Search results for " Humans"

showing 10 items of 2466 documents

To do or not to do? plasma exchange and timing of steroid administration in progressive multifocal leukoencephalopathy

2016

OBJECTIVE: To retrospectively analyze the effect of plasma exchange (PLEX; yes = PLEX+ , no = PLEX- ) and steroids administration timing (prophylactically [proST] or therapeutically [therST]) on the longitudinal clinical course of patients with natalizumab-related progressive multifocal leukoencephalopathy (PML) and full-blown immune reconstitution inflammatory syndrome (PML-IRIS). METHODS: Clinical and radiological data of 42 Italian patients with PML were analyzed. Patient's data are available until 12 months after PML diagnosis. PLEX and steroids treatment as time-dependent covariates were entered in: (1) a Cox model to investigate their impact on full-blown PML-IRIS latency; (2) an anal…

AdultMaleAdult; Databases Factual; Disability Evaluation; Female; Humans; Immune Reconstitution Inflammatory Syndrome; Leukoencephalopathy Progressive Multifocal; Male; Plasma Exchange; Retrospective Studies; Steroids; Young Adult; Neurology; Neurology (clinical)Adult; Databases Factual; Disability Evaluation; Female; Humans; Immune Reconstitution Inflammatory Syndrome; Leukoencephalopathy Progressive Multifocal; Male; Plasma Exchange; Retrospective Studies; Steroids; Young AdultDatabases FactualPlasma ExchangeLeukoencephalopathy Progressive MultifocalProgressive MultifocalDatabasesDisability EvaluationYoung AdultNeurologyLeukoencephalopathyImmune Reconstitution Inflammatory SyndromeRetrospective StudieHumansSteroidsFemaleSettore MED/26 - NeurologiaNeurology (clinical)SteroidFactualRetrospective StudiesHuman
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Affective temperaments in general population: A review and combined analysis from national studies

2010

Abstract Background The aim of this study was to investigate the characteristics of affective temperaments in general non-clinical population in different countries Method We performed a detailed search of published studies (one unpublished) investigating affective temperaments in non-clinical populations by administering the Temperament Evaluation of Memphis, Paris and San Diego Auto-questionnaire (TEMPS-A) in its 110-items version. We have included a total of six studies published from different countries (Argentina, Germany, Hungary, Korea, Lebanon, and Portugal) and one unpublished with preliminary data from Spain. We analyzed the combined data from the collected studies. Results We fou…

AdultMaleAffective temperamentsmedicine.medical_specialtyAdolescentmedia_common.quotation_subjectPopulationArgentinaPersonality AssessmentAffect (psychology)Young AdultSex FactorsSex factorsRepublic of KoreamedicineGender differencesHumansPersonalityLebanonYoung adultTemperamentPsychiatryeducationmedia_commoneducation.field_of_studyAffective temperamentGeneral populationMiddle AgedEuropeAffectPsychiatry and Mental healthClinical PsychologyTEMPS-AHomogeneousAffective temperament; Gender differences; General population; Nonclinical population; TEMPS-A; Adolescent; Adult; Argentina; Europe; Female; Humans; Lebanon; Male; Middle Aged; Personality Assessment; Republic of Korea; Sex Factors; Temperament; Young Adult; Affect; Personality; Clinical Psychology; Psychiatry and Mental HealthFemaleTemperamentNonclinical populationPsychologyPersonalityClinical psychologyJournal of Affective Disorders
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Consensus Document on substitution therapy with DHEA in the elderly

2006

AdultMaleAgingmedicine.medical_specialtyHormone Replacement TherapyAlternative medicineSocio-culturaleAdult; Aged; Aged 80 and over; Aging; Atherosclerosis; Bone Diseases Metabolic; Cognition Disorders; Dehydroepiandrosterone; Female; Hormone Replacement Therapy; Humans; Italy; Male; Middle Aged80 and overAdrenal insufficiencyHumansMedicineSubstitution therapyIntensive care medicineAgedAged 80 and overbusiness.industryGeriatrics gerontologyDehydroepiandrosteroneMiddle AgedAtherosclerosismedicine.diseaseConsensus Document elderly adrenal insufficiency adrenopause DHEA DHEAS DHEA substitution therapyBone Diseases MetabolicItalyPhysical therapyFemaleMetabolicBone DiseasesGeriatrics and GerontologyCognition DisordersbusinessAging Clinical and Experimental Research
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Population-level risks of alcohol consumption by amount, geography, age, sex, and year: a systematic analysis for the Global Burden of Disease Study …

2022

Background: The health risks associated with moderate alcohol consumption continue to be debated. Small amounts of alcohol might lower the risk of some health outcomes but increase the risk of others, suggesting that the overall risk depends, in part, on background disease rates, which vary by region, age, sex, and year. Methods: For this analysis, we constructed burden-weighted dose-response relative risk curves across 22 health outcomes to estimate the theoretical minimum risk exposure level (TMREL) and non-drinker equivalence (NDE), the consumption level at which the health risk is equivalent to that of a non-drinker, using disease rates from the Global Burden of Diseases, Injuries, and …

AdultMaleAlcohol DrinkingCONTROL POLICIESadult; Alcohol Drinking; Child Preschool; Female; Geography; Global Burden of Disease; Global Health; Humans; Male; Middle Aged; Quality-Adjusted Life Years; Risk FactorsNDASALL-CAUSEGUIDELINESGlobal HealthGBD 2020 Alcohol CollaboratorsGlobal Burden of DiseaseCOST-EFFECTIVENESSMedicine General & InternalDRINKINGSDG 3 - Good Health and Well-beingRA0421Risk FactorsGeneral & Internal MedicineQuality-Adjusted Life YearRA0421 Public health. Hygiene. Preventive MedicineDRINKERSHumansChildPreschool11 Medical and Health SciencesMETAANALYSISMCCScience & Technologyglobal burden of diseaseGeographyRisk FactoradultGeneral MedicineMiddle AgedCANCERalcohol drinkingACChild Preschool3121 General medicine internal medicine and other clinical medicineFemaleQuality-Adjusted Life YearsREDUCED MORTALITYLife Sciences & Biomedicinealcohol drinking; global burden of disease; adultHuman
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Functional anatomy of motor recovery after early brain damage

2004

Functional magnetic resonance imaging and transcranial magnetic stimulation were used to examine a 34 year-old right-handed patient, who, at the age of 6 years, had experienced sudden right hemiplegia, seizures, and stupor during a bout of measles encephalitis, followed by incomplete distal right motor recovery. Morphological MRI showed massive unilateral enlargement of the left ventricle, associated with extreme thinning of the white and gray matter, with partial preservation of the pyramidal tract. Functional MRI and transcranial magnetic stimulation revealed reorganization of the motor cortices, and integrity of the corticospinal pathway, respectively. Our findings indicate that complete…

AdultMaleCORTEXmedicine.medical_treatmentCHILDHOODAdult; Brain Damage Chronic; Humans; Magnetic Resonance Imaging; Magnetoencephalography; Male; Paresis; Psychomotor Performance; Subacute Sclerosing PanencephalitisCHILDRENBrain damageArts and Humanities (miscellaneous)Magnetic Resonance Imaging; Magnetoencephalography; Paresis; Humans; Brain Damage Chronic; Adult; Psychomotor Performance; Subacute Sclerosing Panencephalitis; MalemedicineHumansBrain DamagePLASTICITYChronicPyramidal tractsmedicine.diagnostic_testSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaStuporMagnetoencephalographyAnatomymedicine.diseaseMagnetic Resonance ImagingTranscranial magnetic stimulationParesismedicine.anatomical_structureVentricleBrain Damage ChronicMotor recoverySettore MED/26 - NeurologiaNeurology (clinical)Subacute Sclerosing Panencephalitismedicine.symptomFunctional magnetic resonance imagingPsychologyNeuroscienceEncephalitisSTROKEPsychomotor PerformanceMRI
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Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer.

2011

Tobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer and significant variation is observed in UADT cancer rates across Europe. We have estimated the proportion of UADT cancer burden explained by tobacco and alcohol and how this varies with the incidence rates across Europe, cancer sub-site, gender and age. This should help estimate the minimum residual burden of other risk factors to UADT cancer, including human papillomavirus. We analysed 1981 UADT cancer cases and 1993 controls from the ARCAGE multicentre study. We estimated the population attributable risk (PAR) of tobacco alone, alcohol alone and their joint effect. Tobacco and alcohol together explaine…

AdultMaleCancer Researchmedicine.medical_specialtyAlcohol DrinkingEsophageal NeoplasmsAlcoholchemistry.chemical_compoundRisk FactorsTobaccomedicineHumansPopulation attributable riskGynecologyMouth neoplasmbusiness.industryIncidenceMedicine (all)Incidence (epidemiology)SmokingCase-control studyCancerAlcohol; ARCAGE study; Population attributable risk; Tobacco; Upper aerodigestive tract cancer; Adult; Alcohol Drinking; Case-Control Studies; Esophageal Neoplasms; Europe; Female; Humans; Incidence; Male; Middle Aged; Mouth Neoplasms; Otorhinolaryngologic Neoplasms; Risk Factors; Smoking; Oral Surgery; Medicine (all); Oncology; Cancer ResearchMiddle Agedmedicine.diseaseUpper aerodigestive tract cancerARCAGE studyEuropeOtorhinolaryngologic NeoplasmsUpper aerodigestive tractOncologychemistryCase-Control StudiesAttributable riskFemaleMouth NeoplasmsUpper aerodigestive tract cancer; ARCAGE study; Population attributable risk; Tobacco; AlcoholOral SurgeryAlcoholbusinessOropharyngeal CancersDemography
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Does access to care play a role in liver cancer survival? The ten-year (2006–2015) experience from a population-based cancer registry in Southern Ita…

2021

Abstract Background Hepatocellular carcinoma (HCC) is the most frequent primary invasive cancer of the liver. During the last decade, the epidemiology of HCC has been continuously changing in developed countries, due to more effective primary prevention and to successful treatment of virus-related liver diseases. The study aims to examine survival by level of access to care in patients with HCC, for all patients combined and by age. Methods We included 2018 adult patients (15–99 years) diagnosed with a primary liver tumour, registered in the Palermo Province Cancer Registry during 2006–2015, and followed-up to 30 October 2019. We obtained a proxy measure of access to care by linking each re…

AdultMaleCancer Researchmedicine.medical_specialtyCarcinoma HepatocellularAdolescentContext (language use)access to care cancer registries liver cancer public health survival Adolescent AdultAge Distribution Aged Aged 80 and over Carcinoma Hepatocellular Decision Making Organizational Decision Support Techniques Female Follow-Up Studies Health Services Accessibility Health Services Needs and Demand Humans Italy Liver Neoplasms Male Middle Aged Registries Survival Analysis Young AdultSettore MED/42 - Igiene Generale E Applicatalcsh:RC254-282survivalHealth Services AccessibilityDecision Support Techniquesliver cancerYoung AdultAge DistributionInternal medicineHealth careEpidemiologyGeneticsmedicineHumansRegistriesDecision Making OrganizationalAgedAged 80 and overaccess to careHealth Services Needs and Demandbusiness.industryPublic healthLiver Neoplasmspublic healthMiddle Agedlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensmedicine.diseaseSurvival AnalysisCancer registryItalyOncologycancer registriesHepatocellular carcinomaAmbulatoryFemaleLiver cancerbusinessFollow-Up StudiesResearch ArticleBMC Cancer
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Comparison of Different Nodal Staging in Patients With Locally Advanced Mid-low Rectal Cancer After Long-term Neoadjuvant Chemoradiation Therapy.

2019

Background/Aim: The aim of this study was to compare the ability of different lymph nodal staging systems to predict cancer recurrence in a multicenter European series of patients who underwent proctectomy after neoadjuvant chemoradiotherapy for locally advanced rectal cancer. Patients and Methods: Data on 170 consecutive patients undergoing proctectomy after neoadjuvant therapy for cT3-4 or cN+ rectal adenocarcinoma were retrieved from the European MRI and Rectal Cancer Surgery database. The prognostic role of the number of retrieved and examined nodes, nodal ratio, and log odds of positive lymph nodes (LODDS) was analyzed and compared by receiver operating characteristic curves, Pearson t…

AdultMaleCancer Researchmedicine.medical_specialtyMultivariate analysisColorectal cancerDisease-free survivalmedicine.medical_treatmentLODDSLocally advancedAdenocarcinomaDisease-Free SurvivalLog odds of positive lymph nodeRectal AdenocarcinomaMedicineHumansRectal cancerLog odds of positive lymph nodesNeoadjuvant therapyAgedNeoplasm StagingAged 80 and overReceiver operating characteristicddc:617business.industryRectal NeoplasmsHazard ratioGeneral MedicineNodal ratioChemoradiotherapyMiddle Agedmedicine.diseasePrognosisConfidence intervalNeoadjuvant TherapyOncologydisease-free survival; lodds; log odds of positive lymph nodes; neoadjuvant therapy; nodal ratio; rectal cancer; adenocarcinoma; adult; aged; aged 80 and over; disease-free survival; female; humans; lymph nodes; male; middle aged; neoplasm recurrence Local; Neoplasm Staging; Prognosis; Rectal Neoplasms; Chemoradiotherapy; Neoadjuvant TherapyNeoadjuvant therapyFemaleRadiologyLymph NodesNeoplasm Recurrence LocalbusinessAnticancer research
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Repetitive TMS of cerebellum interferes with millisecond time processing

2007

Time processing is important in several cognitive and motor functions, but it is still unclear how the human brain perceives time intervals of different durations. Processing of time in millisecond and second intervals may depend on different neural networks and there is now considerable evidence to suggest that these intervals are possibly measured by independent brain mechanisms. Using repetitive transcranial magnetic stimulation (rTMS), we determined that the cerebellum is essential in explicit temporal processing of millisecond time intervals. In the first experiment, subjects' performance in a time reproduction task of short (400-600 ms) and long (1,600-2,400 ms) intervals, were evalua…

AdultMaleCerebellumData InterpretationTime perception; Timing; Transcranial magnetic stimulation; rTMS; Cerebellummedicine.medical_treatmentPrefrontal CortexStimulationTime perception Timing Transcranial magnetic stimulation rTMS CerebellumMagnetic Resonance Imaging; Humans; Adult; Cerebellum; Time Perception; Data Interpretation Statistical; Prefrontal Cortex; Transcranial Magnetic Stimulation; Male; Functional Laterality; FemaleFunctional LateralityNOCerebellum; rTMS; Time perception; Timing; Transcranial magnetic stimulation;CerebellumrTMSmedicineHumansTimingPrefrontal cortexMillisecondNeuroscience (all)Settore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologyGeneral NeuroscienceMemoriaHuman brainTime perceptionStatisticalMagnetic Resonance ImagingTranscranial Magnetic StimulationTranscranial magnetic stimulationmedicine.anatomical_structurenervous systemData Interpretation StatisticalTime PerceptionFemaleSettore MED/26 - NeurologiaPsychologyNeuroscienceHuman
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Increased facilitation of the primary motor cortex following 1 Hz repetitive transcranial magnetic stimulation of the contralateral cerebellum in nor…

2005

Connections between the cerebellum and the contralateral motor cortex are dense and important, but their physiological significance is difficult to measure in humans. We have studied a group of 10 healthy subjects to test whether a modulation of the excitability of the left cerebellum can affect the excitability of the contralateral motor cortex. We used repetitive transcranial magnetic stimulation (rTMS) at 1 Hz frequency to transiently depress the excitability of the left cerebellar cortex and paired-pulse TMS testing of intracortical inhibition (ICI) and intracortical facilitation (ICF) to probe the excitability of cortico-cortical connections in the right motor cortex. The cortical sile…

AdultMaleCerebellumTMS Cerebellum Motor cortex Motor evoked potentialsmedicine.medical_treatmentbehavioral disciplines and activitiesSynaptic TransmissionMotor evoked potentialsFunctional LateralityNOCerebellar CortexPurkinje CellsCerebellum; Motor cortex; Motor evoked potentials; TMS;Reference ValuesCerebellumNeural PathwaysmedicineReaction TimeHumansEvoked PotentialsSettore M-PSI/02 - Psicobiologia E Psicologia Fisiologicamusculoskeletal neural and ocular physiologyGeneral NeuroscienceInterstimulus intervalMotor CortexNeural InhibitionEvoked Potentials MotorTranscranial Magnetic StimulationElectric StimulationTranscranial magnetic stimulationElectrophysiologyReference Values; Humans; Cerebellum; Neural Inhibition; Electric Stimulation; Cerebellar Cortex; Purkinje Cells; Motor Cortex; Evoked Potentials Motor; Adult; Neural Pathways; Transcranial Magnetic Stimulation; Synaptic Transmission; Female; Functional Laterality; Male; Reaction Time; Cerebellar Nucleimedicine.anatomical_structurenervous systemMotorCerebellar NucleiTMSCerebellar cortexSilent periodSettore MED/26 - NeurologiaFemalePrimary motor cortexPsychologyNeurosciencepsychological phenomena and processesMotor cortexNeuroscience letters
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