nasopharyngeal cancer (NPC) PET Segmentation Tumor delineationnasopharyngeal cancer (NPC)lcsh:QC1-999Computer Science ApplicationsRadiation therapylcsh:Biology (General)lcsh:QD1-999lcsh:TA1-2040Positron emission tomography030220 oncology & carcinogenesisArtificial intelligenceTomographylcsh:Engineering (General). Civil engineering (General)businesslcsh:PhysicsCTApplied Sciences
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Radiomics and radiogenomics in head and neck squamous cell carcinoma: Potential contribution to patient management and challenges

2021

Abstract The application of imaging biomarkers in oncology is still in its infancy, but with the expansion of radiomics and radiogenomics a revolution is expected in this field. This may be of special interest in head and neck cancer, since it can promote precision medicine and personalization of treatment by overcoming several intrinsic obstacles in this pathology. Our goal is to provide the medical oncologist with the basis to approach these disciplines and appreciate their main uses in clinical research and clinical practice in the medium term. Aligned with this objective we analyzed the most relevant studies in the field, also highlighting novel opportunities and current challenges.

medicine.medical_specialtyDecision MakingRadiogenomicsPersonalizationMedium termMachine LearningRadiomicsBiomarkers TumormedicineHumansRadiology Nuclear Medicine and imagingMedical physicsPrecision MedicineSquamous Cell Carcinoma of Head and Neckbusiness.industryHead and neck cancerGeneral MedicinePrognosismedicine.diseasePrecision medicineHead and neck squamous-cell carcinomaPatient managementOncologyHead and Neck NeoplasmsbusinessDiagnostic Techniques RadioisotopeCancer Treatment Reviews
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Treatment patterns in older patients with locally advanced head and neck squamous cell carcinoma

2021

OBJECTIVES: We aimed to assess patterns of care delivered to older patients with locally advanced head and neck squamous cell carcinoma (LA-HNSCC), and to analyze the use of geriatric assessment (GA) and assessment of quality of life (QoL).MATERIALS AND METHODS: Members of the head and neck cancer group and the older task force of the European Organisation for Research and Treatment of Cancer (EORTC), members the European Head and Neck Society and members of national groups in Europe were asked to complete a questionnaire about treatment delivered, use of GA, and QoL assessment in older patients with LA-HNSCC.RESULTS: Investigators from 111 centers replied, including 90 (81.1%) academic cen…

medicine.medical_specialtyLocally advancedMEDLINE03 medical and health sciences0302 clinical medicineQuality of lifeSurveys and QuestionnairesmedicineHumans030212 general & internal medicineProspective cohort studyAgedbusiness.industrySquamous Cell Carcinoma of Head and NeckHead and neck cancerCancermedicine.diseaseHead and neck squamous-cell carcinomaCANCERhumanitiesOncologyOropharyngeal CarcinomaHead and Neck Neoplasms030220 oncology & carcinogenesisPhysical therapyCarcinoma Squamous CellQuality of LifeGeriatrics and GerontologybusinessJournal of Geriatric Oncology
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Transoral robotic surgery vs open surgery in head and neck cancer: a systematic review of the literature

2020

Background TORS has become one of the latest surgical alternatives in the treatment of oropharynx squamous cell carcinomas (OPSCC) and has become increasingly accepted by surgeons as a treatment option. Surgical robots were designed for various purposes, such as allowing remote telesurgery, and eliminating human factors like trembling. The study aimed to compare systematic review of the available literature in order to evaluate the safety and efficacy of Transoral Robotic Surgery (TORS) compared with open surgery. Material and Methods We performed a systematic review of the available literature in order to evaluate the safety and effectiveness of TORS compared with open surgery. We compared…

medicine.medical_specialtyMEDLINEReviewRessenyes sistemàtiques (Investigació mèdica)Head cancer03 medical and health sciences0302 clinical medicineRobotic Surgical ProceduresSystematic reviews (Medical research)Transoral robotic surgerymedicineHumansGeneral DentistrySurvival rateCàncer de capSquamous Cell Carcinoma of Head and Neckbusiness.industryOpen surgeryGeneral surgeryHead and neck cancer030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]Neck cancerCàncer de collOropharyngeal NeoplasmsTreatment OutcomeSystematic reviewOtorhinolaryngologyHead and Neck NeoplasmsUNESCO::CIENCIAS MÉDICASCarcinoma Squamous CellSurgeryObservational studyOral SurgerybusinessSurgical robotRobots
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Hypovitaminosis D, oral potentially malignant disorders, and oral squamous cell carcinoma: a systematic review

2021

Oral squamous cell carcinoma (OSCC) and potentially malignant oral disorders (OPMDs) could be associated with low levels of vitamin D. This systematic review aimed to determine the relationship between serum levels of vitamin D with OPMDs and OSCC. This review was conducted according to Cochrane guidelines (PROSPERO CRD42020207382) on literature retrieved from the PubMed, Cochrane, and Web of Science databases. The antecedents extracted were study design, methodology, sample (country, number of patients, age, and sex), oral manifestations (type of lesion, location, prevalence, and follow-up), serum vitamin D levels or use of vitamin D supplements, results, and conclusions. Twelve articles w…

retromolar foramenmandibular nerveSquamous Cell Carcinoma of Head and Neckct scanretromolar canalhelical scanVitamin D Deficiencymandibular canalOtorhinolaryngologyHead and Neck NeoplasmsCarcinoma Squamous CellHumansinferior alveolar nerveMouth NeoplasmsSurgeryretromolar triangleGeneral DentistryUNESCO:CIENCIAS MÉDICASMedicina Oral Patología Oral y Cirugia Bucal
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