Search results for " Homology"
showing 10 items of 633 documents
Expression of the human XPB/ERCC-3 excision repair gene-homolog in the sponge Geodia cydonium after exposure to ultraviolet radiation.
1998
Abstract The marine demosponge Geodia cydonium encodes a gene, termed GCXPB , which displays 62% identity to the human XPB/ERCC-3 gene that specifically corrects the repair defect in xeroderma pigmentosum and in Cockayne's syndrome. The cDNA was isolated and characterized the deduced aa sequence, XPB_GEOCY, with the calculated size of 91,541 Da comprises the characteristic domains found in the related helicases. Phylogenetic tree analysis revealed that the sponge sequence is grouped to the metazoan related XPB/ERCC-3 polypeptides. Northern Blot analyses have been performed with sponge samples collected at different depths, thus exposed to different intensities of UV sunlight in the field. T…
The diversity and evolution of chelicerate hemocyanins
2012
Abstract Background Oxygen transport in the hemolymph of many arthropod species is facilitated by large copper-proteins referred to as hemocyanins. Arthropod hemocyanins are hexamers or oligomers of hexamers, which are characterized by a high O2 transport capacity and a high cooperativity, thereby enhancing O2 supply. Hemocyanin subunit sequences had been available from horseshoe crabs (Xiphosura) and various spiders (Araneae), but not from any other chelicerate taxon. To trace the evolution of hemocyanins and the emergence of the large hemocyanin oligomers, hemocyanin cDNA sequences were obtained from representatives of selected chelicerate classes. Results Hemocyanin subunits from a sea s…
Distinct Clones of Yersinia pestis Caused the Black Death
2010
From AD 1347 to AD 1353, the Black Death killed tens of millions of people in Europe, leaving misery and devastation in its wake, with successive epidemics ravaging the continent until the 18th century. The etiology of this disease has remained highly controversial, ranging from claims based on genetics and the historical descriptions of symptoms that it was caused by Yersinia pestis to conclusions that it must have been caused by other pathogens. It has also been disputed whether plague had the same etiology in northern and southern Europe. Here we identified DNA and protein signatures specific for Y. pestis in human skeletons from mass graves in northern, central and southern Europe that …
Killer toxin-secreting double-stranded RNA mycoviruses in the yeasts Hanseniaspora uvarum and Zygosaccharomyces bailii.
1994
Killer toxin-secreting strains of the yeasts Hanseniaspora uvarum and Zygosaccharomyces bailii were shown to contain linear double-stranded RNAs (dsRNAs) that persist within the cytoplasm of the infected host cell as encapsidated virus-like particles. In both yeasts, L- and M-dsRNAs were associated with 85-kDa major capsid protein, whereas the additional Z-dsRNA (2.8 kb), present only in the wild-type Z. bailii killer strain, was capsid protein, whereas the additional Z-dsRNA (2.8 kb), present only in the wild-type Z. bailii killer strain, was shown to be encapsidated by a 35-kDa coat protein. Although Northern (RNA) blot hybridizations indicated that L-dsRNA from Z. bailii is a LA species,…
Data structures and algorithms for topological analysis
2014
International audience; One of the steps of geometric modeling is to know the topology and/or the geometry of the objects considered. This paper presents different data structures and algorithms used in this study. We are particularly interested by algebraic structures, eg homotopy and homology groups, the Betti numbers, the Euler characteristic, or the Morse-Smale complex. We have to be able to compute these data structures, and for (homotopy and homology) groups, we also want to compute their generators. We are also interested in algorithms CIA and HIA presented in the thesis of Nicolas DELANOUE, which respectively compute the connected components and the homotopy type of a set defined by…
Convergence Rates for Persistence Diagram Estimation in Topological Data Analysis
2014
International audience; Computational topology has recently seen an important development toward data analysis, giving birth to the field of topological data analysis. Topological persistence, or persistent homology, appears as a fundamental tool in this field. In this paper, we study topological persistence in general metric spaces, with a statistical approach. We show that the use of persistent homology can be naturally considered in general statistical frameworks and that persistence diagrams can be used as statistics with interesting convergence properties. Some numerical experiments are performed in various contexts to illustrate our results.
THE HOMOLOGY OF DIGRAPHS AS A GENERALIZATION OF HOCHSCHILD HOMOLOGY
2010
J. Przytycki has established a connection between the Hochschild homology of an algebra $A$ and the chromatic graph homology of a polygon graph with coefficients in $A$. In general the chromatic graph homology is not defined in the case where the coefficient ring is a non-commutative algebra. In this paper we define a new homology theory for directed graphs which takes coefficients in an arbitrary $A-A$ bimodule, for $A$ possibly non-commutative, which on polygons agrees with Hochschild homology through a range of dimensions.
Stable motivic homotopy theory at infinity
2021
In this paper, we initiate a study of motivic homotopy theory at infinity. We use the six functor formalism to give an intrinsic definition of the stable motivic homotopy type at infinity of an algebraic variety. Our main computational tools include cdh-descent for normal crossing divisors, Euler classes, Gysin maps, and homotopy purity. Under $\ell$-adic realization, the motive at infinity recovers a formula for vanishing cycles due to Rapoport-Zink; similar results hold for Steenbrink's limiting Hodge structures and Wildeshaus' boundary motives. Under the topological Betti realization, the stable motivic homotopy type at infinity of an algebraic variety recovers the singular complex at in…
Characterization of a novel selenium methyltransferase from freshwater bacteria showing strong similarities with the calicheamicin methyltransferase
2004
A novel group of Se-methyltransferases is presented. The genetic determinant, named mmtA, which revealed this group was isolated from selenite and selenate-resistant freshwater bacteria. E. coli expressing mmtA and grown with a Se supplement emitted dimethyl selenide (DMSe) and dimethyl diselenide (DMDSe). Phylogenetic analysis divided MmtA-like bacterial sequences into two clusters, one grouping MmtA with S- and O-methyltransferases, and one grouping UbiE C-methyltransferases. Se methylation by some of these MmtA phyletic neighbours was investigated.
Toward the Identification of Two Glycoproteins Involved in the Stomatal Deregulation of Downy Mildew–Infected Grapevine Leaves
2015
SPE Pôle IPM UB; International audience; Stomata remain abnormally opened and unresponsive to abscisic acid in grapevine leaves infected by downy mildew. This deregulation occurs from 3 days post inoculation and increases concomitantly with leaf colonization by the pathogen. Using epidermal peels, we demonstrated that the active compound involved in this deregulation is located in the apoplast. Biochemical assays showed that the active compound present in the apoplastic fluids isolated from Plasmopara viticola infected grapevine leaves (IAF) is a CysCys bridge-independent, thermostable and glycosylated protein. Fractionation guided assays based on chromatography / stomatal response and prot…