Search results for " Humans"
showing 10 items of 2466 documents
Splenic Littoral Cell Hemangioendothelioma in a Patient With Crohn's Disease Previously Treated With Immunomodulators and Anti-TNF Agents: A Rare Tum…
2011
Th e risk of malignancy in Crohn ’ s disease (CD) has been well described. Moreover, immunomodulators, uch as azathioprine (AZA) and 6-mercaptopurine (6-MP), and biological agents, such as infl iximab and adalimumab, may promote carcinogenesis ( 1 – 3 ). Splenic littoral cell tumors are recently described tumors of vascular origin composed of endothelial cells, with typical microscopic and immunohistochemical features of splenic sinus lining cells ( 4 ). Clinical findings are not specific, and outcome is unpredictable but usually benign, although a few cases with a malignant behavior have been reported ( 5,6 ). We report a 58-year-old Caucasian man with a long history of ileocolonic CD.
El estatuto jurídico del honor en el Convenio Europeo de Derechos Humanos: de una restricción legítima de la libertad de expresión a un derecho human…
2016
En el presente artículo vamos a estudiar cuál ha sido la evolución en la concepción del honor por parte del Tribunal Europeo de Derechos Humanos y demás órganos del Consejo de Europa. Así pues, podremos observar cómo ha pasado de ser considerado de una simple restricción legítima a la libertad de expresión del artículo 10.2 CEDH, a un derecho humano autónomo, manifestación del derecho más amplio a la protección de la vida privada del 8 CEDH.
La jurisprudencia del TEDH sobre el 'interés público' como el elemento fundamental de la libertad de expresión
2016
A través del presente artículo, vamos a analizar la figura del interés público. De su existencia dependerá que al ejercicio de la libertad de expresión pueda beneficiarse del estatus de posición preferente frente a los derechos de la personalidad. In this article, we analyze the figure of public interest. Only if it exists, freedom of expression could benefit from preferred position status against the rights of personality.
Los límites jurídicos a la concesión de amnistías
2020
Dedico el presente trabajo a analizar los eventuales límites que existen en el Derecho internacional contemporáneo a las proclamaciones o concesiones por los Estados de amnistías totales o de alcance general en el contexto de la denominada justicia transicional.
Participación ciudadana e inmigración: consideraciones políticas y jurídicas
2019
RESUMEN. La participación ciudadana es el elemento clave en la labor de integración de las personas migrantes. La perspectiva política y la jurídica de esta cuestión se estudian en el presente trabajo para concluir que el derecho humano a la participación ciudadana es la base sobre la que edificar las democracias del siglo XXI, que no podrán mantener la estructura de ciudadanías de dos velocidades que forman su sociedad. La integración ha de ser lo más completa posible, y ello implica un mayor reconocimiento de derechos a los migrantes, fundamentalmente en el escenario de la participación ciudadana.
España y el Comité de Derechos Humanos
2020
El presente trabajo analiza la práctica del Comité de Derechos Humanos del Pacto internacional de derechos civiles y políticos sobre las comunicaciones individuales presentadas contra España, así como su incidencia en el Derecho interno español. The present paper analyses the Human Rights Committee's practice of the International Covenant on Civil and Political Rights concerning the individual communications submitted against Spain, as well as its influence in Spanish domestic law.
Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a …
2022
Invasive mechanical ventilation; COVID-19; Critical care Ventilación mecánica invasiva; COVID-19; Cuidado crítico Ventilació mecànica invasiva; COVID-19; Atenció crítica Background Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods This is a multin…
Identification and expansion of human colon-cancer-initiating cells
2007
Colon carcinoma is the second most common cause of death from cancer. The isolation and characterization of tumorigenic colon cancer cells may help to devise novel diagnostic and therapeutic procedures. Although there is increasing evidence that a rare population of undifferentiated cells is responsible for tumour formation and maintenance, this has not been explored for colorectal cancer. Here, we show that tumorigenic cells in colon cancer are included in the high-density CD133+ population, which accounts for about 2.5% of the tumour cells. Subcutaneous injection of colon cancer CD133+ cells readily reproduced the original tumour in immunodeficient mice, whereas CD133- cells did not form …
Global diversity in the TAS2R38 bitter taste receptor: revisiting a classic evolutionary PROPosal
2016
AbstractThe ability to taste phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) is a polymorphic trait mediated by the TAS2R38 bitter taste receptor gene. It has long been hypothesized that global genetic diversity at this locus evolved under pervasive pressures from balancing natural selection. However, recent high-resolution population genetic studies of TAS2Rs suggest that demographic events have played a critical role in the evolution of these genes. We here utilized the largest TAS2R38 database yet analyzed, consisting of 5,589 individuals from 105 populations, to examine natural selection, haplotype frequencies and linkage disequilibrium to estimate the effects of both selectio…
Cabbage and fermented vegetables: from death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19
2021
International audience; Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance …