Search results for " Helix"
showing 10 items of 106 documents
Which regions produce the most innovation policy research?
2022
[EN] This article uses the data indexed in the Web of Science Core Collection and Scopus databases up to and including the year 2020 to map leading regions and trending topics in academic innovation policy research. The country analysis highlights four leading regions in this research field: Western Europe (led by the UK, the Netherlands, Germany, and Spain), North America (led by the USA), Scandinavia (led by Sweden and Denmark), and Asia-Pacific (led by China and Australia). The most common keywords are used to develop a conceptual framework. Applying the Tree of Science approach, we classify the most influential studies into three categories: foundational studies (the roots), structural …
A Research Journey from National Systems of Innovation to National Systems of Entrepreneurship: Introducing the Sextuple Helix
2021
[EN] National systems of innovation (NSI) have attracted substantial interest from public administrations, the scientific community and international organizations. Innovation is a key factor for countries to be competitive in the today's global economy. Entrepreneurship is an innovation source that has gained importance in NSI research over the last few decades. This focus on entrepreneurship in the context of NSI has led scholars to propose novel concepts such as entrepreneurial ecosystems and the national system of entrepreneurship (NSE). This paper uses bibliometric methods and the Web of Science Core Collection (WoS CC) database to explore how entrepreneurship fits into NSI research an…
The challenge of a place-based and network approach to the development in the territories
2016
This paper investigates the role of research networks inside local development processes to increase the competitiveness of underdeveloped territories. This paper, within the scope of local development theory, aims to describe the state of the art on the regional research systems resulting largely from programs co-financed between 2000 and 2013, with which the various regions are preparing to engage in programming for the period 2014-2020. The extent of consistency between the objectives of sectorial specialization set by policies previously or currently implemented and those in the planning phase (S3) is assessed, as is their connection with existing territorial specializations at a region…
LA COMPLESSA STRADA VERSO L’INNOVAZIONE NEI TERRITORI
2015
This paper provides a framework on regional research systems, through which, different regions are preparing to engage in program- ming period 2014 – 2020. It will also cover the regions’ investments in the co-financed programs between 2000 and 2013. Particular attention is dedicated to those projects that, in the specific objectives or specific actions have referred to high-tech districts, techno- logical platforms, clusters, innovation centers, science or technology parks and networks. It then carries out two verifications: firstly, of the degree of consistency between policies and implementation and ongoing design (S3) and secondly of their connection with the existing territorial specia…
CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons
2015
Summary Recent studies demonstrate that astroglia from non-neurogenic brain regions can be reprogrammed into functional neurons through forced expression of neurogenic factors. Here we explored the effect of CEND1 and NEUROG2 on reprogramming of mouse cortical astrocytes and embryonic fibroblasts. Forced expression of CEND1, NEUROG2, or both resulted in acquisition of induced neuronal cells expressing subtype-specific markers, while long-term live-cell imaging highlighted the existence of two different modes of neuronal trans-differentiation. Of note, a subpopulation of CEND1 and NEUROG2 double-transduced astrocytes formed spheres exhibiting neural stem cell properties. mRNA and protein exp…
The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma
2021
The multikinase inhibitor sorafenib was the first drug approved by the FDA for treating patients with advanced hepatocellular carcinoma (HCC). However, sorafenib resistance remains a major challenge for improving the effectiveness of HCC treatment. Previously, we identified several genes modulated after sorafenib treatment of human HCC cells, including the stress-inducible nuclear protein 1 (NUPR1) gene. Multiple studies have shown that NUPR1 regulates autophagy, apoptosis, and chemoresistance. Here, we demonstrate that treatment of HCC cells with sorafenib resulted in the activation of autophagic flux. NUPR1 knock-down (KD) in HCC cells was associated with increased p62 expression, suggest…
The in, out Asymmetric Pseudo-Triple Helical Form of a D3h Diaza-Macropentacycle
2007
A sterically encumbered [N(2)S(6)] macropentacycle (5) related to diazamacrobicycles and cryptands has been synthesized in 53% yield by the [1+1] condensation reaction between functionalized macrocyclic and macrotricyclic precursors. A macrononacycle (18) resulting from the corresponding [2+2] condensation was isolated in 7% yield from the reaction mixture. Both compounds showed broad features in their room-temperature (1)H NMR spectra, but their maximal average symmetry (D(3h) and D(2h), respectively) was achieved at high temperature (380 K). At low temperature (200 K, CD(2)Cl(2) solution), the macropentacycle is "frozen" to a single asymmetric (C1) conformation on the (1)H NMR time scale,…
Analysis of the Impact of the Triple Helix on Sustainable Innovation Targets in Spanish Technology Companies
2020
The establishment of broad-based networks, such as the Triple Helix, for innovation and sustainability is sufficiently corroborated. In this work we suggest that the information received from the Triple Helix has a significant and different impact on the objectives of sustainable innovation, depending on whether companies cooperate or not. To this end, an empirical analysis of a stratified sample of more than 5000 Spanish medium and high technology companies in 2010-2014-2015 was carried out. The results confirm that companies that do not cooperate place more importance on the information received from the Triple Helix to establish their sustainable innovation targets.
Transcriptional regulation of the stem cell leukemia gene by PU.1 and Elf-1.
1998
Abstract The SCL gene, also known astal-1, encodes a basic helix-loop-helix transcription factor that is pivotal for the normal development of all hematopoietic lineages. SCL is expressed in committed erythroid, mast, and megakaryocytic cells as well as in hematopoietic stem cells. Nothing is known about the regulation of SCL transcription in mast cells, and in other lineages GATA-1 is the only tissue-specific transcription factor recognized to regulate the SCL gene. We have therefore analyzed the molecular mechanisms underlyingSCL expression in mast cells. In this paper, we demonstrate that SCL promoter 1a was regulated by GATA-1 together with Sp1 and Sp3 in a manner similar to the situati…
Transcriptional Mechanisms of Proneural Factors and REST in Regulating Neuronal Reprogramming of Astrocytes
2015
Summary Direct lineage reprogramming induces dramatic shifts in cellular identity, employing poorly understood mechanisms. Recently, we demonstrated that expression of Neurog2 or Ascl1 in postnatal mouse astrocytes generates glutamatergic or GABAergic neurons. Here, we take advantage of this model to study dynamics of neuronal cell fate acquisition at the transcriptional level. We found that Neurog2 and Ascl1 rapidly elicited distinct neurogenic programs with only a small subset of shared target genes. Within this subset, only NeuroD4 could by itself induce neuronal reprogramming in both mouse and human astrocytes, while co-expression with Insm1 was required for glutamatergic maturation. Cu…