Search results for " III"

I diritti sindacali nel titolo III dello Statuto dei lavoratori

2011

Sommario: 1. I diritti sindacali: struttura del titolo III e differenze rispetto al titolo II dello Statuto dei la­voratori. – 2. I limiti all’esercizio dell’attività sindaca­le privilegiata. – 2.1. segue: la selezione dei soggetti protetti. – 2.2. segue: il criterio dimensionale e la no­zione di unità produttiva. – 2.3. segue: il contempera­mento con interessi pari o sovraordinati. – 3. Il diritto di assemblea tra istanze di democrazia diretta e afflati di democrazia rappresentativa. – 3.1. I soggetti legitti­mati alla convocazione. – 3.2. Il dibattito sulla titolari­tà, individuale o collegiale, del potere di convocazione. – 3.3. L’oggetto dell’assemblea. – 3.4. Il luogo di svol­gimento …

Characteristics of clinical trials in rare vs. common diseases: A register-based Latvian study.

2017

Background Conducting clinical studies in small populations may be very challenging; therefore quality of clinical evidence may differ between rare and non-rare disease therapies. Objective This register-based study aims to evaluate the characteristics of clinical trials in rare diseases conducted in Latvia and compare them with clinical trials in more common conditions. Methods The EU Clinical Trials Register (clinicaltrialsregister.eu) was used to identify interventional clinical trials related to rare diseases (n = 51) and to compose a control group of clinical trials in non-rare diseases (n = 102) for further comparison of the trial characteristics. Results We found no significant diffe…

Legami familiari e configurazioni del Sé

2010

The relationship between credit ratings and asset liquidity: Evidence from Western European banks

2020

This study examines the role of asset liquidity in Western European banks’ credit rating downgrades and upgrades over the 2005–2017 period. The results suggest that changes in bank credit ratings have been more favorable for banks that have a liquid asset portfolio. Furthermore, asset liquidity has a stronger effect on the credit rating of banks that already have an illiquid asset portfolio. In contrast, the effect is significantly smaller or nonexistent for the most liquid banks. These results imply that the new liquidity regulation introduced by the Basel III requirements will improve the stability and hence decrease the fragility of the European banking sector. Furthermore, the benefits …

Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate.

2016

Here we show that inorganic polyphosphate (polyP), a polyanionic metabolic regulator consisting of multiple phosphate residues linked by energy-rich phosphoanhydride bonds, is present in the synovial fluid. In a biomimetic approach, to enhance cartilage synthesis and regeneration, we prepared amorphous polyP microparticles with Mg2+ as counterions. The particles were characterised by X-ray diffraction (XRD), energy-dispersive X-ray (EDX) and Fourier transformed infrared spectroscopic (FTIR) analyses. Similar particles were obtained after addition of Mg2+ ions to a solution containing hyaluronic acid, as a major component of the synovial fluid, and soluble Na-polyP. The viscous paste-like ma…

Banku saistību līmeņa samazināšanās procesa ietekme uz Latvijas tautsaimniecību

2015

2008. gada globālā ekonomiskā krīze vēlreiz apliecināja finanšu sistēmas ciešo saistību ar reālo ekonomiku, tāpēc tiek izstrādāti Basel III banku regulējošie nosacījumi, kuri paredz bankām uzturēt zemāku saistību līmeni, kas savukārt ietekmēs valstu tautsaimniecības. Bakalaura darba mērķis ir analizēt Latvijas komercbanku saistību līmeņa samazināšanās ietekmi uz Latvijas tautsaimniecību, lai raksturotu Basel III regulu iespējamo makroekonomisko ietekmi un izvirzītu priekšlikumus attiecīgajām institūcijām ar nolūku uzlabot makroprudenciālo uzraudzības politiku, kā arī lai izvirzīt priekšlikumus tālākai temata pētniecībai. Banku saistības tiek novērtētas izmantojot Basel III regulējošo nosacī…

Hereditary angioedema type III, angioedema associated with angiotensin II receptor antagonists, and female sex

2004

Janus-faced role of endothelial NO synthase in vascular disease: uncoupling of oxygen reduction from NO synthesis and its pharmacological reversal

2006

Endothelial NO synthase (eNOS) is the predominant enzyme responsible for vascular NO synthesis. A functional eNOS transfers electrons from NADPH to its heme center, where L-arginine is oxidized to L-citrulline and NO. Common conditions predisposing to atherosclerosis, such as hypertension, hypercholesterolemia, diabetes mellitus and smoking, are associated with enhanced production of reactive oxygen species (ROS) and reduced amounts of bioactive NO in the vessel wall. NADPH oxidases represent major sources of ROS in cardiovascular pathophysiology. NADPH oxidase-derived superoxide avidly interacts with eNOS-derived NO to form peroxynitrite (ONOO(-)), which oxidizes the essential NOS cofactor…

Pentaerithrityl tetranitrate improves angiotensin II induced vascular dysfunction via induction of heme oxygenase-1

2010

The organic nitrate pentaerythritol tetranitrate is devoid of nitrate tolerance, which has been attributed to the induction of the antioxidant enzyme heme oxygenase (HO)-1. With the present study, we tested whether chronic treatment with pentaerythritol tetranitrate can improve angiotensin II–induced vascular oxidative stress and dysfunction. In contrast to isosorbide-5 mononitrate (75 mg/kg per day for 7 days), treatment with pentaerythritol tetranitrate (15 mg/kg per day for 7 days) improved the impaired endothelial and smooth muscle function and normalized vascular and cardiac reactive oxygen species production (mitochondria, NADPH oxidase activity, and uncoupled endothelial NO synthase)…

Effects of polymorphisms in endothelial nitric oxide synthase and folate metabolizing genes on the concentration of serum nitrate, folate, and plasma…

2015

Abstract Objectives A number of studies have explored the effects of dietary nitrate on human health. Nitrate in the blood can be recycled to nitric oxide, which is an essential mediator involved in many important biochemical mechanisms. Nitric oxide is also formed in the body from l -arginine by nitric oxide synthase. The aim of this study was to investigate whether genetic polymorphisms in endothelial nitric oxide synthase (eNOS) and genes involved in folate metabolism affect the concentration of serum nitrate, serum folate, and plasma total homocysteine in healthy individuals after folic acid supplementation. Methods In a randomized double-blind, crossover study, participants were given …