Search results for " Humans"

showing 10 items of 2466 documents

Minimal manifestation status and prednisone withdrawal in the MGTX trial

2020

ObjectiveTo examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized patients with myasthenia gravis (MG).MethodsThis study is a post hoc analysis of data from a randomized trial of thymectomy in MG (Thymectomy Trial in Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy [MGTX]). MGTX was a multicenter, randomized, rater-blinded 3-year trial that was followed by a voluntary 2-year extension for patients with acetylcholine receptor (AChR) antibody–positive MG without thymoma. Patients were randomized 1:1 to thymectomy plus prednisone vs prednisone alone. Participants were age 18–65 years at enr…

Malemedicine.medical_treatmentAzathioprinelaw.invention0302 clinical medicineRandomized controlled trialPrednisonelawMedicineSingle-Blind Method030212 general & internal medicineYoung adultMiddle AgedThymectomyCombined Modality TherapySubstance Withdrawal Syndrome3. Good healthSettore MED/26 - NEUROLOGIA6.1 PharmaceuticalsAnesthesiaadolescent; adult; animals; combined modality therapy; female; humans; immunosuppressive agents; male; middle aged; myasthenia gravis; prednisone; rats; single-blind method; substance withdrawal syndrome; thymoma; thymus neoplasms; young adult; thymectomyCognitive SciencesFemaleImmunosuppressive Agentsmedicine.drugAdultThymomaAdolescentThymomaClinical Trials and Supportive ActivitiesClinical SciencesMGTX study groupAutoimmune DiseaseArticleYoung Adult03 medical and health sciencesRare DiseasesClinical ResearchMyasthenia GravisPost-hoc analysisAnimalsHumansNeurology & Neurosurgerybusiness.industryNeurosciencesEvaluation of treatments and therapeutic interventionsThymus Neoplasmsmedicine.diseaseMyasthenia gravisRatsThymectomyPrednisoneNeurology (clinical)business030217 neurology & neurosurgeryNeurology
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Early endovascular aneurysm repair after percutaneous coronary interventions

2015

Objective The objective of this study was to report long-term results of early endovascular aortic aneurysm repair after percutaneous coronary intervention (PCI). Methods This was a retrospective analysis of all patients presenting with abdominal aortic aneurysm and coronary artery disease treated during the same hospitalization by endovascular aortic aneurysm repair performed soon after PCI. Primary outcomes were perioperative mortality, perioperative complications, survival after treatment, and freedom from reintervention. Results A total of 20 patients were included, and all completed both procedures. No deaths or abdominal aortic aneurysm ruptures occurred between the PCI and the aortic…

Malemedicine.medical_treatmentCoronary DiseaseComorbidityEndovascular aneurysm repairSettore MED/22 - Chirurgia VascolareCoronary artery diseaseAortic aneurysmPostoperative ComplicationsRisk FactorsRetrospective StudieCause of DeathMyocardial infarctionHospital MortalityAged; Aged 80 and over; Aortic Aneurysm Abdominal; Cause of Death; Combined Modality Therapy; Comorbidity; Coronary Disease; Follow-Up Studies; Hospital Mortality; Humans; Italy; Male; Middle Aged; Postoperative Complications; Reoperation; Retrospective Studies; Risk Factors; Survival Rate; Early Medical Intervention; Percutaneous Coronary Intervention; Cardiology and Cardiovascular Medicine; Surgery; Medicine (all)Aged 80 and overMedicine (all)Middle AgedCombined Modality TherapyAbdominal aortic aneurysm2746 SurgerySurvival RateItalycardiovascular systemCardiologyCardiology and Cardiovascular MedicineHumanReoperationmedicine.medical_specialty10216 Institute of Anesthesiology610 Medicine & health2705 Cardiology and Cardiovascular MedicineFollow-Up StudiePercutaneous Coronary InterventionInternal medicineEarly Medical InterventionmedicineHumanscardiovascular diseasesRetrospective StudiesAgedbusiness.industryRisk FactorPercutaneous coronary interventionPerioperativemedicine.disease10020 Clinic for Cardiac SurgerySurgeryConventional PCISurgeryPostoperative ComplicationbusinessFollow-Up StudiesAortic Aneurysm Abdominal
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Stability and change of lifestyle profiles in cardiovascular patients after their first acute coronary event.

2017

Background Acute coronary syndrome (ACS) is a major cause of morbidity and mortality. Lifestyle and health behavior changes play an important role in the primary and secondary prevention of ACS recurrence. Changes in unhealthy lifestyles after an acute coronary event have been analyzed by considering separate behaviors individually, even though research on the healthy population has demonstrated that unhealthy behaviors tend to co-occur. Purpose The aim of this study was to identify lifestyle profiles of ACS patients and to explore their pathways of change for one year after their first coronary event by adopting a typological approach. Methods Two hundred and twenty-three patients (84% mal…

Malemedicine.medical_treatmentEmotionsHealth BehaviorSocial Scienceslcsh:MedicineAnxiety030204 cardiovascular system & hematologyHabits0302 clinical medicineMedicine and Health SciencesSmoking HabitsSecondary PreventionPsychologyPublic and Occupational Health030212 general & internal medicinelcsh:ScienceDepression (differential diagnoses)Aged 80 and overSecondary preventionCardiac RehabilitationMultidisciplinaryRehabilitationCoronary eventDepressionSmokingMiddle AgedAcute Coronary Syndrome; Adult; Aged; Aged 80 and over; Cardiac Rehabilitation; Exercise; Female; Humans; Male; Middle Aged; Secondary Prevention; Self Report; Smoking; Health Behavior; Healthy Lifestyle; Biochemistry Genetics and Molecular Biology (all); Agricultural and Biological Sciences (all)AnxietyFemaleprevention lifestyles acute coronary syndromemedicine.symptomHealth behaviorBehavioral and Social Aspects of HealthResearch ArticleHumanAdultSettore M-PSI/01 - Psicologia Generalemedicine.medical_specialtyAcute coronary syndrome03 medical and health sciencesMental Health and PsychiatryHeart ratemedicineHumansHealthy LifestyleAcute Coronary SyndromeExerciseNutritionAgedBehaviorBiochemistry Genetics and Molecular Biology (all)Mood Disordersbusiness.industrylcsh:RBiology and Life SciencesHealth Risk AnalysisPhysical Activitymedicine.diseaseDietHealth CareAgricultural and Biological Sciences (all)Physical therapylcsh:QSelf ReportbusinessPLoS ONE
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Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit

2018

PURPOSE: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. METHODS: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. RESULTS: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU len…

Malemedicine.medical_treatmentHSJ UCICritical Care and Intensive Care Medicinelaw.inventionLife sustaining treatment0302 clinical medicineElderlylaw80 and overMedicine030212 general & internal medicineProspective StudiesProspective cohort studyAged 80 and overeducation.field_of_studyWithholding Treatmentddc:617[SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontologyWithholdingIntensive care unit3. Good healthEuropeagedIntensive Care UnitsWithdrawalSOFA scoreHumanmedicine.medical_specialtyethical aspectsPopulationIntensive Care UnitDecision MakingElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholding;life-sustaining therapyNO03 medical and health sciencesIntensive careAnesthesiologyHumansEthiceducationMechanical ventilationEthicsbusiness.industry030208 emergency & critical care medicineElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholdingcritical careLife Support CareProspective StudieWithholding TreatmentIntensive careEmergency medicineElderly; Ethics; Intensive care; Life sustaining treatment; Withdrawal; Withholding; Aged 80 and over; Decision Making; Europe; Humans; Intensive Care Units; Male; Prospective Studies; Life Support Care; Withholding Treatmentbusiness
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Prognostic Role of Late Gadolinium Enhancement in Patients With Hypertrophic Cardiomyopathy and Low-to-Intermediate Sudden Cardiac Death Risk Score

2019

Sudden cardiac death (SCD) is the most life-threating complication of hypertrophic cardiomyopathy. Guidelines of the European Society of Cardiology (ESC) suggest the implantation of an implantable cardioverter defibrillator in primary prevention according to a 5-year risk SCD score >= 6%. The aim of the study is to evaluate the prognostic role of late gadolinium enhancement (LGE) in patients with a 5-year risk SCD score <6%. In this multicenter study, we performed cardiac magnetic resonance in 354 consecutive hypertrophic cardiomy-opathy patients (257 males, range of age 54 +/- 17) with a risk SCD score <6% (302 with <4% and 52 with >= 4 and <6% risk). Hard cardiac events,…

Malemedicine.medical_treatmentLeftCardiomyopathyContrast MediaGadolinium030204 cardiovascular system & hematologyVentricular Function Left030218 nuclear medicine & medical imagingSudden cardiac death0302 clinical medicineRisk Factorshemic and lymphatic diseasesVentricular FunctionFramingham Risk Scoremedicine.diagnostic_testIncidenceHypertrophic cardiomyopathyMiddle AgedImplantable cardioverter-defibrillatorPrognosisMagnetic Resonance ImagingHypertrophic Cardiomyopathy Sudden Cardiac Death.DeathSurvival RateItalyCineCardiologyFemaleCardiology and Cardiovascular MedicineCardiaccongenital hereditary and neonatal diseases and abnormalitiesmedicine.medical_specialtyCardiomyopathyHeart VentriclesMagnetic Resonance Imaging CineRisk Assessment03 medical and health sciencesInternal medicinemedicineHumanscardiovascular diseasesRetrospective Studiesbusiness.industryMyocardiumMagnetic resonance imagingRetrospective cohort studyCardiomyopathy HypertrophicCardiomyopathy Hypertrophic; Contrast Media; Death Sudden Cardiac; Female; Follow-Up Studies; Gadolinium; Heart Ventricles; Humans; Incidence; Italy; Magnetic Resonance Imaging Cine; Male; Middle Aged; Myocardium; Prognosis; ROC Curve; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; Ventricular Function Leftmedicine.diseaseSuddenSudden cardiac deathDeath Sudden CardiacROC CurveHypertrophicComplicationbusinessFollow-Up Studies
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Recommendations of the treatment-resistant depression expert center network for promoting tobacco smoking cessation based on the results from the rea…

2022

Abstract Background Tobacco smoking has been associated with suicide, impulsivity and depression in non-clinical populations with differences across sexes. Objective To determine the role of tobacco smoking in Treatment-Resistant Depression (TRD) according to sex in a precision-medicine approach. Method The FACE-TRD cohort is a national cohort of TRD patients recruited in 13 resistant depression expert centers between 2014 and 2021 and followed-up at 6 months. A standardized one-day long comprehensive battery was carried out, including trained-clinician and patient-reported outcomes, and patients were reevaluated at 6 months on their smoking and psychiatric hospitalization outcomes. Results…

Malemedicine.medical_treatmentMESH: Tobacco SmokingSuicide AttemptedtobaccoMESH: NicotineCohort StudiesDepressive Disorder Treatment-Resistantchemistry.chemical_compoundSurveys and QuestionnairesMedicinePrecision MedicineVareniclineMESH: Cohort StudiesDepression (differential diagnoses)health care economics and organizationseducation.field_of_studypublic mental healthMESH: Middle AgedMESH: Suicidal Ideationpublic healthMiddle AgedMESH: Smoking CessationpsychiatryCohortdepressionMESH: Suicide AttemptedFemalemental healthNicotinemedicine.medical_specialtyPopulationeducationMESH: Precision MedicinesmokingSuicidal IdeationMESH: Depressive Disorder Treatment-ResistantSex FactorsMESH: Sex FactorsTobacco SmokingHumansMESH: Surveys and QuestionnaireseducationPsychiatryBiological PsychiatryPharmacologyMESH: HumansSuicide attemptbusiness.industryOdds ratiomedicine.diseaseMESH: Maleschizophreniachemistry[SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental healthSmoking cessationSmoking CessationbusinessTreatment-resistant depressionMESH: Female
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Long-term outcomes of percutaneous coronary interventions or coronary artery bypass grafting for left main coronary artery disease in octogenarians (…

2014

Percutaneous coronary intervention (PCI) with drug-eluting stents is an accepted alternative to surgery for the treatment of unprotected left main coronary artery (ULMCA) disease, but the long-term outcome in elderly patients is unclear. Aim of our study was to compare the clinical outcomes of octogenarians with ULMCA disease treated either with PCI with drug-eluting stents or coronary artery bypass grafting (CABG). The primary study end point was the composite of death, cerebrovascular accident, and myocardial infarction at follow-up. A total of 304 consecutive patients with ULMCA stenosis treated with PCI or CABG and aged 80 years were selected and analyzed in a large multinational regist…

Malemedicine.medical_treatmentMedizinCoronaryKaplan-Meier EstimateCoronary AngiographyCohort StudiesPostoperative Complications80 and overMyocardial infarctionHospital MortalityRegistriesSurvivorsAngioplasty Balloon CoronaryCoronary Artery BypassAged 80 and overEjection fractionHazard ratioAge FactorsAge Factors; Aged 80 and over; Angioplasty Balloon Coronary; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Coronary Stenosis; Coronary Vessels; Female; Geriatric Assessment; Hospital Mortality; Humans; Kaplan-Meier Estimate; Male; Percutaneous Coronary Intervention; Postoperative Complications; Prognosis; Propensity Score; Registries; Retrospective Studies; Risk Assessment; Survival Analysis; Survivors; Treatment Outcome; Drug-Eluting Stents; Cardiology and Cardiovascular MedicineDrug-Eluting StentsPrognosisCoronary Vesselssurgical procedures operativeTreatment OutcomeDrug-eluting stentCardiologyFemaleCardiology and Cardiovascular Medicinemedicine.medical_specialtyRevascularizationRisk AssessmentPercutaneous Coronary InterventionInternal medicineAngioplastymedicineHumanscardiovascular diseasesPropensity ScoreGeriatric AssessmentAgedRetrospective Studiesbusiness.industryAngioplastyCoronary StenosisPercutaneous coronary interventionmedicine.diseaseSurvival AnalysisSurgeryConventional PCIbusinessBalloon
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Lack of Correlation between Liver Tests Abnormalities and Trabectedin Efficacy in the Treatment of Soft Tissue Sarcoma: A Retrospective Study

2015

AbstractElevation in liver transaminases is common in patients treated with the marine antitumor agent trabectedin. However, the impact of trabectedin-related transaminase elevations on treatment outcomes is unclear. This retrospective study investigated the correlation between liver tests abnormalities and treatment outcomes in patients with unresectable advanced or metastatic soft tissue sarcomas (STS) treated with trabectedin 1.5 mg/m2 once every 3 weeks at three reference centers in Italy. The effect of grade 3/4 elevations in alanine aminotransferase (ALT) or aspartate aminotransferase (AST) during the first two cycles and at any time during trabectedin treatment on progression-free su…

Malemedicine.medical_treatmentSoft Tissue NeoplasmsDioxoleKaplan-Meier EstimateGastroenterologyLiver Function TestsRetrospective StudieTetrahydroisoquinolinesTetrahydroisoquinolineTrabectedinMultidisciplinarybiologymedicine.diagnostic_testLiver Function TestSoft tissue sarcomaAlanine TransaminaseSarcomaMiddle AgedLiverFemaleSarcomamedicine.drugHumanAdultmedicine.medical_specialtyDioxolesdigestive systemArticleDisease-Free SurvivalDrug Administration ScheduleTransaminaseInternal medicinemedicineHumansAspartate AminotransferasesSoft Tissue NeoplasmAntineoplastic Agents AlkylatingRetrospective StudiesAgedChemotherapybusiness.industryRetrospective cohort studyAspartate Aminotransferasemedicine.diseasedigestive system diseasesSurgeryAlanine transaminasebiology.proteinbusinessLiver function testsAdult; Aged; Alanine Transaminase; Antineoplastic Agents Alkylating; Aspartate Aminotransferases; Dioxoles; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Liver; Liver Function Tests; Male; Middle Aged; Retrospective Studies; Sarcoma; Soft Tissue Neoplasms; Tetrahydroisoquinolines; MultidisciplinaryTrabectedin
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rTMS evidence of different delay and decision processes in a fronto-parietal neuronal network activated during spatial working memory.

2003

The existence of a specific and widely distributed network for spatial working memory (WM) in humans, involving the posterior parietal cortex and the prefrontal cortex, is supported by a number of neuroimaging studies. We used a repetitive transcranial magnetic stimulation (rTMS) approach to investigate the temporal dynamics and the reciprocal interactions of the different areas of the parieto-frontal network in normal subjects performing a spatial WM task, with the aim to compare neural activity of the different areas in the delay and decision phases of the task. Trains of rTMS at 25 Hz were delivered over the posterior parietal cortex (PPC), the premotor cortex (SFG) and the dorsolateral …

Malemedicine.medical_treatmentSpatial memoryParietal LoberTMSPrefrontal cortexBrain MappingrTMS Fronto-parietal neuronal network Spatial working memoryMotor CortexMagnetic Resonance ImagingFrontal Lobemedicine.anatomical_structureMemory Short-TermNeurologyPattern Recognition VisualSettore MED/26 - NeurologiaFemaleVisualPsychologypsychological phenomena and processesCognitive psychologyMagnetic Resonance Imaging; Magnetics; Orientation; Humans; Serial Learning; Prefrontal Cortex; Decision Making; Parietal Lobe; Nerve Net; Frontal Lobe; Motor Cortex; Brain Mapping; Memory Short-Term; Pattern Recognition Visual; Adult; Female; Male; Reaction TimeAdultCognitive NeuroscienceDecision MakingSpatial working memoryPosterior parietal cortexPrefrontal CortexPattern RecognitionSerial Learningbehavioral disciplines and activitiesNOPremotor cortexMagneticsNeuroimagingMemoryOrientationmental disordersBiological neural networkmedicineReaction TimeHumansFronto-parietal neuronal network; rTMS; Spatial working memory;Settore M-PSI/02 - Psicobiologia E Psicologia FisiologicaTranscranial magnetic stimulationDorsolateral prefrontal cortexFronto-parietal neuronal networkShort-Termnervous systemNerve NetNeuroscienceNeuroImage
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Transcranial magnetic resonance-guided focused ultrasound surgery at 1.5T: a technical note.

2019

Magnetic resonance-guided focused ultrasound is one of the emerging non-invasive technologies offering both image guidance and thermal monitoring. In recent years transcranial application of this technology is starting to impact heavily the neuroscience field. We present here the imaging protocol and the technological methods successfully used with a transcranial magnetic resonance-guided focused ultrasound system certified for clinical treatments of functional neurological disorders, integrated for the first time with a 1.5T magnetic resonance scanner. Compared to the body radiofrequency coil (the one commonly used with transcranial magnetic resonance-guided focused ultrasound system integ…

Maleminimally invasive surgical procedureComputer sciencebraininterventionalSignal-To-Noise RatioNeurosurgical ProcedureMagnetic Resonance Imaging InterventionalFocused ultrasoundNeurosurgical Procedures030218 nuclear medicine & medical imagingMagnetic resonance guided focused ultrasound surgery03 medical and health sciences0302 clinical medicinemedicinemagnetic resonance imagingHumansGeneral NeuroradiologyRadiology Nuclear Medicine and imagingImage guidanceAgedmedicine.diagnostic_testtomography X-ray computedMagnetic resonance scannerinterventional magnetic resonance imagingSettore MED/37 - NeuroradiologiaMagnetic resonance imagingTechnical noteGeneral MedicineSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)minimally invasive surgical proceduresstereotactic techniqueTreatment Outcomebrain; high-intensity focused ultrasound ablation; interventional magnetic resonance imaging; minimally invasive surgical procedures; stereotactic techniques; aged; female; high-intensity focused ultrasound ablation; humans; male; neurosurgical procedures; signal-to-noise ratio; tomography X-ray computed; treatment outcome; magnetic resonance imaging; interventionalElectromagnetic coilstereotactic techniquesHigh-Intensity Focused Ultrasound AblationFemaleNeurology (clinical)Settore MED/36 - Diagnostica Per Immagini E RadioterapiaTomography X-Ray Computed030217 neurology & neurosurgeryHumanRadiofrequency coilBiomedical engineeringThe neuroradiology journal
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