Search results for " Humans"

showing 10 items of 2466 documents

Clinical and Functional Characteristics of COPD Patients Across GOLD Classifications: Results of a Multicenter Observational Study.

2019

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease. The severity grading systems proposed by the Global initiative for Chronic Obstructive Lung Disease (GOLD) have changed over time. The aim of the study was to evaluate if the different GOLD classifications can capture the complexity of the disease by investigating the distribution of lung function and clinical parameters across the GOLD classification systems. This was an observational, retrospective, multicentre study. COPD patients were stratified according to the GOLD severity grading proposed in the 2007, and to the ABCD assessment tool present in the 2011, and 2017 versions of the initiative. Data from body plethy…

Pulmonary and Respiratory MedicineMaleChronic Obstructivemedicine.medical_specialtyphenotypeCopd patientsSettore MED/10 - Malattie dell'Apparato RespiratorioVital CapacitySocio-culturalePulmonary diseaseSeverity gradingDiseaseGOLD documentairflow obstructionurologic and male genital diseasesSeverity of Illness IndexPulmonary Disease03 medical and health sciencesLeukocyte CountPulmonary Disease Chronic Obstructive0302 clinical medicineRisk FactorsInternal medicineForced Expiratory VolumemedicineCOPDHumanseosinophil030212 general & internal medicineAgedRetrospective StudiesCOPDbusiness.industryairflow obstruction COPD eosinophil GOLD document phenotypeMiddle Agedmedicine.diseaseObstructive lung diseaserespiratory tract diseasesEosinophils030228 respiratory systemItalyairflow obstruction; COPD; eosinophil; GOLD document; phenotype; Aged; Eosinophils; Female; Forced Expiratory Volume; Humans; Inspiratory Capacity; Italy; Leukocyte Count; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Retrospective Studies; Risk Factors; Severity of Illness Index; Vital CapacityObservational studyFemalesense organsbusinessCOPD; GOLD document; airflow obstruction; eosinophil; phenotypeInspiratory CapacityCOPD
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Exploring the Relationship between Disease Awareness and Outcomes in Patients with Chronic Obstructive Pulmonary Disease

2020

<b><i>Background:</i></b> Disease awareness is a challenge in the management of chronic obstructive pulmonary disease (COPD). <b><i>Objectives:</i></b> The aim of this analysis was to explore the association between COPD optimal and suboptimal awareness, clinical parameters, and the following patient-reported outcomes: modified Medical Research Council (mMRC), Treatment Satisfaction Questionnaire (TSQM-9), COPD Assessment Test (CAT), Morisky Medication-Taking Adherence Scale (MMAS-4), and Brief Illness Perception Questionnaire (B-IPQ). <b><i>Methods:</i></b> This post hoc analysis of the SAT study included all enrolled …

Pulmonary and Respiratory MedicineMaleHealth Knowledge Attitudes Practicemedicine.medical_specialtyChronic ObstructiveHealth BehaviorClinical InvestigationsPulmonary diseaseSocio-culturaleDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness Indexchronic obstructive pulmonary diseaseTreatment satisfactionIllness perceptionsPulmonary DiseasePulmonary Disease Chronic ObstructiveDiagnostic Self EvaluationInternal medicineSurveys and QuestionnairesPost-hoc analysismedicineSettore MED/10HumansAdherence awareness chronic obstructive pulmonary disease patient-reported outcomesIn patientawarenessPatient Reported Outcome MeasuresAgedCOPDPracticebusiness.industryHealth KnowledgeSelf-Managementmedicine.diseaseSymptom Flare UpAdherence; Awareness; Chronic obstructive pulmonary disease; Patient-reported outcomes; Aged; Female; Health Knowledge Attitudes Practice; Humans; Italy; Male; Patient Reported Outcome Measures; Patient Satisfaction; Severity of Illness Index; Surveys and Questionnaires; Symptom Flare Up; Diagnostic Self Evaluation; Health Behavior; Pulmonary Disease Chronic Obstructive; Self-Management; Treatment Adherence and ComplianceTreatment Adherence and ComplianceItalyPatient SatisfactionAdherencepatient-reported outcomesAttitudesCopd assessment testFemalebusiness
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The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Three: A global synthesis

2013

This ISAAC Phase Three synthesis provides summarised information on the main findings of the study, regional tables and figures related to the prevalence and severity of current symptoms of asthma, rhinoconjunctivitis and eczema in the main regions of the world. The large number of surveyed children (≈1,200,000), the large number of centres (233) and countries (98) that participated in ISAAC Phase Three makes this study the most comprehensive survey of these diseases ever undertaken. Globally, the prevalence for current asthma, rhinoconjunctivitis and eczema in the 13-14-year age group was 14.1%, 14.6% and 7.3%, respectively. In the 6-7-year age group the prevalence for current asthma, rhin…

Pulmonary and Respiratory MedicineMalePediatricsmedicine.medical_specialtyAllergyAdolescentInternational CooperationImmunologyEczemaISAACSocioeconomic FactorSurveys and QuestionnairesEpidemiologymedicinePrevalenceHumansImmunology and AllergyPractice Patterns Physicians'ChildSocioeconomic statusChildrenRhinitiAsthmaAsthma; Children; Eczema; ISAAC; Rhinitis; Adolescent; Asthma; Child; Disease Progression; Female; Humans; International Cooperation; Male; Physician's Practice Patterns; Prevalence; Questionnaires; Socioeconomic Factors; Immunology and Allergybusiness.industryQuestionnaireDisease progressionGeneral Medicinemedicine.diseaseAsthmaSocioeconomic FactorsMulticenter studyEtiologyDisease ProgressionLocal environmentFemalePhysician's Practice PatternbusinessDemographyHuman
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Chronic obstructive pulmonary disease and neutrophil infiltration: role of cigarette smoke and cyclooxygenase products.

2010

Cigarette smoke is the main cause of chronic obstructive pulmonary disease (COPD), where it can contribute to the observed airway inflammation. PGE(2) is produced within human airways, and both pro- and anti-inflammatory activities have been reported. We quantitated PGE(2) concentrations in induced sputum supernatants from different groups of subjects and correlated the obtained values to neutrophil infiltration as well as to the expression of cyclooxygenase-2 (COX-2). Cigarette smoke extract (CSE) was used to evaluate the effect of smoking on COX-2 and PGE(2) receptor expression as well as on PGE(2) release in neutrophils and alveolar macrophages (AM) obtained from normal donors. The effec…

Pulmonary and Respiratory MedicineMalePhysiologyMacrophageNeutrophilsPulmonary diseaseTobacco smokeDinoprostonePulmonary Disease Chronic ObstructivePhysiology (medical)SmokemedicineCell AdhesionCigarette smokeCOPDHumansProtein IsoformsReceptors Prostaglandin EPGE(2)Respiratory systemcox-2AgedCOPDbiologybusiness.industryMacrophagesRespiratory diseaseNeutrophilSmokingProstaglandin-Endoperoxide SynthaseSputumProtein IsoformCell BiologyMiddle Agedmedicine.diseaseMacrophages; Prostaglandin-Endoperoxide Synthases; Humans; Aged; Protein Isoforms; Neutrophil Infiltration; Smoke; Smoking; Dinoprostone; Receptors Prostaglandin E; Neutrophils; Middle Aged; Sputum; Female; Male; Pulmonary Disease Chronic Obstructive; Cell Adhesionrespiratory tract diseasesNeutrophil InfiltrationProstaglandin-Endoperoxide SynthasesImmunologybiology.proteinFemaleCyclooxygenasebusinessInfiltration (medical)HumanAmerican journal of physiology. Lung cellular and molecular physiology
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Current Practices in the Management of Pulmonary Ground-Glass Opacities: A Survey of SICT Members

2018

Background Several gray areas and controversies exist concerning the management of pulmonary ground-glass opacities (GGOs), and there is a lack of consensus among clinicians on this topic. One of the main aims of the Italian Society of Thoracic Surgery is to promote education and research, so we decided to perform a survey on this topic to estimate current trends in practice in a large sample of thoracic surgeons. Methods A total of 160 thoracic surgeons responded, namely, completed our questionnaire (response rate, 53%; 160 of 302). The survey was composed of 36 questions divided into six subsections: (1) demographic characteristics of the respondents; (2) terminology and taxonomy; (3) rad…

Pulmonary and Respiratory MedicineMalemedicine.medical_specialtyLung NeoplasmsOutcome AssessmentAttitude of Health PersonnelComputed tomographyPractice Patterns030204 cardiovascular system & hematologyRisk AssessmentLung/diagnostic imaging Lung/pathology Lung Neoplasms/diagnostic imaging*Fluorodeoxyglucose positron emission tomography03 medical and health sciences0302 clinical medicineSettore MED/21 - CHIRURGIA TORACICAMedicalSurveys and QuestionnairesOutcome Assessment Health CaremedicineHumansPractice Patterns Physicians'TomographyLungSocieties MedicalSurgeonsPhysicians'medicine.diagnostic_testbusiness.industryGeneral surgeryConsensus conferenceThoracic SurgeryLarge sampleX-Ray ComputedHealth CareItalyCardiothoracic surgery030220 oncology & carcinogenesisHealth Care SurveysPositron-Emission TomographyCell lung-cancer Invasive adenocarcinoma Wedge resection In-situ Classification Association Tomography Lobectomy Diagnosis HistorySurgeryFemaleLung resectionCardiology and Cardiovascular MedicinebusinessSocietiesTomography X-Ray ComputedAttitude of Health Personnel; Female; Health Care Surveys; Humans; Italy; Lung; Lung Neoplasms; Male; Positron-Emission Tomography; Practice Patterns Physicians'; Risk Assessment; Societies Medical; Surgeons; Thoracic Surgery; Tomography X-Ray Computed; Outcome Assessment Health Care; Surveys and Questionnaires
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Maternal complications and procedures in pregnancy and at birth and wheezing phenotypes in children

2006

There is increasing interest in the potential influence of fetal and early life conditions on childhood wheezing.To investigate the associations between maternal complications and procedures in pregnancy and at birth and the risk of various wheezing phenotypes in young children.We studied 15,609 children, aged 6-7 yr, enrolled in a population-based study. Standardized questionnaires were completed by the children's mothers.Of the children, 9.5% (1,478) had transient early wheezing, 5.4% (884) had persistent wheezing, and 6.1% (948) had late-onset wheezing. Maternal hypertension or preeclampsia was associated with an increased risk of all three wheezing phenotypes (for transient early wheezi…

Pulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPopulationPerinatalCritical Care and Intensive Care Medicineasthma; perinatal; programmingPregnancyRisk FactorsIntensive careAsthma; Perinatal; Programming; Child; Female; Humans; Pregnancy; Respiratory Sounds; Risk Factors; Pregnancy Complications; Medicine (all); Pulmonary and Respiratory Medicine; Critical Care and Intensive Care MedicineMaternal hypertensionMedicineHumansRespiratory Sounds; Pregnancy Complications; Risk Factors; Humans; Child; Female; PregnancyRespiratory soundseducationChildAsthmaRespiratory SoundsPregnancyeducation.field_of_studymedicine.diagnostic_testbusiness.industryRisk FactorMedicine (all)Odds ratiomedicine.diseasePregnancy ComplicationAsthmaPregnancy ComplicationsProgrammingGestationFemaleRespiratory SoundbusinessHuman
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Factors that influence exhaled nitric oxide in Italian schoolchildren

2008

Conflicting results exist about the meaning of exhaled nitric oxide (eNO) in epidemiologic studies, mainly because of the numerous factors that may affect the measurement.To evaluate the role of the factors that influence eNO levels in a sample of schoolchildren with or without respiratory diseases. We studied 335 schoolchildren, ages 10 to 16 years, from 8 schools in Palermo, Italy. After a respiratory questionnaire was completed, spirometry, skin tests, and eNO measurements were performed.Among 335 children, 13.7% reported symptoms of bronchial asthma, 46.9% reported symptoms of rhinitis, and 39.4% were asymptomatic. The ratio of forced expiratory volume in 1 second to forced vital capaci…

Pulmonary and Respiratory MedicineSpirometryHypersensitivity ImmediateMalemedicine.medical_specialtyPediatricsVital capacityBreath TestAdolescentImmunologySex FactorNitric OxideAsymptomaticAtopySex FactorsInternal medicineSex Factors; Skin Tests; Exhalation; Humans; Asthma; Rhinitis; Child; Italy; Nitric Oxide; Cross-Sectional Studies; Spirometry; Allergens; Hypersensitivity Immediate; Adolescent; Breath Tests; Female; MalemedicineImmunology and AllergyHumansRespiratory systemChildSensitizationRhinitiAsthmaRhinitisSkin TestsCross-Sectional Studiemedicine.diagnostic_testSkin Testbusiness.industryAllergenAllergensmedicine.diseaseAsthmamedicine.anatomical_structureCross-Sectional StudiesBreath TestsItalyExhalationSpirometryExhaled nitric oxideFemalemedicine.symptombusinessHuman
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A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren

2011

Increased body weight may influence airway inflammatory mechanisms.To assess whether overweight-obesity (OW-O), evaluated as increased body mass index, is associated either with exhaled nitric oxide (eNO), a marker of airway inflammation, or with allergic sensitization in a large sample of children and adolescents.A cross-sectional, epidemiological study was performed on a population sample of schoolchildren evaluating 708 subjects (age 10-16 years; BMI 13-39 kg/m(2)) by respiratory health questionnaire, skin prick tests, spirometry, and eNO measure.Prevalence rates were: OW-O 16.4%, asthma ever (A) 11.9%, and rhinoconjunctivitis (RC) 14.8%. Asthma ever and allergic sensitization were signi…

Pulmonary and Respiratory MedicineSpirometryMaleObesity; Vital Capacity; Humans; Asthma; Child; Body Mass Index; Sicily; Forced Expiratory Volume; Nitric Oxide; Cross-Sectional Studies; Rhinitis Allergic Perennial; Logistic Models; Adolescent; Female; Male; PrevalenceVital capacitymedicine.medical_specialtyRhinitis Allergic PerennialLogistic ModelAdolescentImmunologyVital CapacityNitric OxideBody Mass IndexAllergic sensitizationAtopyFEV1/FVC ratioInternal medicineForced Expiratory VolumemedicinePrevalenceImmunology and AllergyHumansObesityRisk factorChildSicilyAsthmaCross-Sectional Studiemedicine.diagnostic_testbusiness.industrymedicine.diseaseAsthmarespiratory tract diseasesCross-Sectional StudiesLogistic ModelsAnesthesiaExhaled nitric oxideFemalebusinessHuman
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Alternative ways of expressing FEV1 and mortality in elderly people with and without COPD

2013

Expressing forced expiratory volume in 1 s (FEV1) as % predicted relies on the assumption of proportional variability and generalisability of prediction equations that may be unrealistic, especially for elderly people. We evaluated the prognostic implications of alternative ways of expressing FEV1. We enrolled 318 patients with chronic obstructive pulmonary disease (COPD) and 475 controls in the Salute Respiratoria nell'Anziano (SARA) study. The risk for 5-, 10- and 15-year mortality associated with FEV1 was studied by expressing FEV1 % pred, standardised by height cubed (FEV1 · Ht(-3)) and as a multiple of the sex-specific first percentile (FEV1 quotient (FEV1Q)). In the group with COPD, t…

Pulmonary and Respiratory MedicineSpirometryMalemedicine.medical_specialtyPediatricsPercentilePrognosiPulmonary diseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioRate ratioPulmonary Disease Chronic ObstructiveElderly populationInternal medicineForced Expiratory VolumeHumansMedicineElderly peopleRespiratory Function TestAgedCOPDmedicine.diagnostic_testbusiness.industryRespiratory Function Tests; Spirometry; Humans; Treatment Outcome; Prognosis; Case-Control Studies; Aged; Middle Aged; Forced Expiratory Volume; Male; Female; Pulmonary Disease Chronic ObstructiveCase-control studyrespiratory systemMiddle AgedPrognosismedicine.diseaseRespiratory Function Testsrespiratory tract diseasesTreatment OutcomeSpirometryCase-Control StudiesFemalebusinessCase-Control StudieHuman
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Why chronic obstructive pulmonary disease patients get so short of breath with limited activity

2013

equivalence despite the simplicity of MPT versus CPET as a surrogate to detect DH in COPD patients, by measuring the decrease in inspiratory capacity to reflect the increase in end-expiratory lung volume [3] . Lahaije et al. [2] have investigated whether DH as measured in the laboratory settings (CPET and MPT) reflects DH that is associated with dyspnea-limiting ADL. The authors conclude that both CPET and MPT can serve as a screening tool to identify patients who are susceptible to develop DH during ADL. In practice, MPT is simpler to obtain and is an inexpensive surrogate. However, sensitivity of MPT may not be optimal. When DH does not occur during CPET, it is unlikely to occur during AD…

Pulmonary and Respiratory MedicineSpirometrymedicine.medical_specialtyWeaknessSettore MED/10 - Malattie Dell'Apparato RespiratorioTachypneaPulmonary Disease Chronic ObstructiveActivities of Daily LivingmedicineHumansLung volumesIntensive care medicineDynamic hyperinflationCOPDLungmedicine.diagnostic_testbusiness.industryAirway obstructionmedicine.diseaserespiratory tract diseasesmedicine.anatomical_structureExercise Testmedicine.symptombusinessExercise Test; Humans; Activities of Daily Living; Pulmonary Disease Chronic ObstructiveHuman
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