Search results for " Homology"
showing 10 items of 633 documents
Negative Regulation of β Enolase Gene Transcription in Embryonic Muscle Is Dependent upon a Zinc Finger Factor That Binds to the G-rich Box within th…
1998
We have previously identified a muscle-specific enhancer within the first intron of the human beta enolase gene. Present in this enhancer are an A/T-rich box that binds MEF-2 protein(s) and a G-rich box (AGTGGGGGAGGGGGCTGCG) that interacts with ubiquitously expressed factors. Both elements are required for tissue-specific expression of the gene in skeletal muscle cells. Here, we report the identification and characterization of a Kruppel-like zinc finger protein, termed beta enolase repressor factor 1, that binds in a sequence-specific manner to the G-rich box and functions as a repressor of the beta enolase gene transcription in transient transfection assays. Using fusion polypeptides of b…
Regulation of the effects of CYP2E1-induced oxidative stress by JNK signaling
2014
The generation of excessive amounts of reactive oxygen species (ROS) leads to cellular oxidative stress that underlies a variety of forms of hepatocyte injury and death including that from alcohol. Although ROS can induce cell damage through direct effects on cellular macromolecules, the injurious effects of ROS are mediated largely through changes in signal transduction pathways such as the mitogen-activated protein kinase c-Jun N-terminal kinase (JNK). In response to alcohol, hepatocytes have increased levels of the enzyme cytochrome P450 2E1 (CYP2E1) which generates an oxidant stress that promotes the development of alcoholic steatosis and liver injury. These effects are mediated in larg…
Obstruction theory in action accessible categories
2013
Abstract We show that, in semi-abelian action accessible categories (such as the categories of groups, Lie algebras, rings, associative algebras and Poisson algebras), the obstruction to the existence of extensions is classified by the second cohomology group in the sense of Bourn. Moreover, we describe explicitly the obstruction to the existence of extensions in the case of Leibniz algebras, comparing Bourn cohomology with Loday–Pirashvili cohomology of Leibniz algebras.
The Abel–Jacobi map for higher Chow groups
2006
We construct a map between Bloch's higher Chow groups and Deligne homology for smooth, complex quasiprojective varieties on the level of complexes. For complex projective varieties this results in a formula which generalizes at the same time the classical Griffiths Abel–Jacobi map and the Borel/Beilinson/Goncharov regulator type maps.
Pseudodifferential Analysis on Manifolds with Boundary — a Comparison of b-Calculus and Cone Algebra
2001
We establish a relation between two different approaches to a complete pseudodifferential analysis of totally characteristic or Fuchs type operators on compact manifolds with boundary respectively conical singularities: Melrose’s (overblown) b-calculus and Schulze’s cone algebra. Though quite different in their definition, we show that these two pseudodifferential calculi basically contain the same operators.
The module structure of Hochschild homology in some examples
2008
Abstract In this Note we give a simple proof of a conjecture by A. Caldararu stating the compatibility between the modified Hochschild–Kostant–Rosenberg isomorphism and the action of Hochschild cohomology on Hochschild homology in the case of Calabi–Yau manifolds and smooth projective curves. To cite this article: E. Macri` et al., C. R. Acad. Sci. Paris, Ser. I 346 (2008).
Kontsevich formality and cohomologies for graphs
2004
A formality on a manifold M is a quasi isomorphism between the space of polyvector fields (Tpoly(M)) and the space of multidifferential operators (Dpoly(M)). In the case M=R d , such a mapping was explicitly built by Kontsevich, using graphs drawn in configuration spaces. Looking for such a construction step by step, we have to consider several cohomologies (Hochschild, Chevalley, and Harrison and Chevalley) for mappings defined on Tpoly. Restricting ourselves to the case of mappings defined with graphs, we determine the corresponding coboundary operators directly on the spaces of graphs. The last cohomology vanishes.
Quantum Groups, Star Products and Cyclic Cohomology
1993
After some historical remarks, we start with a rapid overview of the star-product theory (deformation of algebras of functions on phase space) and its applications to deformation-quantization. We then concentrate on Poisson-Lie groups and their “quantization”, give a star-product realization of quantum groups and discuss uniqueness and the rigidity as bialgebra of a universal model for the quantum SL(2) groups. In the last part we develop the notion of closed star-product (for which a trace can be defined on the algebra), show that it is classified by cyclic cohomology, permits to define a character and that there always exists one; finally we show that the pseudodifferential calculus on a …
Common genetic denominators for Ca++-based skeleton in Metazoa: role of osteoclast-stimulating factor and of carbonic anhydrase in a calcareous spong…
2012
Calcium-based matrices serve predominantly as inorganic, hard skeletal systems in Metazoa from calcareous sponges [phylum Porifera; class Calcarea] to proto- and deuterostomian multicellular animals. The calcareous sponges form their skeletal elements, the spicules, from amorphous calcium carbonate (ACC). Treatment of spicules from Sycon raphanus with sodium hypochlorite (NaOCl) results in the disintegration of the ACC in those skeletal elements. Until now a distinct protein/enzyme involved in ACC metabolism could not been identified in those animals. We applied the technique of phage display combinatorial libraries to identify oligopeptides that bind to NaOCl-treated spicules: those oligop…
Contribution of sponge genes to unravel the genome of the hypothetical ancestor of Metazoa (Urmetazoa)
2001
Recently the term Urmetazoa, as the hypothetical metazoan ancestor, was introduced to highlight the finding that all metazoan phyla including the Porifera (sponges) are derived from one common ancestor. Sponges as the evolutionarily oldest, still extant phylum, are provided with a complex network of structural and functional molecules. Analyses of sponge genomes from Demospongiae (Suberites domuncula and Geodia cydonium), Calcarea (Sycon raphanus) and Hexactinellida (Aphrocallistes vastus) have contributed also to the reconstruction of the evolutionary position of Metazoa with respect to Fungi. Furthermore, these analyses have provided evidence that the characteristic evolutionary novelties…