Search results for " Hormonal"
showing 8 items of 68 documents
Progestogens reduce thromboxane production by cultured human endothelial cells.
2011
Objectives Progestogens have been poorly studied concerning their roles in endothelial physiology. Prostanoids are vasoactive compounds, such as thromboxane A2, a potent vasoconstrictor, and prostacyclin, a vasodilator. We examined the effects of two progestogens used clinically, progesterone and medroxyprogesterone acetate, on thromboxane A2 production by cultured human umbilical vein endothelial cells (HUVEC) and investigated the role of progesterone receptors and the enzymes involved in production of thromboxane A2 and prostacyclin. Methods Cells were exposed to 1‐100 nmol/l of either progesterone or medroxyprogesterone acetate, and thromboxane A2 production was measured in culture mediu…
Tubular carcinoma of the breast: Outcome and loco-regional recurrence in 307 patients
2005
Abstract Purpose The aim of this study is to describe the University of Florence experience in evaluating clinical, pathologic and treatment factors as they are related to the outcome and loco-regional recurrence in patients with tubular breast carcinoma. Material and methods Three hundred and seven patients (median age 56.4 years, range 26–91 years) with histological verified tubular carcinoma of the breast were consecutively treated at University of Florence from 1976 to 2001. All patients were followed for a median of 8.4 years (range 3 months to 20 years). Thirty-seven women underwent mastectomy and 270 underwent breast conserving surgery. Positive axillary nodes were found in 15% of pa…
Neridronate prevents bone loss in patients receiving androgen deprivation therapy for prostate cancer.
2004
Today, androgen deprivation therapy is a cornerstone of treatment for advanced prostate cancer, although it presents important complications such as osteoporosis. Neridronate, a relatively new bisphosphonate, is able to prevent bone loss in patients with prostate cancer during androgen ablation. Introduction: Androgen-deprivation therapy (ADT) is a cornerstone of treatment for advanced prostate cancer. This therapy has iatrogenic complications, such as osteoporosis. The aim of our study was to evaluate the efficacy of neridronate, a relatively new bisphosphonate, to prevent bone loss during androgen ablation. Materials and Methods: Forty-eight osteoporotic patients with prostate cancer, tre…
COMPliance and Arthralgia in Clinical Therapy: the COMPACT trial, assessing the incidence of arthralgia, and compliance within the first year of adju…
2014
5 Office-based Professional Association Gynecologic Oncologists e.V. in Germany (BNGO e.V.), Berlin; 6 Background: This prospective study evaluated the relationship between arthralgia and compliance during the first year of adjuvant anastrozole therapy in postmenopausal women with hormone receptor-positive early breast cancer. Patients and methods: COMPliance and Arthralgia in Clinical Therapy (COMPACT) was an open-label, multicenter, noninterventional study conducted in Germany. Patients had started adjuvant anastrozole 3-6 months before the study start. The primary end points were arthralgia, compliance, and the relationship between compliance and arthralgia, assessed at specific time poi…
Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma. Twelve-year’s results of a phase II study.
2003
OBJECTIVE: To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS: From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance of toxicity. Twenty-five patients (61%) had T3-T4N0M0 and 16 (39%) T2-4N0-3M1 prostate carcinoma. Consensus criteria were adopted to evaluate the response. Plasma testosterone and sexual function were recorded for the first 3 years. RESULTS: Flutamide was administered for up to 147 months; seven patients (17%) interrupted the treatment because of toxicity. There was an object…
Abemaciclib: safety and effectiveness of a unique cyclin-dependent kinase inhibitor
2020
Introduction: The discovery and the clinical availability of novel cyclin-dependent kinases 4 and 6 inhibitors have profoundly changed the therapeutic scenario of metastatic hormone receptor-positive breast carcinoma. Among these inhibitors, abemaciclib can induce potent and sustained cell cycle arrest and immune system stimulation. Areas covered: This review summarizes the safety profile and clinical efficacy data on abemaciclib alone or in combination with aromatase inhibitors or fulvestrant in metastatic hormone receptor-positive breast carcinoma. The management of patients treated with abemaciclib is the object of this paper. Expert opinion: As shown in phase 2 and 3 clinical trials on …
Efectos de un programa de intervención psicoeducativa en la calidad de vida de los/las pacientes durante sus tratamientos de Reproducción Asistida
2021
El término Infertilidad Humana se refiere a la no consecución del embarazo después de 12 meses de mantener relaciones sexuales sin el uso de métodos anticonceptivos. Ha sido reconocido por la Organización Mundial de la Salud (OMS) como un problema de salud pública a nivel global, y aunque existe un alto número de personas con infertilidad, aproximadamente tan sólo la mitad de estas personas buscan tratamientos médicos para lograr concebir. Las personas que se someten a Tratamientos de Reproducción Asistida (TRA) pasan por una serie de etapas en las que sufren distintos tipos de cambios, tanto en su estado físico como emocional. La literatura muestra que durante los tratamientos las mujeres …
Wpływ korekty płci na poczucie jakości życia mężczyzn transpłciowych – wyniki badania pilotażowego oraz przyczynek do dalszych badań
2017
Badanie pilotażowe miało na celu weryfikację doniesień naukowych mówiących o dobrym funkcjonowaniu osób transpłciowych. Na tej podstawie starano się porównać poczucie jakości życia mężczyzn transpłciowych z cispłciowymi mężczyznami heteroseksualnymi, homoseksualnymi i biseksualnymi a także zweryfikować role terapii hormonalnej i operacyjnej korekty płci jako potencjalnych predyktorów poczucia jakości życia mężczyzn transpłciowych. Cispłciowi mężczyźni heteroseksualni wykazywali się istotnie wyższym poczuciem jakości życia w stosunku do członków społeczności LGBTQ (mężczyzn transpłciowych, cispłciowych męż - czyzn homoseksualnych i biseksualnych). Orientacja seksualna mężczyzn transpłciowych…