Search results for " Humans"

showing 10 items of 2466 documents

Effectiveness of high dose sublingual immunotherapy to induce a stepdown of seasonal asthma: a pilot study

2009

There is ample evidence to support the efficacy of sublingual immunotherapy (SLIT) on allergic rhinitis, while there is less solid data regarding asthma. We evaluated the effects of a high dose birch SLIT on birch-induced rhinitis and asthma in a controlled study.This double-blind, placebo-controlled, randomised, single centre trial on SLIT with birch pollen allergen extract (Stallergenes, Antony, France) included 24 patients presenting severe rhinitis and slight to moderate asthma, 14 actively and 10 placebo treated. SLIT was performed by a pre-coseasonal protocol, and was repeated for 2 years. The study plan included a selection visit, a visit at the start of the first and the second trea…

AdultMalemedicine.medical_specialtyModerate asthmaDouble-Blind Method; Humans; Immunotherapy; Seasons; Adult; Asthma; Placebos; Pilot Projects; Middle Aged; Male; Female; Drug Administration RoutesPilot ProjectsPlacebolaw.inventionPlacebosSeasonal asthmaRandomized controlled trialDouble-Blind MethodlawInternal medicinemedicineHumansSublingual immunotherapyPilot ProjectPlaceboAsthmabusiness.industryDrug Administration RoutesGeneral MedicineMiddle Agedmedicine.diseaseSlitAsthmaSurgerySingle centreFemaleSeasonsImmunotherapySeasonSLIT asthma allergybusinessHuman
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"Baseline physical functioning status of metastatic colorectal cancer patients predicts the overall survival but not the activity of a front-line oxa…

2010

BACKGROUND: No differences in response rate (RR), progression-free survival (PFS), overall survival (OS) and quality of life (QoL) were seen in patients randomly treated with biweekly oxaliplatin plus either fluorouracil/folinic acid or capecitabine. METHODS: We investigated the independent effect of baseline clinical characteristics and physical functioning (PF) domain on RR, PFS, and OS in 310 patients who completed the EORTC QLQ-C30 questionnaire. Multivariate analyses stratified by treatment were performed. An exploratory analysis was done by grouping patients with a PF score superior or equal to the highest quartile (n = 111), included between the highest and the lowest quartiles (n = …

AdultMalemedicine.medical_specialtyMultivariate analysisColorectal cancerSettore MED/06 - Oncologia MedicaKaplan-Meier EstimateGastroenterologyDisease-Free SurvivalCapecitabineTreatment Outcome; Prognosis; Aged 80 and over; Male; Retrospective Studies; Randomized Controlled Trials as Topic; Middle Aged; Kaplan-Meier Estimate; Colorectal Neoplasms; Female; Disease-Free Survival; Humans; Quality of Life; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials Phase III as Topic; Aged; Adult; Health Status Indicators; Multicenter Studies as TopicFolinic acidQuality of lifeInternal medicineAntineoplastic Combined Chemotherapy Protocols80 and overmedicineOverall survivalHealth Status IndicatorsHumansMulticenter Studies as TopicClinical TrialsRadiology Nuclear Medicine and imagingneoplasmsmetastatic colorectal canceroxaliplatin physical functioning statusAgedRandomized Controlled Trials as TopicRetrospective StudiesAged 80 and overbusiness.industryHematologyGeneral MedicineMiddle AgedPrognosismedicine.diseaseSurgeryOxaliplatinPhase III as TopicTreatment OutcomeClinical Trials Phase III as TopicOncologyQuartileQuality of LifeFemaleColorectal Neoplasmsbusinessmedicine.drug
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Laparoscopic ileocecal resection in acute and chronic presentations of Crohn's disease. A single center experience

2017

Introduction The terminal ileum is the most involved tract in Crohn's disease. The obstruction in this location is the most frequent complication. Acute or chronic presentations can occur. Surgery finds a role in the management of chronic strictures and in acute clinical presentations with complications not improving with conservative therapy. Patients and methods We investigate the outcome of patients with obstruction of the ileo-cecal bowel tract laparoscopically managed. It was analyzed the average operative time (OT), the conversion rate and the occurrence of re-operation due to surgical complications. Results 21 patients underwent an ileocecal resection for complicated Crohn's disease …

AdultMalemedicine.medical_specialtyOperative TimeAnastomotic LeakAnastomosisClinical PracticeHospitals University03 medical and health sciencesIleocecal valve0302 clinical medicineCrohn DiseaseRisk FactorsRetrospective StudiemedicineHumansHemoperitoneumLaparoscopyRetrospective StudiesAcute Disease; Adult; Anastomosis Surgical; Anastomotic Leak; Chronic Disease; Conversion to Open Surgery; Crohn Disease; Female; Hospitals University; Humans; Ileal Diseases; Ileocecal Valve; Intestinal Obstruction; Length of Stay; Male; Operative Time; Retrospective Studies; Risk Factors; Treatment Outcome; LaparoscopyCrohn's diseaseIleocecal Valvemedicine.diagnostic_testbusiness.industryIleal DiseasesGeneral surgeryMortality rateRisk FactorAnastomosis SurgicalRetrospective cohort studyLength of Staymedicine.diseaseConversion to Open SurgerySurgerymedicine.anatomical_structureTreatment Outcome030220 oncology & carcinogenesisAcute DiseaseChronic DiseaseIleal Disease030211 gastroenterology & hepatologyFemaleLaparoscopymedicine.symptombusinessComplicationIntestinal ObstructionHuman
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Optokinetic stimulation affects temporal estimation in healthy humans

2007

The representation of time and space are closely linked in the cognitive system. Optokinetic stimulation modulates spatial attention in healthy subjects and patients with spatial neglect. In order to evaluate whether optokinetic stimulation could influence time perception, a group of healthy subjects performed "time-comparison" tasks of sub- and supra-second intervals before and after leftward or rightward optokinetic stimulation. Subjective time perception was biased by the direction of optokinetic stimulation. Rightward optokinetic stimulation induced an overestimation of time perception compared with baseline and leftward optokinetic stimulation. These results indicate a directional bias…

AdultMalemedicine.medical_specialtyOptokineticgenetic structuresPhotic StimulationCognitive Neurosciencemedia_common.quotation_subjectSpatial abilitySpaceExperimental and Cognitive PsychologyStimulationNystagmusAudiologyAnalysis of Variance; Perceptual Distortion; Humans; Time Perception; Psychophysics; Photic Stimulation; Adult; Cues; Space Perception; Nystagmus Optokinetic; Attention; Female; Functional Laterality; MaleFunctional LateralityTimeNystagmusArts and Humanities (miscellaneous)Optokinetic stimulation; Perception; Space; Time; Adult; Analysis of Variance; Attention; Cues; Female; Functional Laterality; Humans; Male; Nystagmus Optokinetic; Psychophysics; Perceptual Distortion; Photic Stimulation; Space Perception; Time Perception; Cognitive Neuroscience; Experimental and Cognitive Psychology; Neuropsychology and Physiological PsychologyPerceptionDevelopmental and Educational PsychologymedicinePsychophysicsPsychophysicsHumansAttentionNystagmus Optokineticmedia_commonAnalysis of VariancePerceptual DistortionSettore M-PSI/02 - Psicobiologia E Psicologia FisiologicaCognitionSpace TimePerception Optokinetic stimulationTime perceptionNeuropsychology and Physiological PsychologySpace PerceptionTime PerceptionPerceptionFemaleSettore MED/26 - Neurologiamedicine.symptomCuesOptokinetic stimulationPsychologyPhotic StimulationCognitive psychology
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Translation and Testing of the Italian Version of FAMCARE-2: Measuring Family Caregivers' Satisfaction With Palliative Care.

2017

Family satisfaction is an important outcome of palliative care and is a critical measure for health care professionals to address when assessing quality of care. The FAMCARE-2 is a widely used measure of family satisfaction with the health care received by both patient and family in palliative care. In this study, a team of Italian researchers culturally adapted the FAMCARE-2 to the Italian language and psychometrically tested the instrument by measuring satisfaction of 185 family caregivers of patients admitted into two palliative care services. FAMCARE-2 showed excellent levels of internal consistency (Cronbach’s α coefficient = .96) and test–retest reliability ( r = .98, p < .01). Th…

AdultMalemedicine.medical_specialtyPalliative carePsychometricsPsychometricspsychometricFamily satisfactionPersonal Satisfaction03 medical and health sciences0302 clinical medicineNursingCronbach's alphaSurveys and QuestionnairesHealth care80 and overmedicineHumansFamilyTranslations030212 general & internal medicinefamily caregiverAgedCommunity and Home CareAged 80 and overFamily caregiversbusiness.industryPalliative CareReproducibility of Resultssatisfaction with careMiddle AgedSettore MED/45 - Scienze Infermieristiche Generali Cliniche E PediatricheConfirmatory factor analysisCaregiversItalyPatient Satisfaction030220 oncology & carcinogenesisScale (social sciences)Family medicinesurveys and questionnaireFemaleFamily Practicebusinessitalian translation; family caregivers; palliative care; psychometric development; satisfaction with care; adult; aged; aged 80 and over; caregivers; family; female; humans; italy; male; middle aged; palliative care; patient satisfaction; psychometrics; reproducibility of results; surveys and questionnaires; translations; personal satisfactionitalian translationpsychometric developmentJournal of family nursing
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Inflammatory Bowel Disease Phenotype as Risk Factor for Cancer in a Prospective Multicentre Nested Case-Control IG-IBD Study

2016

Background and Aims: Cancer risk in inflammatory bowel disease [IBD] is still debated. In a prospective, multicentre, nested case-control study, we aimed to characterise incident cases of cancer in IBD. The role of immunomodulators vs clinical characteristics of IBD as risk factors for cancer was also investigated. Materials and Methods: From January 2012 to December 2014, each IBD patient with incident cancer was matched with two IBD patients without cancer for: IBD type, gender, and age. Risk factors were assessed by multivariate regression analysis. Results: IBD patients considered numbered 44619: 21953 Crohn’s disease \[CD], 22666 ulcerative colitis [UC]. Cancer occurred in 174 patients…

AdultMalemedicine.medical_specialtyPancolitisAdolescentColorectal cancerphenotypeSettore MED/12 - GASTROENTEROLOGIAcancer riskInflammatory bowel disease; cancer risk; phenotype; Adolescent; Adult; Aged; Aged 80 and over; Case-Control Studies; Female; Follow-Up Studies; Humans; Immunologic Factors; Incidence; Inflammatory Bowel Diseases; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasms; Prospective Studies; Risk Factors; Young Adult; PhenotypeGastroenterologyInflammatory bowel diseaseInflammatory bowel disease03 medical and health sciencesYoung Adult0302 clinical medicineRisk FactorsInternal medicineNeoplasms80 and overmedicineHumansImmunologic FactorsProspective StudiesRisk factorProspective cohort studyAgedAged 80 and overbusiness.industryIncidenceSettore MED/09 - MEDICINA INTERNAGastroenterologyCancerGeneral MedicineMiddle Agedmedicine.diseaseInflammatory Bowel DiseasesUlcerative colitisLogistic Models030220 oncology & carcinogenesisCase-Control StudiesNested case-control studyMultivariate Analysis030211 gastroenterology & hepatologyFemalemedicine.symptombusinessInflammatory bowel disease; cancer risk; phenotypeFollow-Up Studies
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How many parkinsonian patients are suitable candidates for deep brain stimulation of subthalamic nucleus? Results of a questionnaire.

2008

We used a CAPSIT-based questionnaire to estimate the percentage of parkinsonian patients suitable for subthalamic nucleus (STN) deep brain stimulation (DBS) in a movement disorders clinic. We found that out of 641 consecutive PD patients only 1.6% fulfilled strict STN-DBS criteria. When we applied more flexible criteria, the percentage of eligibility increased to 4.5%. Most patients (60%) were ineligible because they did not satisfy multiple questionnaire items. Items related to disease severity were responsible for the largest number of exclusions. This knowledge will help make decisions on resource allocation in centres wishing to start DBS surgery.

AdultMalemedicine.medical_specialtyParkinson's diseaseMovement disordersNeurologyDeep brain stimulationDeep Brain Stimulationmedicine.medical_treatmentParkinson Desease Deep Brain StimulationAudiologybehavioral disciplines and activitiesDisease severityParkinsonian DisordersSubthalamic NucleusSurveys and QuestionnairesmedicineHumansAgedChi-Square Distributionbusiness.industryPatient SelectionMiddle Agedmedicine.diseasenervous system diseasesSubthalamic nucleussurgical procedures operativenervous systemNeurologyCAPSIT; Parkinson's disease; Questionnaire; STN DBS; Adult; Aged; Chi-Square Distribution; Deep Brain Stimulation; Female; Humans; Male; Middle Aged; Parkinsonian Disorders; Subthalamic Nucleus; Surveys and Questionnaires; Patient Selection; Aging; Neurology (clinical); NeurologyPhysical therapyFemaleSettore MED/26 - NeurologiaNeurology (clinical)medicine.symptomGeriatrics and GerontologyPsychologybusinesstherapeuticsNeuroscienceNeurology; Geriatrics and Gerontology; Neurology (clinical)
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Oral self-injuries: clinical findings in a series of 19 patients

2015

Objectives: Self-injury (SI) is defined as a behavioral disturbance consisting of a deliberate harm to one’s own body without suicidal intent, it is not uncommon and ranges in severity from simple nail-biting to more extreme forms of self-mutilation. The head neck region may be the target of such lesions. SI is associated with several medical conditions, of which it can represent the first clinical sign. Aim of this paper is to describe a series of oral SI, giving special emphasis to the clinical findings, etiology and the management of lesions. Material and Methods: A total of 19 patients with oral SI were prospectively examined; attention was paid to the occurrence and characterization of…

AdultMalemedicine.medical_specialtyPediatricsAdolescentPoison controlOdontologíaDiseaseLesionYoung AdultInjury preventionmedicineHumansMedical historyAdolescent; Adult; Aged; Aged 80 and over; Child; Female; Humans; Male; Middle Aged; Mouth; Prospective Studies; Wounds and Injuries; Young Adult; Self-Injurious BehaviorProspective StudiesYoung adultProspective cohort studyChildGeneral DentistryAgedAged 80 and overMouthOral Medicine and Pathologybusiness.industryResearchWounds and InjurieMiddle Aged:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludSurgeryProspective StudieOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASEtiologyWounds and InjuriesSurgeryFemalemedicine.symptombusinessSelf-Injurious BehaviorHuman
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Influenza vaccination coverage among medical residents: An Italian multicenter survey

2014

Although influenza vaccination is recognized to be safe and effective, recent studies have confirmed that immunization coverage among health care workers remain generally low, especially among medical residents (MRs). Aim of the present multicenter study was to investigate attitudes and determinants associated with acceptance of influenza vaccination among Italian MRs. A survey was performed in 2012 on MRs attending post-graduate schools of 18 Italian Universities. Each participant was interviewed via an anonymous, self-administered, web-based questionnaire including questions on attitudes regarding influenza vaccination. A total of 2506 MRs were recruited in the survey and 299 (11.9%) of t…

AdultMalemedicine.medical_specialtyPediatricsAttitude of Health PersonnelImmunologySocio-culturaleSettore MED/42 - Igiene Generale E ApplicataInfluenza immunizationmedical residentsPhysiciansHealth careInfluenza Humanmedicineinfluenza vaccination; coverage rateImmunology and AllergyHumansGood practiceCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Adult; Female; Humans; Influenza Vaccines; Influenza Human; Italy; Male; Vaccination; Attitude of Health Personnel; Data Collection; Internship and Residency; Physiciansmulticentre surveyEthical responsibilityPharmacologyCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre surveybusiness.industryinfluenza vaccination; medical residents; multicentre survey; coverage rate; ItalyData CollectionVaccinationInternship and ResidencyItaly coverage rate influenza vaccination medical residents multicentre surveyInfluenzainfluenza vaccinationVaccinationMulticenter studyItalyInfluenza VaccinesVaccination coverageFamily medicineCoverage rate; Influenza vaccination; Italy; Medical residents; Multicentre survey; Immunology and Allergy; Immunology; PharmacologyMulticenter surveyFemalebusinesscoverage rateResearch PaperHuman
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Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise

2010

J Appl Physiol. 2010 Jul;109(1):60-7. Epub 2010 May 6. Hemopoietic and angiogenetic progenitors in healthy athletes: different responses to endurance and maximal exercise. Bonsignore MR, Morici G, Riccioni R, Huertas A, Petrucci E, Veca M, Mariani G, Bonanno A, Chimenti L, Gioia M, Palange P, Testa U. SourceBiomedical Department, Internal and Specialistic Medicine (DIBIMIS), Section of Pneumology, University of Palermo, Via Trabucco, 180, 90146 Palermo, Italy. marisa@ibim.cnr.it Abstract The effects of endurance or maximal exercise on mobilization of bone marrow-derived hemopoietic and angiogenetic progenitors in healthy subjects are poorly defined. In 10 healthy amateur runners, we collect…

AdultMalemedicine.medical_specialtyPhysiologyNeovascularization PhysiologicAntigens CD34Physical exerciseHematopoietic Cell Growth FactorsSettore BIO/09 - FisiologiaRunningangiopoietin; marathon; circulating progenitors; growth factorsAntigens CDEndurance trainingPhysiology (medical)Internal medicinegrowth factorsmedicineHumansAC133 AntigenProgenitor cellGlycoproteinsErythroid Precursor CellsbiologyAthletesbusiness.industryangiopoietinHealthy subjectsEndothelial Cellscirculating progenitorMiddle AgedCadherinsHematopoietic Stem Cellsbiology.organism_classificationHaematopoiesisEndocrinologyAthletesPhysical EnduranceCytokinesAngiogenesis Inducing Agentsadult; angiogenesis inducing agents; angiopoietin; antigens; athletes; blood; cadherins; cd; cd34; circulating progenitors; cytokines; endothelial cells; erythroid precursor cells; glycoproteins; granulocytes; growth factors; hematopoietic cell growth factors; hematopoietic stem cells; humans; male; marathon; middle aged; neovascularization; peptides; physical endurance; physiologic; physiology; runningAC133 antigenMaximal exercisemarathonPeptidesbusinessGranulocytesJournal of Applied Physiology
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