Search results for " Heterogeneity"
showing 10 items of 358 documents
Proximal-sensing-powered modelling of energy-water fluxes in a vineyard: A spatial resolution analysis
2021
Spatial resolution is a key parameter in energy–water surface flux modelling. In this research, scale effects are analyzed on fluxes modelled with the FEST-EWB model, by upscaling both its inputs and outputs separately. The main questions are: (a) if high-resolution remote sensing images are necessary to accurately model a heterogeneous area; and (b) whether and to what extent low-resolution modelling provides worse/better results than the upscaled results of high-resolution modelling. The study area is an experimental vineyard field where proximal sensing images were obtained by an airborne platform and verification fluxes were measured via a flux tower. Modelled fluxes are in line with th…
Marginal hazard ratio estimates in joint frailty models for heart failure trials
2019
Abstract This work is motivated by clinical trials in chronic heart failure disease, where treatment has effects both on morbidity (assessed as recurrent non‐fatal hospitalisations) and on mortality (assessed as cardiovascular death, CV death). Recently, a joint frailty proportional hazards model has been proposed for these kind of efficacy outcomes to account for a potential association between the risk rates for hospital admissions and CV death. However, more often clinical trial results are presented by treatment effect estimates that have been derived from marginal proportional hazards models, that is, a Cox model for mortality and an Andersen–Gill model for recurrent hospitalisations. …
La Valle dei Templi in epoca medioevale. Caratterizzazione antropologica e paleopatologica delle sepolture antistanti in Tempio della Concordia
2021
Riassunto ― Il lavoro presenta i risultati delle analisi bio-archeologiche effettuate su resti scheletrici umani rinvenuti in quattordici sepolture di epoca medioevale rinvenute nel Parco Archeologico della Valle dei Templi di Agrigento (Sicilia). L’obiettivo è stato l’acquisizione delle informazioni necessarie per la ricostruzione del profilo biologico di ciascun individuo, al fine di determinarne il sesso, la stima dell’età biologica alla morte, la stima della statura e la valutazione delle patologie e degli indicatori di stress occupazionale mediante le correnti metodologie e tecniche diagnostiche di tipo antropologico. Sebbene il cattivo stato di conservazione di alcuni individui non ne…
Modeling multiple taxis: Tumor invasion with phenotypic heterogeneity, haptotaxis, and unilateral interspecies repellence
2021
We provide a short review of existing models with multiple taxis performed by (at least) one species and consider a new mathematical model for tumor invasion featuring two mutually exclusive cell phenotypes (migrating and proliferating). The migrating cells perform nonlinear diffusion and two types of taxis in response to non-diffusing cues: away from proliferating cells and up the gradient of surrounding tissue. Transitions between the two cell subpopulations are influenced by subcellular (receptor binding) dynamics, thus conferring the setting a multiscale character. We prove global existence of weak solutions to a simplified model version and perform numerical simulations for the full se…
EXOSOMES DERIVED FROM METASTATIC COLON CANCER CELLS TRANSFER MALIGNANT PHENOTYPIC TRAITS TO SURROUNDING CELLS: THEIR EMERGING ROLE IN TUMOR HETEROGEN…
2018
Several studies have clearly demonstrated that within a heterogeneous tumor mass the inter-clonal cooperation between metastatic and non-metastatic cells can facilitate the tumor progression. Recent accumulating evidence has highlighted that tumor-derived exosomes (TDEs) play a relevant role as mediator of the inter-clonal collaborative cooperation affecting the properties of both tumor and non-tumor component. In this context, our goal was to understand if exosomes derived from highly metastatic cells may influence the behaviour of less aggressive tumor cells and the properties of endothelium. We found that metastatic SW620 cells transfer through exosomes (SW620Exos) their round/amoeboid p…
18F-FDG PET for breast cancer : combined analysis of tumour perfusion and metabolism for tumour characterisation and neoadjuvant chemotherapy respons…
2020
Neoadjuvant chemotherapy (NAC) is a common treatment in patients with locally advanced or large breast cancer at diagnosis. A pathological complete response (pCR) at the end of NAC is recognized as a good surrogate marker of relapse-free survival. An early identification of the pathological response has then become a key parameter to monitor new therapeutic strategies. Studies, focusing on predictive biomarkers identification, have shown that early changes in tumour metabolism, assessed by Positron Emission Tomography (PET) using 2-desoxy-2-18F-fluoro-D-glucose (18F-FDG), allow the early assessment of the pathological response at the end of treatment. However, given the diversity of breast …
Latent Class Approach to Estimate the Willingness to Pay for Transit User Information
2012
The aim of analysis is to understand how unreliable information influences user behaviour and how much it discourages public transport use. For this purpose, a Stated Preference Survey was carried out in order to know the preferences of public transport users relating to information needs and uncertainty on the information provided by Advanced Traveller Information System (ATIS). The perceived uncertainty is defined as information inaccuracy. In our study, we consider- ed the difference between forecasted or scheduled waiting time at the bus stop and/or metro station provided by ATIS, and that experienced by user, to catch the bus and/or metro. A questionnaire was submitted to an appropriat…
Kawasaki disease in Sicily: clinical description and markers of disease severity
2016
Background: Kawasaki disease (KD) is an acute systemic vasculitis of small and middle size arteries; 15-25 % of untreated patients and 5 % of patients treated with intravenous immunoglobulin (IVIG) develop coronary artery lesions (CAL). Many studies tried to find the most effective treatment in the management of resistant KD and to select the risk factors for CAL. Our data are assessed on children from west Sicily, characterized by a genetic heterogeneity. Methods: We studied the clinical data of 70 KD Sicilian children (36 males: 51 %; 34 females: 49 %), analysed retrospectively, including: demographic and laboratory parameters; echocardiographic findings at diagnosis, at 2, 6 and 8 weeks,…
A Federated Approach for Interoperating AEC/FM Ontologies
2016
International audience; Over the last few years, the benefits of applying ontologies (semantic graph modelling) for Architecture, Engineering, Construction and Facility Management (AEC/FM) industry have been recognized by several researchers and industry stakeholders. One of the main motivations is because it eases AEC data manipulation and representation. However, a research question that still remains open is how to take advantage of semantic web technologies to interoperate the AEC/FM and other ontologies in a flexible and dynamical way in order to solve data structure heterogeneity problem. Because of this, we propose in this paper to apply a rule-based federated architecture to answer …
COBieOWL, an OWL ontology based on COBie standard
2015
International audience; Building Information Modelling (BIM) standards have been recognized by construction and political actors as a highly promising tool for resolving issues of data dematerialization, notably in the field of Architecture, Engineering, Construction and Facility Management. Among worldwide-adopted BIM standards, there is COBie. COBie’s goals are to dematerialize building data and to enhance building information interoperability. Nevertheless, COBie data is available in static formats such as STEP or spreadsheet templates. Such formats lack logical formalisms and semantic features provided by languages such as OWL. Because of this, in this paper, we propose a method for sem…